Development Level

Tchem 16 | 1,598
Tclin 11 | 613
Tbio 10 | 11,445

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

abnormal behavior 3 | 298
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
preweaning lethality, complete... 3 | 979
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating calcium ... 1 | 36
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart weight 1 | 27
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
tremors 1 | 39

Disease

Carcinoma 31 | 11,493
medulloblastoma, large-cell 29 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
glioblastoma 27 | 5,792
ependymoma 25 | 4,679
adult high grade glioma 23 | 3,801
primitive neuroectodermal tumor 22 | 3,035
osteosarcoma 21 | 7,950
group 3 medulloblastoma 20 | 4,104
Astrocytoma, Pilocytic 19 | 3,081
astrocytic glioma 19 | 2,597
oligodendroglioma 19 | 2,850
ovarian cancer 19 | 8,520
Bipolar Disorder 15 | 666
Kidney cancer 15 | 2,613
Pick disease 15 | 1,894
Schizophrenia 15 | 1,160
psoriasis 14 | 6,694
Epilepsy 13 | 792
lung carcinoma 13 | 2,843
lung cancer 11 | 4,740
subependymal giant cell astrocytoma 11 | 2,287
Cancer 10 | 2,499
Intellectual disability 10 | 1,016
Depressive disorder 9 | 409
General anesthesia 9 | 53
Local anesthesia 9 | 40
Major Depressive Disorder 9 | 301
Toxic encephalopathy 9 | 141
malignant mesothelioma 9 | 3,232
Breast cancer 8 | 3,578
Cocaine-Related Disorders 8 | 92
Melanoma 8 | 711
Mental Depression 8 | 333
Parkinson's disease 8 | 392
group 4 medulloblastoma 8 | 1,855
pancreatic cancer 8 | 2,398
Alcoholic Intoxication, Chronic 7 | 289
Alzheimer's disease 7 | 658
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Short stature 7 | 531
Skin cancer 7 | 469
Substance Withdrawal Syndrome 7 | 55
tuberculosis 7 | 2,010
Amyotrophic lateral sclerosis 6 | 451
Lennox-Gastaut syndrome 6 | 34
Simple partial seizure 6 | 26
Unipolar Depression 6 | 250
pituitary cancer 6 | 1,972
Alcoholism 5 | 45
Arteriosclerotic Parkinsonism 5 | 8
Autistic Disorder 5 | 364
Cognitive delay 5 | 608
Extrapyramidal disease 5 | 8
Global developmental delay 5 | 608
Hyperalgesia 5 | 83
Influenza A Prevention 5 | 7
Influenza due to Influenza A virus 5 | 7
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Mood Disorders 5 | 184
Muscle hypotonia 5 | 571
Parkinsonism 5 | 18
Postencephalitic parkinsonism 5 | 12
Seizures 5 | 596
Vascular disease 5 | 319
colon cancer 5 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
Autosomal recessive predisposition 4 | 1,442
Byzanthine arch palate 4 | 194
Cerebrovascular disease 4 | 238
Coffin-Lowry syndrome 4 | 9
Concave bridge of nose 4 | 195
Congenital Epicanthus 4 | 177
Congenital pectus carinatum 4 | 52
Delayed bone age 4 | 136
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Downward slant of palpebral fissure 4 | 158
Epilepsy characterized by intractable complex partial seizures 4 | 28
Full lower lip 4 | 64
Huntington's disease 4 | 76
Hyperactive behavior 4 | 91
Hyperkinesis 4 | 32
Joint hyperflexibility 4 | 78
Lung Neoplasms 4 | 232
Migraine Prevention 4 | 23
Noonan syndrome 4 | 34
Orbital separation excessive 4 | 244
Partial seizure 4 | 15
Prominent lower lip 4 | 64
Tonic-clonic epilepsy 4 | 47
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 37 | 18,159
Digestive Tract 36 | 17,369
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Blood and immune system 35 | 16,909
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Respiratory system 34 | 16,393
Urinary Tract 34 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Kinase 17 | 634
Ion Channel 9 | 344
Enzyme 6 | 4,145
Non-IDG 4 | 12,091
Transcription Factor 1 | 1,400

Reactome Pathway

Activation of NMDA receptor an... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.61657 45.3 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Ras-specific guanine nucleotide-releasing factor 2 RASGRF2 Tbio Non-IDG -1.31521 23.7 21
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158