Development Level

Tbio 22 | 10,625
Tdark 1 | 7,003

IMPC Term

decreased circulating sodium l... 1 | 18
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating free fat... 1 | 17
preweaning lethality, complete... 1 | 633

Disease

ovarian cancer 14 | 8,484
lung cancer 9 | 4,466
Multiple myeloma 7 | 1,327
osteosarcoma 6 | 7,933
psoriasis 6 | 6,685
diabetes mellitus 5 | 1,663
Wolf-Hirschhorn syndrome 4 | 32
breast carcinoma 4 | 1,614
Breast cancer 3 | 3,094
Cockayne syndrome 3 | 54
acute quadriplegic myopathy 3 | 1,157
astrocytoma 3 | 1,493
lung adenocarcinoma 3 | 2,713
malignant mesothelioma 3 | 3,162
non-small cell lung cancer 3 | 2,798
Carcinoma 2 | 2,147
Mixed connective tissue disease 2 | 16
acute myeloid leukemia 2 | 780
atypical teratoid / rhabdoid tumor 2 | 4,369
glioblastoma 2 | 5,572
group 3 medulloblastoma 2 | 2,254
inflammatory breast cancer 2 | 404
medulloblastoma 2 | 1,524
medulloblastoma, large-cell 2 | 6,234
non primary Sjogren syndrome sicca 2 | 840
primitive neuroectodermal tumor 2 | 3,031
Age related macular degeneration 1 | 84
Allergic hypersensitivity disease 1 | 123
Asthenopia 1 | 11
Asthma 1 | 349
Barrett's esophagus 1 | 183
Buruli ulcer disease 1 | 2
Cataract 1 | 104
Chikungunya 1 | 12
Congenital Cataracts, Facial Dysmorphism, And Neuropathy 1 | 1
Enamel erosion 1 | 15
Endometriosis of ovary 1 | 4
Erdheim-Chester disease 1 | 5
Eumycotic mycetoma 1 | 3
Ewing sarcoma 1 | 26
Fusariosis 1 | 6
Hyperlucent lung 1 | 1
Hypersensitivity reaction type II disease 1 | 235
Hypogonadism 1 | 70
Kuhnt-Junius degeneration 1 | 14
La Crosse encephalitis 1 | 6
Macular degeneration 1 | 41
Megaloblastic anemia 1 | 16
Microcephaly 1 | 149
Myoglobinuria 1 | 11
Neuropathy 1 | 210
Photosensitive trichothiodystrophy 1 | 24
Rheumatoid Arthritis 1 | 1,160
Subcutaneous mycosis 1 | 1
Tinea pedis 1 | 30
Vaccinia 1 | 37
adult high grade glioma 1 | 2,148
astrocytic glioma 1 | 2,241
dermatomyositis 1 | 933
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 2,514
hepatocellular carcinoma 1 | 532
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
invasive ductal carcinoma 1 | 2,950
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
pediatric high grade glioma 1 | 2,712
pilocytic astrocytoma 1 | 3,086
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 1,511
sarcoidosis 1 | 358
sonic hedgehog group medulloblastoma 1 | 1,482
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 1,557
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 23 | 17,995
Cardiovascular System 23 | 17,958
Digestive Tract 23 | 18,473
Endocrine System 23 | 18,512
Female tissues 23 | 18,647
Liver and Pancreas 23 | 18,136
Male tissues 23 | 17,969
Nervous System 23 | 18,561
Respiratory system 23 | 17,484
Skin and soft tissues 23 | 18,115
Urinary Tract 23 | 18,444

Target Family

Enzyme 13 | 4,146
Non-IDG 10 | 11,971

Reactome Pathway

Abortive elongation of HIV-1 t... 23 | 23
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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