Development Level

Tbio 18 | 10,625
Tchem 14 | 1,890
Tdark 5 | 7,003
Tclin 2 | 602

Collection

Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased lean body mass 1 | 195
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
limb grasping 1 | 35
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

medulloblastoma, large-cell 24 | 6,234
glioblastoma 19 | 5,572
primitive neuroectodermal tumor 19 | 3,031
osteosarcoma 17 | 7,933
pilocytic astrocytoma 17 | 3,086
psoriasis 17 | 6,685
atypical teratoid / rhabdoid tumor 16 | 4,369
ovarian cancer 16 | 8,491
ependymoma 15 | 2,514
oligodendroglioma 15 | 2,849
subependymal giant cell astrocytoma 15 | 2,287
group 3 medulloblastoma 12 | 2,254
astrocytic glioma 11 | 2,241
pediatric high grade glioma 11 | 2,712
pituitary cancer 11 | 1,972
Breast cancer 10 | 3,098
interstitial cystitis 10 | 2,299
invasive ductal carcinoma 10 | 2,950
lung carcinoma 10 | 2,844
Pick disease 9 | 1,893
adult high grade glioma 9 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
lung cancer 9 | 4,473
non-small cell lung cancer 8 | 2,798
breast carcinoma 7 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
malignant mesothelioma 7 | 3,163
medulloblastoma 7 | 1,524
pancreatic cancer 7 | 2,300
Carcinoma 6 | 2,147
astrocytoma 6 | 1,493
atypical teratoid/rhabdoid tumor 6 | 1,095
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung adenocarcinoma 6 | 2,714
Schnyder Corneal Dystrophy 5 | 24
posterior fossa group A ependymoma 5 | 1,511
ulcerative colitis 5 | 2,087
Acquired metabolic disease 4 | 267
Atrial Fibrillation 4 | 110
Duchenne muscular dystrophy 4 | 602
Rheumatoid Arthritis 4 | 1,170
gastric carcinoma 4 | 832
group 4 medulloblastoma 4 | 1,875
sonic hedgehog group medulloblastoma 4 | 1,482
Alcohol dependence 3 | 107
Down syndrome 3 | 548
Hyperactive behavior 3 | 31
Intellectual disability 3 | 573
Long QT syndrome 3 | 53
Multiple myeloma 3 | 1,327
Pain agnosia 3 | 99
Substance Withdrawal Syndrome 3 | 55
adrenocortical carcinoma 3 | 1,427
chronic rhinosinusitis 3 | 512
colon cancer 3 | 1,475
cystic fibrosis 3 | 1,670
diabetes mellitus 3 | 1,663
glioblastoma multiforme 3 | 347
head and neck cancer 3 | 270
juvenile dermatomyositis 3 | 1,189
mucosa-associated lymphoid tissue lymphoma 3 | 480
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 788
primary pancreatic ductal adenocarcinoma 3 | 1,271
Amnesia 2 | 17
Andersen Syndrome 2 | 2
Andersen Tawil syndrome 2 | 2
Animal Mammary Neoplasms 2 | 135
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Cataplexy and narcolepsy 2 | 3
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Dystonia 2 | 77
EAST syndrome 2 | 5
Epilepsy 2 | 346
Hypertension 2 | 293
Hypertensive disease 2 | 193
Hypokalemia 2 | 40
Hypokalemic periodic paralysis 2 | 13
Juvenile arthritis 2 | 124
Mammary Neoplasms, Experimental 2 | 149
Muscle Spasticity of Cerebral Origin 2 | 8
Muscle Weakness 2 | 92
Muscle spasticity of spinal origin 2 | 8
Narcolepsy 2 | 69
Nerve Degeneration 2 | 73
Obesity 2 | 616
Waldenstrons macroglobulinemia 2 | 764
active ulcerative colitis 2 | 477
acute quadriplegic myopathy 2 | 1,157
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis and chronic rhinosinusitis 2 | 213
dermatomyositis 2 | 966
nephrosclerosis 2 | 329
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
sarcoidosis 2 | 368
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 39 | 17,994
Digestive Tract 39 | 18,472
Endocrine System 39 | 18,511
Female tissues 39 | 18,646
Liver and Pancreas 39 | 18,135
Male tissues 39 | 17,968
Nervous System 39 | 18,560
Skin and soft tissues 39 | 18,114
Urinary Tract 39 | 18,443
Cardiovascular System 38 | 17,957
Respiratory system 38 | 17,483

Target Family

Non-IDG 18 | 11,969
Ion Channel 10 | 341
Enzyme 9 | 4,146
GPCR 2 | 408

Reactome Pathway

Activation of GABAB receptors 39 | 39
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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