Development Level

Tbio 38 | 11,178
Tchem 23 | 1,885
Tclin 5 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
tremors 1 | 39

Disease

ovarian cancer 31 | 8,297
Carcinoma 26 | 11,192
lung cancer 21 | 4,607
osteosarcoma 19 | 7,766
glioblastoma 18 | 5,635
Multiple myeloma 16 | 1,296
psoriasis 16 | 6,514
Cancer 13 | 2,388
HIV Infections 10 | 94
atypical teratoid / rhabdoid tumor 9 | 4,971
dermatomyositis 8 | 941
medulloblastoma, large-cell 8 | 6,086
non-small cell lung cancer 8 | 2,799
Kidney cancer 7 | 2,548
astrocytoma 7 | 1,113
lung adenocarcinoma 7 | 2,627
Breast cancer 6 | 3,469
ependymoma 6 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
subependymal giant cell astrocytoma 6 | 2,230
Liver Cirrhosis, Experimental 5 | 733
Pick disease 5 | 1,856
adult high grade glioma 5 | 3,701
group 4 medulloblastoma 5 | 1,806
malignant mesothelioma 5 | 3,135
oligodendroglioma 5 | 2,768
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,911
tuberculosis 5 | 1,963
Diabetes Mellitus, Non-Insulin-Dependent 4 | 140
Diabetes Mellitus, Type 2 4 | 136
Rheumatoid arthritis 4 | 1,156
acute myeloid leukemia 4 | 760
group 3 medulloblastoma 4 | 4,002
invasive ductal carcinoma 4 | 2,867
lung carcinoma 4 | 2,755
primary pancreatic ductal adenocarcinoma 4 | 1,071
progressive supranuclear palsy 4 | 656
ulcerative colitis 4 | 1,765
Astrocytoma, Pilocytic 3 | 3,006
Attention deficit hyperactivity disorder 3 | 272
Brain Ischemia 3 | 107
Heat Stroke 3 | 12
Immunologic Deficiency Syndromes 3 | 110
Liver cancer 3 | 589
Waldenstrons macroglobulinemia 3 | 742
acute quadriplegic myopathy 3 | 1,133
astrocytic glioma 3 | 2,530
colon cancer 3 | 1,428
diabetes mellitus 3 | 1,683
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,902
pancreatic cancer 3 | 2,322
Acquired scoliosis 2 | 274
Adult T-Cell Lymphoma/Leukemia 2 | 29
Agammaglobulinemia 2 | 34
Anemia 2 | 353
Arthritis 2 | 276
Arthritis, Rheumatoid 2 | 169
Atopic dermatitis 2 | 915
Breast Neoplasms 2 | 423
Carcinoma, Renal Cell 2 | 121
Cholestasis, Extrahepatic 2 | 20
Colonic Neoplasms 2 | 133
Crohn's disease 2 | 311
Curvature of spine 2 | 275
Dental abnormalities 2 | 57
Ectodermal dysplasia, hypohidrotic, with immune deficiency 2 | 2
Epilepsy 2 | 775
Esophageal Squamous Cell Carcinoma 2 | 72
Flexion contracture of proximal interphalangeal joint 2 | 74
Frontal bossing 2 | 154
Hyperglycemia 2 | 134
Hypertension 2 | 372
Hypodontia 2 | 81
Hypohidrotic ectodermal dysplasia with immunodeficiency 2 | 2
Infantile onset 2 | 236
Inflammatory bowel disease 2 | 148
Leukemia-Lymphoma, Adult T-Cell 2 | 29
Mammary Neoplasms 2 | 403
Melanoma 2 | 689
Neoplastic Cell Transformation 2 | 83
Osteoporosis 2 | 348
Parkinson's disease 2 | 378
Pick's disease 2 | 15
Pneumonia 2 | 169
Renal Cell Carcinoma 2 | 211
Schizophrenia 2 | 1,136
Seizures 2 | 584
Sparse hair 2 | 59
Squamous cell carcinoma of esophagus 2 | 72
Stevens-Johnson syndrome 2 | 92
Syndactyly of fingers 2 | 48
Thin, sparse hair 2 | 59
Tooth Abnormalities 2 | 66
esophageal adenocarcinoma 2 | 696
interstitial cystitis 2 | 2,237
juvenile dermatomyositis 2 | 1,147
medulloblastoma 2 | 702
primitive neuroectodermal tumor 2 | 2,957
sarcoidosis 2 | 357

Tissue

Endocrine System 66 | 18,159
Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678
Cardiovascular System 64 | 15,192
Liver and Pancreas 64 | 16,750
Skin and soft tissues 64 | 17,230

Target Family

Enzyme 41 | 4,145
Non-IDG 18 | 12,091
Kinase 5 | 634
Transcription Factor 3 | 1,400

Reactome Pathway

Activation of NF-kappaB in B c... 67 | 67
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome subunit beta type-11 PSMB11 Tchem Enzyme -1.40386 27.2 74
26S proteasome non-ATPase regulatory subunit 2 PSMD2 Tbio Enzyme -1.60281 36.3 389
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Proteasome subunit beta type-8 PSMB8 Tclin Enzyme -2.43601 278.6 295
Proteasome subunit beta type-6 PSMB6 Tbio Enzyme -1.08909 10.9 98
26S proteasome non-ATPase regulatory subunit 1 PSMD1 Tchem Enzyme -1.36924 21.2 105
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235