Development Level

Tbio 23 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
increased circulating phosphat... 2 | 26
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal forced expiratory flo... 1 | 1
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 20 | 11,493
glioblastoma 17 | 5,792
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 14 | 5,112
osteosarcoma 14 | 7,950
Cancer 13 | 2,499
ovarian cancer 13 | 8,520
lung cancer 12 | 4,740
ependymoma 11 | 4,679
Alzheimer's disease 10 | 658
lung carcinoma 10 | 2,843
primitive neuroectodermal tumor 10 | 3,035
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
oligodendroglioma 8 | 2,850
psoriasis 8 | 6,694
Astrocytoma, Pilocytic 7 | 3,081
malignant mesothelioma 7 | 3,232
Breast cancer 6 | 3,578
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
juvenile dermatomyositis 6 | 1,187
non-small cell lung cancer 6 | 2,890
pediatric high grade glioma 6 | 1,064
Breast Neoplasms 5 | 445
Carcinoma, Pancreatic Ductal 5 | 20
Mammary Neoplasms 5 | 425
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 1,819
Kidney cancer 4 | 2,613
Liver Cirrhosis 4 | 181
gastric carcinoma 4 | 807
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
Adenoid Cystic Carcinoma 3 | 99
Alzheimer Disease 3 | 83
Amyotrophic lateral sclerosis 3 | 451
Anemia 3 | 365
Atopic dermatitis 3 | 952
Bipolar Disorder 3 | 666
Brachydactyly 3 | 156
Carcinoma, Adenoid Cystic 3 | 99
Cataract 3 | 297
Duchenne muscular dystrophy 3 | 601
Failure to gain weight 3 | 365
Hidradenitis suppurativa 3 | 13
Hidradenitis suppurativa, familial 3 | 3
Lens Opacities 3 | 231
Pain agnosia 3 | 104
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Pick's disease 3 | 15
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Short distal phalanges 3 | 50
Strabismus 3 | 270
Syndactyly 3 | 88
Tetralogy of Fallot 3 | 63
acute myeloid leukemia 3 | 783
tuberculosis 3 | 2,010
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Cardiomyopathy, Dilated 2 | 83
Cerebrovascular disease 2 | 238
Dementia 2 | 175
Depressive disorder 2 | 409
Dilated cardiomyopathy 2 | 56
Epilepsy 2 | 792
Frontotemporal dementia 2 | 51
Lice infestation 2 | 15
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Mental Depression 2 | 333
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Reflex, Deep Tendon, Absent 2 | 92
Skin cancer 2 | 469
Sparse hair 2 | 59
Thin, sparse hair 2 | 59
Vascular disease 2 | 319
Ventricular Septal Defects 2 | 119
active Crohn's disease 2 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
posterior fossa group B ependymoma 2 | 416
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Non-IDG 16 | 12,091
Enzyme 14 | 4,145

Reactome Pathway

Activated NOTCH1 Transmits Sig... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable E3 ubiquitin-protein ligase DTX2 DTX2 Tbio Enzyme -1.74890 58.1 123
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.09204 13.1 165
Contactin-1 CNTN1 Tbio Non-IDG -1.93017 87.6 211
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.18767 13.9 219
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.65805 49.1 185
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139