Development Level

Tbio 13 | 10,625
Tdark 12 | 7,003
Tchem 6 | 1,890
Tclin 1 | 602

IMPC Term

abnormal behavior 1 | 226
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased thermal nociceptive ... 1 | 4
increased B cell number 1 | 23
increased circulating calcium ... 1 | 32
increased circulating serum al... 1 | 25
increased total body fat amoun... 1 | 57
preweaning lethality, complete... 1 | 633
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11

Disease

psoriasis 16 | 6,685
Breast cancer 14 | 3,094
ovarian cancer 13 | 8,484
lung cancer 10 | 4,466
invasive ductal carcinoma 9 | 2,950
lung adenocarcinoma 9 | 2,713
Cancer 8 | 2,346
ductal carcinoma in situ 8 | 1,745
atypical teratoid / rhabdoid tumor 7 | 4,369
breast carcinoma 7 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
Multiple myeloma 6 | 1,327
glioblastoma 6 | 5,572
malignant mesothelioma 6 | 3,162
non-small cell lung carcinoma 6 | 413
osteosarcoma 6 | 7,933
Mammary Neoplasms 5 | 410
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
medulloblastoma, large-cell 5 | 6,234
non-small cell lung cancer 5 | 2,798
pancreatic cancer 5 | 2,300
Prostatic Neoplasms 4 | 471
group 4 medulloblastoma 4 | 1,875
pituitary cancer 4 | 1,972
Carcinoma 3 | 2,147
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Endometriosis 3 | 535
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Neoplasm Recurrence, Local 3 | 23
Prostate cancer 3 | 172
colon cancer 3 | 1,475
group 3 medulloblastoma 3 | 2,254
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
Androgen insensitivity syndrome 2 | 11
Atopic dermatitis 2 | 944
Disease Progression 2 | 125
Gynecomastia 2 | 13
Hypogonadism 2 | 70
Male infertility 2 | 170
Malignant neoplasm of prostate 2 | 67
Obesity 2 | 616
Prostatic hypertrophy 2 | 9
Testicular cancer 2 | 24
Thyroiditis 2 | 25
Urinary bladder cancer 2 | 31
Waldenstrons macroglobulinemia 2 | 765
Withdrawal disorder 2 | 19
diabetes mellitus 2 | 1,663
gastric cancer 2 | 430
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
nasopharyngeal carcinoma 2 | 1,056
pancreatic carcinoma 2 | 567
posterior fossa group A ependymoma 2 | 1,511
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
Acute cystitis 1 | 37
Allergic conjunctivitis 1 | 25
Ankylosing spondylitis 1 | 138
Aplastic anemia 1 | 18
Ataxia telangiectasia 1 | 31
Cyclitis 1 | 6
Diarrhea 1 | 155
Fanconi's anemia 1 | 50
Gestational Diabetes 1 | 17
Hormone receptor positive malignant neoplasm of breast 1 | 10
Hypogonadotropic hypogonadism 1 | 4
Hypopituitarism 1 | 36
Hypospadias 1 | 65
Impotence 1 | 45
Insulin Resistance 1 | 48
Iron metabolism disease 1 | 17
Klinefelter's syndrome 1 | 59
Lymphocele 1 | 7
Malignant tumor of prostate 1 | 11
Metastatic Prostate Carcinoma 1 | 18
Muscular atrophy 1 | 67
Neoplasm Invasiveness 1 | 127
Nephritis 1 | 29
Nephrogenic adenoma 1 | 10
Nijmegen breakage syndrome 1 | 23
Primary ciliary dyskinesia 1 | 73
Proctitis 1 | 11
Prostate disease 1 | 3
Prostatic Intraepithelial Neoplasias 1 | 11
Prostatitis 1 | 15
Pseudohermaphroditism 1 | 16
Seckel syndrome 1 | 34
Squamous cell carcinoma of esophagus 1 | 82
Type 1 diabetes mellitus 1 | 101
Urethral stricture 1 | 7
Uveitis 1 | 103
Vaccinia 1 | 37
Werner syndrome 1 | 29

Tissue

Female tissues 32 | 18,647
Male tissues 32 | 17,969
Blood and immune system 31 | 17,995
Cardiovascular System 31 | 17,958
Digestive Tract 31 | 18,473
Endocrine System 31 | 18,512
Nervous System 31 | 18,561
Urinary Tract 31 | 18,444
Liver and Pancreas 30 | 18,136
Respiratory system 30 | 17,484
Skin and soft tissues 24 | 18,115

Target Family

Non-IDG 26 | 11,971
Enzyme 2 | 4,146
Epigenetic 2 | 242
Kinase 1 | 634
Nuclear Receptor 1 | 48

Reactome Pathway

Activated PKN1 stimulates tran... 32 | 32
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Histone H2A.V H2AFV Tdark Non-IDG -1.20240 14.0 30
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.36 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.48218 30.2 48
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.12825 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2A.J H2AFJ Tdark Non-IDG 0.28 0.61 90
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.31612 18.9 109
Histone H2B type 1-H HIST1H2BH Tdark Non-IDG 1.00 0.56 47
Histone H2A type 1-C HIST1H2AC Tdark Non-IDG -0.12285 0.78 24