Development Level

Tbio 37 | 10,625
Tchem 23 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 3 | 633
decreased lean body mass 2 | 195
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal skin condition 1 | 6
absent vibrissae 1 | 14
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating amylase ... 1 | 24
decreased circulating sodium l... 1 | 18
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased thermal nociceptive ... 1 | 9
tremors 1 | 34

Disease

ovarian cancer 47 | 8,484
lung cancer 30 | 4,466
Multiple myeloma 29 | 1,327
psoriasis 28 | 6,685
glioblastoma 25 | 5,572
osteosarcoma 25 | 7,933
Cancer 17 | 2,346
HIV Infections 15 | 100
dermatomyositis 14 | 933
atypical teratoid / rhabdoid tumor 12 | 4,369
Waldenstrons macroglobulinemia 11 | 765
medulloblastoma, large-cell 11 | 6,234
astrocytoma 10 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
oligodendroglioma 10 | 2,849
Breast cancer 9 | 3,094
diabetes mellitus 8 | 1,663
ependymoma 8 | 2,514
malignant mesothelioma 8 | 3,162
non-small cell lung cancer 8 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
subependymal giant cell astrocytoma 8 | 2,287
Mantle cell lymphoma 7 | 18
Pick disease 7 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
lung adenocarcinoma 7 | 2,713
lung carcinoma 7 | 2,844
pediatric high grade glioma 7 | 2,712
primary pancreatic ductal adenocarcinoma 7 | 1,271
ulcerative colitis 7 | 2,087
invasive ductal carcinoma 6 | 2,950
non primary Sjogren syndrome sicca 6 | 840
pancreatic cancer 6 | 2,300
pilocytic astrocytoma 6 | 3,086
tuberculosis 6 | 1,557
Rheumatoid Arthritis 5 | 1,160
acute myeloid leukemia 5 | 780
astrocytic glioma 5 | 2,241
group 3 medulloblastoma 5 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
medulloblastoma 5 | 1,524
primary Sjogren syndrome 5 | 789
Carcinoma 4 | 2,147
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
IGA Glomerulonephritis 4 | 454
colon cancer 4 | 1,475
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,875
interstitial cystitis 4 | 2,299
juvenile dermatomyositis 4 | 1,189
posterior fossa group A ependymoma 4 | 1,511
primitive neuroectodermal tumor 4 | 3,031
progressive supranuclear palsy 4 | 674
Brain Ischemia 3 | 87
Crohn's disease 3 | 304
Heat Stroke 3 | 12
Lymphoma 3 | 56
acute quadriplegic myopathy 3 | 1,157
Adult T-Cell Lymphoma/Leukemia 2 | 30
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
Arthritis 2 | 248
Autistic Disorder 2 | 320
Cleft palate 2 | 125
Colonic Neoplasms 2 | 126
Diffuse large B-cell lymphoma 2 | 41
Edwards syndrome 2 | 15
Histoplasmosis 2 | 22
Hodgkin Disease 2 | 16
Inflammatory bowel disease 2 | 142
Kidney Failure, Chronic 2 | 45
Mammary Neoplasms 2 | 410
Mammary Neoplasms, Experimental 2 | 150
Myocardial Ischemia 2 | 169
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Neoplastic Cell Transformation 2 | 81
Obesity 2 | 616
Osteoporosis 2 | 257
Parkinson's disease 2 | 364
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Renal Cell Carcinoma 2 | 199
Sezary Syndrome 2 | 26
Squamous cell carcinoma of esophagus 2 | 82
Stevens-Johnson syndrome 2 | 78
active Crohn's disease 2 | 918
adult high grade glioma 2 | 2,148
chronic kidney disease 2 | 90
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis 2 | 1,665
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 532
sarcoidosis 2 | 358
tuberculosis and treatment for 6 months 2 | 686
Limb Deformities, Congenital 1 | 16
Malignant neoplasm of testis 1 | 5
Osteopetrosis 1 | 40
Tooth agenesis 1 | 36
hand, foot and mouth disease 1 | 11

Tissue

Blood and immune system 66 | 17,995
Digestive Tract 66 | 18,473
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Nervous System 66 | 18,561
Urinary Tract 66 | 18,444
Cardiovascular System 65 | 17,958
Respiratory system 65 | 17,484
Skin and soft tissues 64 | 18,115

Target Family

Enzyme 41 | 4,146
Non-IDG 17 | 11,971
Kinase 5 | 634
Transcription Factor 3 | 1,400

Reactome Pathway

Activation of NF-kappaB in B c... 66 | 66
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.83653 71.4 158
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.69461 4.24 679
NF-kappa-B essential modulator IKBKG Tchem Kinase -3.03588 1121.7 849
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.35199 201.1 1028
26S protease regulatory subunit 8 PSMC5 Tbio Enzyme -1.68576 49.6 167