Development Level

Tbio 26 | 11,651
Tchem 3 | 1,388
Tclin 2 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 2 | 220
increased mean corpuscular vol... 2 | 92
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic growth retardation 1 | 106
increased grip strength 1 | 41
increased heart weight 1 | 62
prenatal lethality prior to he... 1 | 87

Disease

group 3 medulloblastoma 24 | 4,104
malignant mesothelioma 22 | 3,232
non-small cell lung cancer 22 | 2,890
ovarian cancer 21 | 8,520
Carcinoma 20 | 11,493
medulloblastoma, large-cell 20 | 6,241
lung cancer 19 | 4,740
psoriasis 19 | 6,694
adrenocortical carcinoma 18 | 1,428
glioblastoma 17 | 5,792
primitive neuroectodermal tumor 16 | 3,035
atypical teratoid / rhabdoid tumor 15 | 5,112
osteosarcoma 15 | 7,950
Breast cancer 13 | 3,578
Cancer 12 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
nasopharyngeal carcinoma 10 | 1,058
adult high grade glioma 9 | 3,801
colon cancer 9 | 1,478
invasive ductal carcinoma 9 | 2,951
Autosomal recessive predisposition 7 | 1,442
Meier-Gorlin syndrome 7 | 10
Waldenstrons macroglobulinemia 7 | 765
ductal carcinoma in situ 7 | 1,745
ependymoma 7 | 4,679
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 7
Endometriosis 6 | 540
Seckel syndrome 6 | 34
oligodendroglioma 6 | 2,850
pediatric high grade glioma 6 | 1,064
Atopic dermatitis 5 | 952
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Isolated growth hormone deficiency 5 | 30
Multiple myeloma 5 | 1,332
Small head 5 | 374
astrocytoma 5 | 1,146
Birth length less than 3rd percentile 4 | 6
Congenital small ears 4 | 48
Cryptorchidism 4 | 296
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
Pediatric failure to thrive 4 | 365
Slender, gracile long tubular bones 4 | 21
primary Sjogren syndrome 4 | 735
Astrocytoma, Pilocytic 3 | 3,081
Congenital hypoplasia of breast 3 | 25
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Feeding difficulties 3 | 127
Gastroesophageal reflux disease 3 | 110
Heartburn 3 | 78
Hypertrophy of clitoris 3 | 40
Hypoplasia of the maxilla 3 | 66
Hypoplastic mandible condyle 3 | 275
Hypotrophic maxilla 3 | 66
Kidney cancer 3 | 2,613
Mandibular hypoplasia 3 | 275
Maxillary retrognathia 3 | 66
Microcephaly 3 | 166
Micrognathism 3 | 275
Microstomia 3 | 78
Retrusion of upper jaw bones 3 | 66
breast carcinoma 3 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
Abnormality of metabolism/homeostasis 2 | 134
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 30
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Deafness 2 | 198
Dull intelligence 2 | 645
Genu varum 2 | 29
Hearing Loss, Partial 2 | 185
Infectious disease of lung 2 | 29
Malignant tumor of ovary 2 | 25
Mental and motor retardation 2 | 608
Metastatic Breast Carcinoma 2 | 21
Multiple pulmonary infections 2 | 29
Patella aplasia-hypoplasia 2 | 12
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Pulmonary emphysema 2 | 48
Recurrent pneumonia 2 | 29
Recurrent pulmonary infections 2 | 29
Recurrent respiratory infections 2 | 141
Short ribs 2 | 30
Triangular face 2 | 58
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
hearing impairment 2 | 199
interstitial cystitis 2 | 2,312
posterior fossa group A ependymoma 2 | 468
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 9 | 4,145
Kinase 2 | 634

Reactome Pathway

Activation of the pre-replicat... 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
DNA replication licensing factor MCM3 MCM3 Tbio Non-IDG -2.04750 101.5 390
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.44266 2522.8 1114
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.22644 169.3 112
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138