Development Level

Tbio 65 | 11,651
Tdark 9 | 6,593
Tchem 6 | 1,388
Tclin 5 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 3 | 499
abnormal tooth morphology 2 | 24
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal social-conspecific in... 1 | 3
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased IgG1 level 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased cardiac stroke volum... 1 | 6
decreased caudal vertebrae num... 1 | 53
decreased circulating creatine... 1 | 4
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
small spleen 1 | 19
small testis 1 | 58

Disease

ovarian cancer 47 | 8,520
Carcinoma 46 | 11,493
osteosarcoma 36 | 7,950
psoriasis 34 | 6,694
Breast cancer 30 | 3,578
Cancer 27 | 2,499
lung cancer 27 | 4,740
glioblastoma 26 | 5,792
malignant mesothelioma 21 | 3,232
atypical teratoid / rhabdoid tumor 20 | 5,112
medulloblastoma, large-cell 18 | 6,241
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
pancreatic cancer 16 | 2,398
Kidney cancer 15 | 2,613
lung adenocarcinoma 15 | 2,716
Multiple myeloma 14 | 1,332
breast carcinoma 14 | 1,638
ependymoma 14 | 4,679
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 13 | 2,890
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
adult high grade glioma 11 | 3,801
cystic fibrosis 11 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Schizophrenia 10 | 1,160
ductal carcinoma in situ 10 | 1,745
group 4 medulloblastoma 10 | 1,855
Cleft Palate 9 | 271
Intellectual disability 9 | 1,016
astrocytoma 9 | 1,146
lung carcinoma 9 | 2,843
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 9 | 3,035
Muscle hypotonia 8 | 571
Pick disease 8 | 1,894
Strabismus 8 | 270
acute myeloid leukemia 8 | 783
interstitial cystitis 8 | 2,312
subependymal giant cell astrocytoma 8 | 2,287
Astrocytoma, Pilocytic 7 | 3,081
Cryptorchidism 7 | 296
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
astrocytic glioma 7 | 2,597
colon cancer 7 | 1,478
diabetes mellitus 7 | 1,728
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Autistic Disorder 6 | 364
Bladder Neoplasm 6 | 112
Cognitive delay 6 | 608
Esophageal Squamous Cell Carcinoma 6 | 77
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Kabuki syndrome 6 | 27
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Short stature 6 | 531
Small head 6 | 374
Squamous cell carcinoma of esophagus 6 | 77
Stomach Neoplasms 6 | 300
Urinary Bladder Neoplasms 6 | 114
Waldenstrons macroglobulinemia 6 | 765
cutaneous lupus erythematosus 6 | 1,057
non-small cell lung carcinoma 6 | 317
spina bifida 6 | 1,074
Acquired scoliosis 5 | 281
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Broad flat nasal bridge 5 | 236
Carcinoma, Transitional Cell 5 | 32
Craniofacial Abnormalities 5 | 151
Curvature of spine 5 | 282
Endometriosis 5 | 540
Epilepsy 5 | 792
Feeding difficulties in infancy 5 | 175
Immune system cancer 5 | 140
Lymphoid leukemia 5 | 160
Melanoma 5 | 711
Nasal bridge wide 5 | 236
Obesity 5 | 678
Prominent fingertip pads 5 | 6
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
pancreatic carcinoma 5 | 562
dermatomyositis 4 | 966
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 85 | 18,159
Digestive Tract 84 | 17,369
Skin and soft tissues 84 | 17,230
Blood and immune system 83 | 16,909
Female tissues 83 | 17,400
Urinary Tract 83 | 16,678
Liver and Pancreas 82 | 16,750
Male tissues 82 | 17,142
Respiratory system 82 | 16,393
Nervous System 78 | 16,725
Cardiovascular System 77 | 15,192

Target Family

Non-IDG 36 | 12,091
Transcription Factor 24 | 1,400
Enzyme 13 | 4,145
Epigenetic 8 | 242
Nuclear Receptor 4 | 48

Reactome Pathway

Activation of HOX genes during... 85 | 85
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.80737 619.7 475
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213
Pre-B-cell leukemia transcription factor 1 PBX1 Tbio Transcription Factor -2.30640 200.0 232
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
CCR4-NOT transcription complex subunit 6 CNOT6 Tbio Non-IDG -1.27015 19.4 125
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Transcription factor MafB MAFB Tbio Transcription Factor -2.01655 101.2 191
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA-directed RNA polymerase II subunit RPB4 POLR2D Tbio Enzyme -0.53756 3.34 136