Development Level

Tbio 22 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased circulating sodium l... 1 | 22
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating free fat... 1 | 20

Disease

ovarian cancer 14 | 8,520
Carcinoma 9 | 11,493
lung cancer 9 | 4,740
Multiple myeloma 7 | 1,332
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
diabetes mellitus 5 | 1,728
Hereditary spherocytosis type 5 4 | 12
breast carcinoma 4 | 1,638
Cockayne syndrome 3 | 60
Wolf-Hirschhorn syndrome 3 | 32
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
group 3 medulloblastoma 3 | 4,104
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
Congenital myasthenic syndrome 5 2 | 11
Mixed connective tissue disease 2 | 16
Xeroderma pigmentosum group B 2 | 20
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
primitive neuroectodermal tumor 2 | 3,035
Abnormally-shaped vertebrae 1 | 31
Acquired scoliosis 1 | 281
Allergic hypersensitivity disease 1 | 126
Arachnodactyly 1 | 49
Asthenopia 1 | 10
Atrial Septal Defects 1 | 85
Blepharoptosis 1 | 231
Bowed and upward slanting eyebrows 1 | 41
Broad flat nasal bridge 1 | 236
Chikungunya 1 | 16
Ciliary Dyskinesia, Primary, 1 1 | 27
Claw hand 1 | 26
Congenital Epicanthus 1 | 177
Congenital anomaly of the kidney 1 | 12
Congenital clubfoot 1 | 109
Congenital deafness 1 | 185
Congenital diaphragmatic hernia 1 | 67
Congenital small ears 1 | 48
Curvature of spine 1 | 282
Deafness 1 | 198
Delayed bone age 1 | 136
Downward slant of palpebral fissure 1 | 158
Enamel erosion 1 | 19
Endometriosis of ovary 1 | 5
Epilepsy 1 | 792
Eumycotic mycetoma 1 | 3
Failure to gain weight 1 | 365
Frontal bossing 1 | 157
Fusariosis 1 | 6
Hearing Loss, Partial 1 | 185
Heart valve disease 1 | 39
Hemangioma 1 | 69
High forehead 1 | 102
Hyperkyphosis 1 | 111
Hypersensitivity reaction type II disease 1 | 253
Hypodontia 1 | 81
Hypoplasia of thumb 1 | 26
Kidney Diseases 1 | 114
Kyphosis deformity of spine 1 | 114
La Crosse encephalitis 1 | 5
Long narrow head 1 | 75
Low posterior hairline 1 | 52
Macular degeneration 1 | 65
Megaloblastic anemia 1 | 18
Microcephaly 1 | 166
Microsporidiosis 1 | 13
Multiple Sclerosis 1 | 540
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Nasal bridge wide 1 | 236
Pediatric failure to thrive 1 | 365
Penile hypospadias 1 | 106
Polydactyly preaxial type 1 1 | 9
Reduced fetal movement 1 | 51
Rib fusion 1 | 16
Sacral dimples 1 | 18
Seizures 1 | 596
Severe mental retardation (I.Q. 20-34) 1 | 99
Short philtrum 1 | 53
Subcutaneous mycosis 1 | 2
Tall forehead 1 | 102
Thick, flared eyebrows 1 | 41
Tinea pedis 1 | 29
Turridolichocephaly 1 | 75
hearing impairment 1 | 199
medulloblastoma 1 | 720
sarcoidosis 1 | 370
tuberculosis 1 | 2,010
tuberculosis and treatment for 3 months 1 | 179

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 10 | 12,091

Reactome Pathway

Abortive elongation of HIV-1 t... 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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