Development Level

Tchem 21 | 1,598
Tbio 18 | 11,445
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 4 | 220
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal forebrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hydrometra 2 | 53
increased bone mineral density 2 | 72
microphthalmia 2 | 26
preweaning lethality, incomple... 2 | 499
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased neutrophil cell numb... 1 | 42
enlarged heart 1 | 210
enlarged uterus 1 | 11
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small epididymis 1 | 3
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 33 | 11,493
osteosarcoma 33 | 7,950
ovarian cancer 32 | 8,520
psoriasis 28 | 6,694
medulloblastoma, large-cell 25 | 6,241
malignant mesothelioma 22 | 3,232
glioblastoma 19 | 5,792
atypical teratoid / rhabdoid tumor 17 | 5,112
Pick disease 16 | 1,894
Cancer 15 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Breast cancer 14 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung cancer 13 | 4,740
ductal carcinoma in situ 12 | 1,745
group 3 medulloblastoma 12 | 4,104
invasive ductal carcinoma 12 | 2,951
adult high grade glioma 11 | 3,801
Obesity 10 | 678
interstitial cystitis 10 | 2,312
Carcinoma, Hepatocellular 9 | 228
Liver carcinoma 9 | 240
active Crohn's disease 9 | 922
acute quadriplegic myopathy 9 | 1,158
astrocytic glioma 9 | 2,597
oligodendroglioma 9 | 2,850
pituitary cancer 9 | 1,972
Kidney cancer 8 | 2,613
astrocytoma 8 | 1,146
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
group 4 medulloblastoma 8 | 1,855
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Fatty liver disease 7 | 103
aldosterone-producing adenoma 7 | 665
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Atherosclerosis 6 | 291
Intellectual disability 6 | 1,016
Lipid metabolism disorder 6 | 114
Schizophrenia 6 | 1,160
non primary Sjogren syndrome sicca 6 | 891
Breast Neoplasms 5 | 445
Cataract 5 | 297
Kidney Failure, Chronic 5 | 46
Mammary Neoplasms 5 | 425
Multiple myeloma 5 | 1,332
Prostatic Neoplasms 5 | 495
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
gastric cancer 5 | 459
pediatric high grade glioma 5 | 1,064
Astrocytoma, Pilocytic 4 | 3,081
Autistic Disorder 4 | 364
Autosomal recessive predisposition 4 | 1,442
Chemical and Drug Induced Liver Injury 4 | 195
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Hepatomegaly 4 | 285
Insulin Resistance 4 | 72
Lens Opacities 4 | 231
Muscle hypotonia 4 | 571
Pediatric failure to thrive 4 | 365
Porokeratosis of Mibelli 4 | 4
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Small head 4 | 374
Waldenstrons macroglobulinemia 4 | 765
colon cancer 4 | 1,478
hepatocellular carcinoma 4 | 547
lung carcinoma 4 | 2,843
Blepharoptosis 3 | 231
Chronic Lymphocytic Leukemia 3 | 262
Cognitive delay 3 | 608
Congenital Epicanthus 3 | 177
Congenital deafness 3 | 185
Deafness 3 | 198
Dull intelligence 3 | 645
Endometriosis 3 | 540
Hearing Loss, Partial 3 | 185
Hypoplastic mandible condyle 3 | 275
Liver Cirrhosis, Experimental 3 | 769
Melanoma 3 | 711
Mental and motor retardation 3 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 45 | 16,909
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Nervous System 45 | 16,725
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678

Target Family

Enzyme 21 | 4,145
Non-IDG 7 | 12,091
Transcription Factor 7 | 1,400
Nuclear Receptor 5 | 48
Epigenetic 4 | 242
Kinase 1 | 634

Reactome Pathway

Activation of gene expression ... 45 | 45
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30
Trimethylguanosine synthase TGS1 Tbio Enzyme -1.40283 26.5 103
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155