Development Level

Tbio 56 | 10,625
Tdark 13 | 7,003
Tchem 12 | 1,890
Tclin 5 | 602

IMPC Phenotype

preweaning lethality, incomple... 3 | 260
abnormal retinal pigmentation 2 | 61
abnormal tooth morphology 2 | 24
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal digit morphology 1 | 13
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal social-conspecific in... 1 | 3
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased B cell number 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
small spleen 1 | 11
small testis 1 | 37

Disease

ovarian cancer 48 | 8,491
osteosarcoma 37 | 7,933
psoriasis 34 | 6,685
Cancer 27 | 2,346
glioblastoma 27 | 5,572
Breast cancer 25 | 3,098
lung cancer 25 | 4,473
atypical teratoid / rhabdoid tumor 21 | 4,369
malignant mesothelioma 20 | 3,163
medulloblastoma, large-cell 18 | 6,234
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
lung adenocarcinoma 15 | 2,714
Multiple myeloma 14 | 1,327
breast carcinoma 14 | 1,614
invasive ductal carcinoma 14 | 2,950
pancreatic cancer 14 | 2,300
posterior fossa group A ependymoma 13 | 1,511
Mammary Neoplasms 12 | 410
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
non-small cell lung cancer 12 | 2,798
cystic fibrosis 11 | 1,670
Carcinoma 10 | 2,147
astrocytoma 10 | 1,493
ductal carcinoma in situ 10 | 1,745
group 3 medulloblastoma 10 | 2,254
primitive neuroectodermal tumor 10 | 3,031
interstitial cystitis 9 | 2,299
lung carcinoma 9 | 2,844
pituitary cancer 9 | 1,972
Intellectual disability 8 | 573
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 785
adult high grade glioma 8 | 2,148
pilocytic astrocytoma 8 | 3,086
subependymal giant cell astrocytoma 8 | 2,287
Cleft palate 7 | 125
Squamous cell carcinoma of esophagus 7 | 82
colon cancer 7 | 1,475
diabetes mellitus 7 | 1,663
non-small cell lung carcinoma 7 | 413
oligodendroglioma 7 | 2,849
primary pancreatic ductal adenocarcinoma 7 | 1,271
spina bifida 7 | 1,064
Waldenstrons macroglobulinemia 6 | 764
adrenocortical carcinoma 6 | 1,427
astrocytic glioma 6 | 2,241
cutaneous lupus erythematosus 6 | 1,056
pediatric high grade glioma 6 | 2,712
Bladder Neoplasm 5 | 109
Carcinoma, Transitional Cell 5 | 31
Endometriosis 5 | 535
Esophageal atresia 5 | 25
Kabuki syndrome 5 | 29
Leukemia 5 | 88
Obesity 5 | 616
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,170
Stomach Neoplasms 5 | 282
acute quadriplegic myopathy 5 | 1,157
ependymoma 5 | 2,514
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
sonic hedgehog group medulloblastoma 5 | 1,482
ulcerative colitis 5 | 2,087
Adenoid Cystic Carcinoma 4 | 99
Autistic Disorder 4 | 320
Craniofacial Abnormalities 4 | 147
Kaposi's Sarcoma Skin Lesions 4 | 7
Kidney cancer 4 | 121
Melanoma 4 | 261
VACTERL association 4 | 23
dermatomyositis 4 | 966
gastric cancer 4 | 436
hepatocellular carcinoma 4 | 550
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Acne vulgaris 3 | 16
Adenocarcinoma 3 | 115
Alzheimer's disease 3 | 644
Cleft Lip 3 | 91
Connective tissue disease 3 | 59
Down syndrome 3 | 548
Endometrial Neoplasms 3 | 50
Hypospadias 3 | 65
Immune system cancer 3 | 38
Leishmaniasis 3 | 49
Liver carcinoma 3 | 217
Lupus erythematosus 3 | 80
Lymphoid leukemia 3 | 69
Lymphoma, Follicular 3 | 20
Microphthalmia 3 | 79
Primary cutaneous T-cell lymphoma 3 | 29
Sezary Syndrome 3 | 26
atypical teratoid/rhabdoid tumor 3 | 1,095
chronic lymphocytic leukemia 3 | 244
inflammatory breast cancer 3 | 404
medulloblastoma 3 | 1,524
primary Sjogren syndrome 3 | 788

Tissue

Female tissues 86 | 18,646
Male tissues 86 | 17,968
Blood and immune system 85 | 17,994
Digestive Tract 85 | 18,472
Liver and Pancreas 84 | 18,135
Nervous System 84 | 18,560
Endocrine System 83 | 18,511
Urinary Tract 83 | 18,443
Cardiovascular System 82 | 17,957
Respiratory system 81 | 17,483
Skin and soft tissues 76 | 18,114

Target Family

Non-IDG 37 | 11,969
Transcription Factor 24 | 1,400
Enzyme 13 | 4,146
Epigenetic 8 | 242
Nuclear Receptor 4 | 48

Reactome Pathway

Activation of anterior HOX gen... 86 | 86
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
CCR4-NOT transcription complex subunit 6 CNOT6 Tchem Non-IDG -1.22516 17.4 101
Homeobox protein Hox-A2 HOXA2 Tbio Transcription Factor -2.28221 194.5 72
Homeobox protein Hox-A3 HOXA3 Tbio Transcription Factor -1.62995 43.1 146
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159