Development Level

Tbio 49 | 11,651
Tchem 10 | 1,388
Tclin 5 | 612
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
tremors 1 | 39

Disease

ovarian cancer 47 | 8,520
Carcinoma 31 | 11,493
lung cancer 30 | 4,740
Multiple myeloma 29 | 1,332
psoriasis 28 | 6,694
glioblastoma 26 | 5,792
osteosarcoma 25 | 7,950
Cancer 17 | 2,499
HIV Infections 15 | 102
dermatomyositis 13 | 966
atypical teratoid / rhabdoid tumor 12 | 5,112
Waldenstrons macroglobulinemia 11 | 765
ependymoma 11 | 4,679
medulloblastoma, large-cell 11 | 6,241
Breast cancer 10 | 3,578
astrocytoma 9 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
non-small cell lung cancer 9 | 2,890
oligodendroglioma 9 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
subependymal giant cell astrocytoma 9 | 2,287
Liver Cirrhosis, Experimental 8 | 769
adult high grade glioma 8 | 3,801
group 3 medulloblastoma 8 | 4,104
malignant mesothelioma 8 | 3,232
Kidney cancer 7 | 2,613
Mantle cell lymphoma 7 | 23
Pick disease 7 | 1,894
diabetes mellitus 7 | 1,728
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
non primary Sjogren syndrome sicca 6 | 891
Rheumatoid arthritis 5 | 1,191
acute myeloid leukemia 5 | 783
astrocytic glioma 5 | 2,597
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
primary pancreatic ductal adenocarcinoma 5 | 1,109
Anemia 4 | 365
Autosomal recessive predisposition 4 | 1,442
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Immunologic Deficiency Syndromes 4 | 113
Osteoporosis 4 | 363
colon cancer 4 | 1,478
esophageal adenocarcinoma 4 | 737
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819
Attention deficit hyperactivity disorder 3 | 278
Brain Ischemia 3 | 110
Crohn's disease 3 | 321
Flexion contracture of proximal interphalangeal joint 3 | 75
Heat Stroke 3 | 13
Hyperhidrosis disorder 3 | 81
Increased sweating 3 | 81
Liver cancer 3 | 604
Sweating 3 | 81
acute quadriplegic myopathy 3 | 1,158
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Colonic Neoplasms 2 | 142
Curvature of spine 2 | 282
Elevated hepatic transaminases 2 | 81
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Frontal bossing 2 | 157
Hepatic enzyme increased 2 | 81
Hypertension 2 | 396
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Pneumonia 2 | 174
Seizures 2 | 596
Sparse hair 2 | 59
Subclinical abnormal liver function tests 2 | 81
Thin, sparse hair 2 | 59
Transaminases increased 2 | 81
Unipolar Depression 2 | 250
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
medulloblastoma 2 | 720

Tissue

Endocrine System 66 | 18,159
Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678
Cardiovascular System 64 | 15,192
Liver and Pancreas 64 | 16,750
Skin and soft tissues 64 | 17,230

Target Family

Enzyme 41 | 4,145
Non-IDG 18 | 12,091
Kinase 5 | 634
Transcription Factor 3 | 1,400

Reactome Pathway

Activation of NF-kappaB in B c... 67 | 67
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305