Development Level

Tbio 53 | 11,445
Tchem 11 | 1,598
Tdark 4 | 6,588
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal head morphology 3 | 10
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
male infertility 3 | 123
abnormal cranium morphology 2 | 36
decreased bone mineral content 2 | 151
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
embryonic lethality prior to o... 2 | 239
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased leukocyte cell numbe... 1 | 73
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased grip strength 1 | 41
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

ovarian cancer 52 | 8,520
Carcinoma 51 | 11,493
osteosarcoma 39 | 7,950
group 3 medulloblastoma 37 | 4,104
atypical teratoid / rhabdoid tumor 31 | 5,112
psoriasis 31 | 6,694
medulloblastoma, large-cell 29 | 6,241
lung cancer 27 | 4,740
ependymoma 26 | 4,679
glioblastoma 25 | 5,792
malignant mesothelioma 24 | 3,232
primitive neuroectodermal tumor 24 | 3,035
Breast cancer 23 | 3,578
Kidney cancer 23 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
adult high grade glioma 18 | 3,801
colon cancer 18 | 1,478
non-small cell lung cancer 18 | 2,890
oligodendroglioma 18 | 2,850
Intellectual disability 17 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
Pick disease 15 | 1,894
lung adenocarcinoma 14 | 2,716
nasopharyngeal carcinoma 14 | 1,058
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Microcephaly 13 | 166
Cancer 12 | 2,499
Multiple myeloma 12 | 1,332
breast carcinoma 12 | 1,638
invasive ductal carcinoma 12 | 2,951
Astrocytoma, Pilocytic 11 | 3,081
Short stature 11 | 531
astrocytic glioma 11 | 2,597
pancreatic cancer 11 | 2,398
Autosomal recessive predisposition 10 | 1,442
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Small head 10 | 374
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
ductal carcinoma in situ 9 | 1,745
Downward slant of palpebral fissure 8 | 158
Epilepsy 8 | 792
Joubert syndrome 8 | 66
Seizures 8 | 596
diabetes mellitus 8 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
Endometriosis 7 | 540
Waldenstrons macroglobulinemia 7 | 765
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
juvenile dermatomyositis 7 | 1,187
Dilated ventricles (finding) 6 | 121
Glaucoma 6 | 239
Muscle hypotonia 6 | 571
Obesity 6 | 678
Pachygyria 6 | 41
astrocytoma 6 | 1,146
dermatomyositis 6 | 966
interstitial cystitis 6 | 2,312
non primary Sjogren syndrome sicca 6 | 891
subependymal giant cell astrocytoma 6 | 2,287
Agenesis of corpus callosum 5 | 83
Anteverted nostril 5 | 191
Atopic dermatitis 5 | 952
Cataract 5 | 297
Hypertensive disease 5 | 292
Increase in blood pressure 5 | 119
Lens Opacities 5 | 231
Lissencephaly 5 | 69
MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 1 5 | 16
Microcephalic osteodysplastic primordial dwarfism type II 5 | 13
Nephronophthisis 5 | 80
Seckel syndrome 5 | 34
Severe mental retardation (I.Q. 20-34) 5 | 99
Sloping forehead 5 | 46
acute myeloid leukemia 5 | 783
esophageal adenocarcinoma 5 | 737
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
posterior fossa group B ependymoma 5 | 416
progressive supranuclear palsy 5 | 676
tuberculosis and treatment for 6 months 5 | 409
Bilateral fifth finger clinodactyly 4 | 110
Bipolar Disorder 4 | 666
Congenital Epicanthus 4 | 177
Duchenne muscular dystrophy 4 | 601
Hypoplastic mandible condyle 4 | 275
Intrauterine retardation 4 | 176
Low set ears 4 | 181
Mandibular hypoplasia 4 | 275
Rheumatoid arthritis 4 | 1,191
chronic rhinosinusitis 4 | 512
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 71 | 16,909
Cardiovascular System 71 | 15,192
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Liver and Pancreas 71 | 16,750
Male tissues 71 | 17,142
Nervous System 71 | 16,725
Respiratory system 71 | 16,393
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678

Target Family

Non-IDG 59 | 12,091
Kinase 8 | 634
Enzyme 4 | 4,145

Reactome Pathway

AURKA Activation by TPX2 71 | 71
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -2.03755 107.9 152
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.78486 61.9 82
Centrosomal protein of 41 kDa CEP41 Tdark Non-IDG -0.41185 3.40 46
HAUS augmin-like complex subunit 5 HAUS5 Tbio Non-IDG 0.34 0.65 77
Centrosomal protein of 152 kDa CEP152 Tbio Non-IDG -1.23896 18.1 117