Development Level

Tbio 26 | 10,625
Tchem 10 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 12 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 2 | 187
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
cardiovascular system phenotyp... 1 | 35
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 27 | 8,492
malignant mesothelioma 24 | 3,163
lung cancer 23 | 4,473
non-small cell lung cancer 23 | 2,798
group 3 medulloblastoma 22 | 2,254
psoriasis 22 | 6,685
adrenocortical carcinoma 20 | 1,427
medulloblastoma, large-cell 20 | 6,234
osteosarcoma 19 | 7,933
glioblastoma 18 | 5,572
primitive neuroectodermal tumor 18 | 3,031
Breast cancer 15 | 3,099
Cancer 15 | 2,346
pediatric high grade glioma 14 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
nasopharyngeal carcinoma 13 | 1,056
colon cancer 12 | 1,475
atypical teratoid / rhabdoid tumor 11 | 4,369
lung adenocarcinoma 11 | 2,714
ductal carcinoma in situ 10 | 1,745
invasive ductal carcinoma 10 | 2,950
Endometriosis 8 | 535
Seckel syndrome 8 | 35
atypical teratoid/rhabdoid tumor 8 | 1,095
posterior fossa group A ependymoma 8 | 1,511
Meier-Gorlin syndrome 7 | 12
Atopic dermatitis 5 | 944
oligodendroglioma 5 | 2,849
Ataxia telangiectasia 4 | 32
EAR, PATELLA, SHORT STATURE SYNDROME 4 | 6
Microcephaly 4 | 149
Multiple myeloma 4 | 1,328
Waldenstrons macroglobulinemia 4 | 765
astrocytoma 4 | 1,493
sonic hedgehog group medulloblastoma 4 | 1,482
Nijmegen breakage syndrome 3 | 23
Peripheral Neuropathy 3 | 303
adult high grade glioma 3 | 2,148
breast carcinoma 3 | 1,614
dermatomyositis 3 | 967
esophageal adenocarcinoma 3 | 737
pituitary cancer 3 | 1,972
tuberculosis and treatment for 6 months 3 | 686
ulcerative colitis 3 | 2,087
Carcinoma 2 | 2,147
Cervix endometriosis 2 | 3
DiGeorge syndrome 2 | 46
Pick disease 2 | 1,893
Pulmonary emphysema 2 | 34
Rothmund-Thomson syndrome 2 | 22
astrocytic glioma 2 | 2,241
chronic lymphocytic leukemia 2 | 244
cystic fibrosis 2 | 1,670
diabetes mellitus 2 | 1,663
glioblastoma multiforme 2 | 347
juvenile dermatomyositis 2 | 1,189
pancreatic cancer 2 | 2,300
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 789
Acquired immunodeficiency syndrome 1 | 164
Alzheimer's disease 1 | 644
Bacillary angiomatosis 1 | 7
Bipolar Disorder 1 | 266
Bowen-Conradi syndrome 1 | 16
Cerebrovascular disease 1 | 231
Chloracne 1 | 32
Colonic Neoplasms 1 | 126
Dengue disease 1 | 19
Disease of metabolism 1 | 15
Fanconi's anemia 1 | 50
Glaucoma 1 | 135
Gout 1 | 93
IGA Glomerulonephritis 1 | 454
Lactose intolerance 1 | 7
Liver Cirrhosis 1 | 101
Malaria 1 | 140
Mammary Neoplasms 1 | 410
Meier-Gorlin syndrome 3 1 | 1
Melanoma 1 | 261
Menopause present (finding) 1 | 20
Nonsyndromic deafness 1 | 121
Ocular melanoma 1 | 4
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 335
Premature ovarian failure 1 | 64
Seborrheic keratosis 1 | 6
Typhoid fever 1 | 22
Urologic Neoplasms 1 | 7
Velocardiofacial syndrome 1 | 45
Williams Syndrome 1 | 10
Williams-Beuren syndrome 1 | 45
Xeroderma pigmentosum 1 | 41
active Crohn's disease 1 | 918
acute quadriplegic myopathy 1 | 1,157
blepharophimosis, ptosis, and epicanthus inversus syndrome 1 | 8
facioscapulohumeral dystrophy 1 | 286
inflammatory breast cancer 1 | 404
substance-related disorder 1 | 105
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 37 | 17,995
Cardiovascular System 37 | 17,958
Digestive Tract 37 | 18,473
Endocrine System 37 | 18,512
Female tissues 37 | 18,647
Liver and Pancreas 37 | 18,136
Male tissues 37 | 17,969
Nervous System 37 | 18,561
Respiratory system 37 | 17,484
Skin and soft tissues 37 | 18,115
Urinary Tract 37 | 18,444

Target Family

Non-IDG 30 | 11,969
Kinase 4 | 634
Enzyme 3 | 4,146

Reactome Pathway

Activation of ATR in response ... 37 | 37
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA helicase MCM8 MCM8 Tbio Enzyme -1.40351 25.2 159
Cell division control protein 6 homolog CDC6 Tchem Non-IDG -2.49821 321.6 473
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.13819 136.3 864
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.46324 281.9 299
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 27.9 132
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.55226 3.38 154
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.37555 26.1 158
ATR-interacting protein ATRIP Tbio Non-IDG -1.59835 40.9 328
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.05436 1.38 29
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.77275 513.9 350