Development Level

Tchem 21 | 1,598
Tbio 6 | 11,445
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal skin coloration 2 | 25
increased bone mineral content 2 | 108
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal esophagus morphology 1 | 5
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vibrissa morphology 1 | 25
absent lymph nodes 1 | 3
anophthalmia 1 | 33
athymia 1 | 2
brachydactyly 1 | 19
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
increased vertical activity 1 | 24
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 22 | 11,493
Cancer 20 | 2,499
osteosarcoma 16 | 7,950
cystic fibrosis 14 | 1,696
ovarian cancer 13 | 8,520
psoriasis 13 | 6,694
Arthritis 12 | 290
lung adenocarcinoma 12 | 2,716
malignant mesothelioma 12 | 3,232
pancreatic cancer 11 | 2,398
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 9 | 3,578
Liver Cirrhosis, Experimental 9 | 769
Vascular disease 9 | 319
invasive ductal carcinoma 9 | 2,951
periodontitis 9 | 293
primary pancreatic ductal adenocarcinoma 9 | 1,109
Atopic dermatitis 8 | 952
Autosomal recessive predisposition 8 | 1,442
Lung disease 8 | 142
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung cancer 8 | 4,740
Periodontal disease 7 | 40
adult high grade glioma 7 | 3,801
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
Degenerative disc disease 6 | 35
Endometriosis 6 | 540
Heart disease 6 | 306
Hypertension 6 | 396
Neoplasm Invasiveness 6 | 161
ductal carcinoma in situ 6 | 1,745
Breast Neoplasms 5 | 445
Calcinosis 5 | 70
Kidney disease 5 | 430
Liver disease 5 | 237
Mammary Neoplasms 5 | 425
Multiple Sclerosis 5 | 540
Neoplasm Metastasis 5 | 168
Osteoporosis 5 | 363
Schizophrenia 5 | 1,160
cutaneous lupus erythematosus 5 | 1,057
gastric carcinoma 5 | 807
pituitary cancer 5 | 1,972
Abortion, Spontaneous 4 | 109
Aortic aneurysm 4 | 38
Asthma 4 | 385
Atherosclerosis 4 | 291
Bipolar Disorder 4 | 666
Cholestasis, Extrahepatic 4 | 25
Coronary artery disease 4 | 268
Dental caries 4 | 164
Diabetes Mellitus, Experimental 4 | 108
Duchenne muscular dystrophy 4 | 601
Eye disease 4 | 62
Hypertensive disease 4 | 292
Kidney cancer 4 | 2,613
Oral Submucous Fibrosis 4 | 20
Rheumatoid arthritis 4 | 1,191
Short stature 4 | 531
Spontaneous abortion 4 | 113
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
esophageal adenocarcinoma 4 | 737
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
inflammatory breast cancer 4 | 286
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Becker muscular dystrophy 3 | 191
Cerebrovascular disease 3 | 238
Contact Dermatitis 3 | 81
Dermatitis, Contact 3 | 71
Gingival Hyperplasia 3 | 34
Gingival Hypertrophy 3 | 34
Gingival Overgrowth 3 | 36
Glaucoma 3 | 239
Hypersensitivity reaction type II disease 3 | 253
Infantile onset 3 | 238
Inflammatory bowel disease 3 | 151
Melanoma 3 | 711
Prostate cancer 3 | 175
Prostatic Neoplasms 3 | 495
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010

Tissue

Digestive Tract 33 | 17,369
Female tissues 33 | 17,400
Respiratory system 33 | 16,393
Urinary Tract 33 | 16,678
Blood and immune system 32 | 16,909
Endocrine System 32 | 18,159
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Skin and soft tissues 32 | 17,230
Nervous System 30 | 16,725
Cardiovascular System 27 | 15,192

Target Family

Enzyme 28 | 4,145
Non-IDG 5 | 12,091

Reactome Pathway

Activation of Matrix Metallopr... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433
Matrix metalloproteinase-17 MMP17 Tchem Enzyme -1.40823 27.2 217
Matrix metalloproteinase-15 MMP15 Tchem Enzyme -1.69065 43.4 351
Stromelysin-3 MMP11 Tchem Non-IDG -2.72089 515.7 385
Matrix metalloproteinase-16 MMP16 Tchem Enzyme -1.80934 59.5 301
Matrix metalloproteinase-25 MMP25 Tchem Enzyme -1.53331 37.0 185
Neutrophil elastase ELANE Tclin Enzyme -3.61753 3958.4 411
Tryptase beta-2 TPSAB1 Tbio Enzyme -1.80526 113.0 66
Neutrophil collagenase MMP8 Tchem Enzyme -3.40955 2433.7 483