Development Level

Tbio 20 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal vitreous body morphol... 1 | 10
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased heart weight 1 | 62
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 17 | 8,520
osteosarcoma 16 | 7,950
psoriasis 12 | 6,694
Cancer 8 | 2,499
diabetes mellitus 8 | 1,728
glioblastoma 8 | 5,792
group 3 medulloblastoma 8 | 4,104
lung cancer 8 | 4,740
malignant mesothelioma 8 | 3,232
Carcinoma 7 | 11,493
atypical teratoid / rhabdoid tumor 7 | 5,112
Obesity 6 | 678
medulloblastoma, large-cell 6 | 6,241
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Multiple myeloma 4 | 1,332
Vascular disease 4 | 319
acute myeloid leukemia 4 | 783
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung cancer 4 | 2,890
periodontitis 4 | 293
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Cerebral atrophy 3 | 178
Cognitive delay 3 | 608
Depressive disorder 3 | 409
Endometriosis 3 | 540
Fatty Liver 3 | 70
Global developmental delay 3 | 608
Hypertension 3 | 396
Influenza 3 | 142
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Mental Depression 3 | 333
Mental and motor retardation 3 | 608
Prostatic Neoplasms 3 | 495
Pulmonary Fibrosis 3 | 106
Rheumatoid arthritis 3 | 1,191
astrocytoma 3 | 1,146
ependymoma 3 | 4,679
gastric cancer 3 | 459
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung carcinoma 3 | 2,843
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Alcoholic Intoxication, Chronic 2 | 289
Allergic hypersensitivity disease 2 | 126
Alzheimer's disease 2 | 658
Anemia 2 | 365
Arthritis 2 | 290
Atherosclerosis 2 | 291
Cerebrovascular disease 2 | 238
Coronary artery disease 2 | 268
Dermatitis 2 | 157
Eye disease 2 | 62
Failure to gain weight 2 | 365
Heart disease 2 | 306
Hyperalgesia 2 | 83
Hypersensitivity reaction type II disease 2 | 253
Infertility 2 | 188
Inflammatory bowel disease 2 | 151
Influenza, Human 2 | 51
Liver Cirrhosis 2 | 181
Liver neoplasms 2 | 130
Low Vision 2 | 174
Lung disease 2 | 142
Malaria 2 | 160
Multiple Sclerosis 2 | 540
Neurodegenerative disease 2 | 414
Pediatric failure to thrive 2 | 365
Peritonitis 2 | 43
Pontocerebellar hypoplasia 2 | 36
Reperfusion Injury 2 | 86
Stomach Neoplasms 2 | 300
Vasculitis 2 | 80
Visual Impairment 2 | 174
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
adrenocortical adenoma 2 | 131
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
head and neck cancer 2 | 271
lung adenocarcinoma 2 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
spina bifida 2 | 1,074
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 8 | 12,091
Transcription Factor 7 | 1,400

Reactome Pathway

ATF4 activates genes 24 | 24
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.94434 736.0 704
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
Cyclic AMP-dependent transcription factor ATF-3 ATF3 Tbio Transcription Factor -2.67021 520.8 401
Nuclear transcription factor Y subunit gamma NFYC Tbio Transcription Factor -1.89858 75.4 191