Development Level

Tbio 28 | 11,651
Tchem 7 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 3 | 220
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
embryonic growth retardation 2 | 106
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin morphology 1 | 50
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 28 | 11,493
group 3 medulloblastoma 26 | 4,104
ovarian cancer 26 | 8,520
malignant mesothelioma 24 | 3,232
lung cancer 22 | 4,740
non-small cell lung cancer 22 | 2,890
psoriasis 22 | 6,694
adrenocortical carcinoma 20 | 1,428
medulloblastoma, large-cell 20 | 6,241
glioblastoma 19 | 5,792
osteosarcoma 19 | 7,950
primitive neuroectodermal tumor 18 | 3,035
atypical teratoid / rhabdoid tumor 17 | 5,112
Breast cancer 16 | 3,578
Cancer 14 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
nasopharyngeal carcinoma 13 | 1,058
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
adult high grade glioma 11 | 3,801
colon cancer 11 | 1,478
lung adenocarcinoma 11 | 2,716
ductal carcinoma in situ 10 | 1,745
invasive ductal carcinoma 10 | 2,951
Endometriosis 8 | 540
ependymoma 8 | 4,679
Meier-Gorlin syndrome 7 | 10
Seckel syndrome 7 | 34
Autosomal recessive predisposition 6 | 1,442
Small head 6 | 374
pediatric high grade glioma 6 | 1,064
Atopic dermatitis 5 | 952
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 7
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
oligodendroglioma 5 | 2,850
Ataxia telangiectasia 4 | 34
Birth length less than 3rd percentile 4 | 6
Congenital small ears 4 | 48
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
Hypoplastic mandible condyle 4 | 275
Isolated growth hormone deficiency 4 | 30
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Multiple myeloma 4 | 1,332
Pediatric failure to thrive 4 | 365
Slender, gracile long tubular bones 4 | 21
Waldenstrons macroglobulinemia 4 | 765
astrocytoma 4 | 1,146
Congenital hypoplasia of breast 3 | 25
Cryptorchidism 3 | 296
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Feeding difficulties 3 | 127
Full lower lip 3 | 64
Gastroesophageal reflux disease 3 | 110
Heartburn 3 | 78
Hypertrophy of clitoris 3 | 40
Hypoplasia of the maxilla 3 | 66
Hypotrophic maxilla 3 | 66
Kidney cancer 3 | 2,613
Maxillary retrognathia 3 | 66
Microcephaly 3 | 166
Microstomia 3 | 78
Prominent lower lip 3 | 64
Retrusion of upper jaw bones 3 | 66
breast carcinoma 3 | 1,638
pituitary cancer 3 | 1,972
tuberculosis and treatment for 6 months 3 | 409
ulcerative colitis 3 | 1,819
Abnormality of pelvic girdle bone morphology 2 | 37
Astrocytoma, Pilocytic 2 | 3,081
Bilateral fifth finger clinodactyly 2 | 110
Blepharophimosis 2 | 70
Chronic Lymphocytic Leukemia 2 | 262
Congenital hypoplasia of penis 2 | 176
Curvature of little finger 2 | 110
DiGeorge syndrome 2 | 47
Dull intelligence 2 | 645
Genu varum 2 | 29
Knee joint valgus deformity 2 | 56
Long philtrum 2 | 137
Low intelligence 2 | 645
Low set ears 2 | 181
Mental deficiency 2 | 645
Patella aplasia-hypoplasia 2 | 12
Poor school performance 2 | 645
Pulmonary emphysema 2 | 48
Schizophrenia 2 | 1,160
Strabismus 2 | 270
Triangular face 2 | 58
astrocytic glioma 2 | 2,597
atypical teratoid/rhabdoid tumor 2 | 357
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
pancreatic cancer 2 | 2,398
primary Sjogren syndrome 2 | 735

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Cardiovascular System 34 | 15,192

Target Family

Non-IDG 30 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634

Reactome Pathway

Activation of ATR in response ... 36 | 36
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.15330 141.0 919
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.06074 11.3 79