Development Level

Tbio 24 | 10,625
Tchem 5 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 2 | 148
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
embryonic lethality prior to t... 1 | 187
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64

Disease

malignant mesothelioma 22 | 3,162
non-small cell lung cancer 22 | 2,798
ovarian cancer 22 | 8,484
medulloblastoma, large-cell 21 | 6,234
psoriasis 20 | 6,685
group 3 medulloblastoma 19 | 2,254
lung cancer 19 | 4,466
adrenocortical carcinoma 18 | 1,427
primitive neuroectodermal tumor 17 | 3,031
glioblastoma 16 | 5,572
osteosarcoma 16 | 7,933
pediatric high grade glioma 14 | 2,712
Breast cancer 12 | 3,094
atypical teratoid / rhabdoid tumor 12 | 4,369
lung adenocarcinoma 12 | 2,713
Cancer 11 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
invasive ductal carcinoma 10 | 2,950
colon cancer 9 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
nasopharyngeal carcinoma 9 | 1,056
posterior fossa group A ependymoma 9 | 1,511
ductal carcinoma in situ 8 | 1,745
Meier-Gorlin syndrome 7 | 12
Endometriosis 6 | 535
Seckel syndrome 6 | 34
Waldenstrons macroglobulinemia 6 | 765
Atopic dermatitis 5 | 944
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Multiple myeloma 5 | 1,327
atypical teratoid/rhabdoid tumor 5 | 1,095
oligodendroglioma 5 | 2,849
sonic hedgehog group medulloblastoma 5 | 1,482
astrocytoma 4 | 1,493
Microcephaly 3 | 149
breast carcinoma 3 | 1,614
pilocytic astrocytoma 3 | 3,086
primary Sjogren syndrome 3 | 789
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Cervix endometriosis 2 | 3
DiGeorge syndrome 2 | 46
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Menopause present (finding) 2 | 20
Metastatic Breast Carcinoma 2 | 21
Pulmonary emphysema 2 | 34
Rothmund-Thomson syndrome 2 | 22
adult high grade glioma 2 | 2,148
dermatomyositis 2 | 933
diabetes mellitus 2 | 1,663
esophageal adenocarcinoma 2 | 737
glioblastoma multiforme 2 | 347
inflammatory breast cancer 2 | 404
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
pancreatic cancer 2 | 2,300
tuberculosis 2 | 1,557
ulcerative colitis 2 | 2,087
Acquired immunodeficiency syndrome 1 | 164
Adenoma 1 | 165
Age related macular degeneration 1 | 84
Ataxia telangiectasia 1 | 31
Bowen-Conradi syndrome 1 | 16
Cerebrovascular disease 1 | 231
Chloracne 1 | 32
Chronic Lymphocytic Leukemia 1 | 242
Colonic Neoplasms 1 | 126
Colorectal Neoplasms 1 | 217
Familial adenomatous polyposis 1 | 31
Gaucher disease type 1 1 | 171
Glaucoma 1 | 134
Gout 1 | 93
IGA Glomerulonephritis 1 | 454
Lactose intolerance 1 | 7
Lynch syndrome 1 | 33
Malaria 1 | 140
Melanoma 1 | 261
Nijmegen breakage syndrome 1 | 23
Nonsyndromic deafness 1 | 121
Peripheral Neuropathy 1 | 303
Pick disease 1 | 1,893
Polycystic Ovary Syndrome 1 | 332
Premature ovarian failure 1 | 64
Seborrheic keratosis 1 | 6
Syphilis 1 | 18
Typhoid fever 1 | 22
Velocardiofacial syndrome 1 | 45
Xeroderma pigmentosum 1 | 41
active Crohn's disease 1 | 918
acute myeloid leukemia 1 | 780
cystic fibrosis 1 | 1,665
medulloblastoma 1 | 1,524
pancreatic carcinoma 1 | 567
pituitary cancer 1 | 1,972
substance-related disorder 1 | 105
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 32 | 17,995
Cardiovascular System 32 | 17,958
Digestive Tract 32 | 18,473
Endocrine System 32 | 18,512
Female tissues 32 | 18,647
Liver and Pancreas 32 | 18,136
Male tissues 32 | 17,969
Nervous System 32 | 18,561
Respiratory system 32 | 17,484
Skin and soft tissues 32 | 18,115
Urinary Tract 32 | 18,444

Target Family

Non-IDG 21 | 11,971
Enzyme 9 | 4,146
Kinase 2 | 634

Reactome Pathway

Activation of the pre-replicat... 32 | 32
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76
DNA primase small subunit PRIM1 Tbio Enzyme -0.88906 8.05 121
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.49781 32.5 130
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50789 31.4 61
DNA replication licensing factor MCM3 MCM3 Tbio Non-IDG -2.00856 94.2 378
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.35509 26.1 158
DNA helicase MCM8 MCM8 Tbio Enzyme -1.35641 25.2 159
Cell division control protein 6 homolog CDC6 Tchem Non-IDG -2.48727 321.6 473