Development Level

Tbio 56 | 10,625
Tdark 13 | 7,003
Tchem 12 | 1,890
Tclin 5 | 602

IMPC Term

preweaning lethality, incomple... 3 | 260
abnormal retinal pigmentation 2 | 61
abnormal tooth morphology 2 | 24
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal digit morphology 1 | 13
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal social/conspecific in... 1 | 3
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased B cell number 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
small spleen 1 | 11
small testis 1 | 37

Disease

ovarian cancer 48 | 8,484
osteosarcoma 37 | 7,933
psoriasis 34 | 6,685
Cancer 27 | 2,346
glioblastoma 27 | 5,572
Breast cancer 25 | 3,094
lung cancer 25 | 4,466
atypical teratoid / rhabdoid tumor 21 | 4,369
malignant mesothelioma 20 | 3,162
medulloblastoma, large-cell 18 | 6,234
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
lung adenocarcinoma 15 | 2,713
Multiple myeloma 14 | 1,327
breast carcinoma 14 | 1,614
invasive ductal carcinoma 14 | 2,950
pancreatic cancer 14 | 2,300
posterior fossa group A ependymoma 13 | 1,511
Mammary Neoplasms 12 | 410
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
non-small cell lung cancer 12 | 2,798
cystic fibrosis 11 | 1,665
Carcinoma 10 | 2,147
astrocytoma 10 | 1,493
ductal carcinoma in situ 10 | 1,745
group 3 medulloblastoma 10 | 2,254
primitive neuroectodermal tumor 10 | 3,031
interstitial cystitis 9 | 2,299
lung carcinoma 9 | 2,844
pituitary cancer 9 | 1,972
Intellectual disability 8 | 573
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 780
adult high grade glioma 8 | 2,148
pilocytic astrocytoma 8 | 3,086
subependymal giant cell astrocytoma 8 | 2,287
Cleft palate 7 | 125
Squamous cell carcinoma of esophagus 7 | 82
colon cancer 7 | 1,475
diabetes mellitus 7 | 1,663
non-small cell lung carcinoma 7 | 413
oligodendroglioma 7 | 2,849
primary pancreatic ductal adenocarcinoma 7 | 1,271
spina bifida 7 | 1,064
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,427
astrocytic glioma 6 | 2,241
cutaneous lupus erythematosus 6 | 1,056
pediatric high grade glioma 6 | 2,712
Bladder Neoplasm 5 | 109
Carcinoma, Transitional Cell 5 | 31
Endometriosis 5 | 535
Esophageal atresia 5 | 25
Kabuki syndrome 5 | 27
Leukemia 5 | 88
Obesity 5 | 616
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Stomach Neoplasms 5 | 282
acute quadriplegic myopathy 5 | 1,157
ependymoma 5 | 2,514
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
sonic hedgehog group medulloblastoma 5 | 1,482
ulcerative colitis 5 | 2,087
Adenoid Cystic Carcinoma 4 | 99
Autistic Disorder 4 | 320
Craniofacial Abnormalities 4 | 147
Kaposi's Sarcoma Skin Lesions 4 | 7
Kidney cancer 4 | 118
Melanoma 4 | 261
VACTERL association 4 | 23
dermatomyositis 4 | 933
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Acne vulgaris 3 | 16
Adenocarcinoma 3 | 115
Alzheimer's disease 3 | 644
Chronic Lymphocytic Leukemia 3 | 242
Cleft Lip 3 | 91
Connective tissue disease 3 | 59
Down syndrome 3 | 548
Endometrial Neoplasms 3 | 50
Hypospadias 3 | 65
Immune system cancer 3 | 38
Leishmaniasis 3 | 49
Liver carcinoma 3 | 217
Lupus erythematosus 3 | 80
Lymphoid leukemia 3 | 69
Lymphoma, Follicular 3 | 20
Microphthalmia 3 | 78
Primary cutaneous T-cell lymphoma 3 | 24
Sezary Syndrome 3 | 26
atypical teratoid/rhabdoid tumor 3 | 1,095
inflammatory breast cancer 3 | 404
medulloblastoma 3 | 1,524
primary Sjogren syndrome 3 | 789

Tissue

Female tissues 86 | 18,647
Male tissues 86 | 17,969
Blood and immune system 85 | 17,995
Digestive Tract 85 | 18,473
Liver and Pancreas 84 | 18,136
Nervous System 84 | 18,561
Endocrine System 83 | 18,512
Urinary Tract 83 | 18,444
Cardiovascular System 82 | 17,958
Respiratory system 81 | 17,484
Skin and soft tissues 76 | 18,115

Target Family

Non-IDG 37 | 11,971
Transcription Factor 24 | 1,400
Enzyme 13 | 4,146
Epigenetic 8 | 242
Nuclear Receptor 4 | 48

Reactome Pathway

Activation of anterior HOX gen... 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein Hox-B3 HOXB3 Tbio Transcription Factor -1.60816 41.2 104
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Lysine-specific demethylase 6A KDM6A Tchem Epigenetic -2.14014 144.5 92
Homeobox protein Hox-C4 HOXC4 Tbio Transcription Factor -1.35128 25.1 167
Homeobox protein Hox-D4 HOXD4 Tbio Transcription Factor -1.67262 45.7 100
Retinoic acid receptor gamma RARG Tclin Nuclear Receptor -2.08257 117.2 123
Homeobox protein Hox-A1 HOXA1 Tbio Transcription Factor -1.95847 92.9 260
PAX-interacting protein 1 PAXIP1 Tbio Non-IDG -1.59834 42.1 69
Polycomb group RING finger protein 2 PCGF2 Tbio Non-IDG -1.55007 40.7 161