Development Level

Tbio 133 | 10,625
Tchem 61 | 1,890
Tclin 40 | 602
Tdark 6 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 633
decreased body weight 7 | 174
decreased total body fat amoun... 6 | 186
abnormal bone structure 4 | 131
decreased bone mineral content 4 | 157
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
decreased kidney weight 3 | 7
decreased lean body mass 3 | 195
decreased lumbar vertebrae num... 3 | 62
thrombocytopenia 3 | 46
abnormal coat-hair pigmentatio... 2 | 54
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
impaired pupillary reflex 2 | 14
increased circulating HDL chol... 2 | 63
increased circulating phosphat... 2 | 24
increased lean body mass 2 | 107
increased startle reflex 2 | 38
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
cleft palate 1 | 6
corneal opacity 1 | 25
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased prepulse inhibition 1 | 52
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
mydriasis 1 | 9
narrow eye opening 1 | 15
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
short tibia 1 | 82
sparse hair 1 | 6
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 135 | 8,491
osteosarcoma 126 | 7,933
glioblastoma 103 | 5,572
psoriasis 101 | 6,685
Cancer 99 | 2,346
medulloblastoma, large-cell 94 | 6,234
lung cancer 91 | 4,473
atypical teratoid / rhabdoid tumor 68 | 4,369
Breast cancer 60 | 3,098
malignant mesothelioma 60 | 3,163
pilocytic astrocytoma 59 | 3,086
oligodendroglioma 57 | 2,849
Carcinoma 54 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 54 | 3,289
invasive ductal carcinoma 52 | 2,950
pediatric high grade glioma 52 | 2,712
ependymoma 51 | 2,514
lung adenocarcinoma 49 | 2,714
astrocytic glioma 46 | 2,241
Multiple myeloma 45 | 1,327
interstitial cystitis 45 | 2,299
lung carcinoma 45 | 2,844
subependymal giant cell astrocytoma 45 | 2,287
non-small cell lung cancer 44 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,956
pancreatic cancer 40 | 2,300
primitive neuroectodermal tumor 39 | 3,031
ulcerative colitis 39 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
diabetes mellitus 33 | 1,663
cystic fibrosis 32 | 1,670
tuberculosis 32 | 1,563
astrocytoma 31 | 1,493
group 3 medulloblastoma 31 | 2,254
pituitary cancer 31 | 1,972
Pick disease 29 | 1,893
medulloblastoma 29 | 1,524
breast carcinoma 28 | 1,614
ductal carcinoma in situ 28 | 1,745
group 4 medulloblastoma 28 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,795
Rheumatoid Arthritis 27 | 1,170
colon cancer 24 | 1,475
primary pancreatic ductal adenocarcinoma 24 | 1,271
adult high grade glioma 22 | 2,148
Mammary Neoplasms 21 | 410
Schizophrenia 21 | 503
juvenile dermatomyositis 20 | 1,189
posterior fossa group B ependymoma 20 | 1,530
Parkinson's disease 19 | 364
Intellectual disability 18 | 573
Waldenstrons macroglobulinemia 18 | 764
dermatomyositis 18 | 966
gastric carcinoma 18 | 832
adrenocortical carcinoma 17 | 1,427
cutaneous lupus erythematosus 17 | 1,056
non primary Sjogren syndrome sicca 17 | 840
non-small cell lung carcinoma 17 | 413
HIV Infections 16 | 99
Lung Neoplasms 16 | 171
atypical teratoid/rhabdoid tumor 16 | 1,095
esophageal adenocarcinoma 16 | 737
spina bifida 16 | 1,064
Alzheimer's disease 15 | 644
Liver carcinoma 15 | 217
posterior fossa group A ependymoma 15 | 1,511
Autistic Disorder 14 | 320
Neoplasm Invasiveness 14 | 127
Peripheral Neuropathy 14 | 303
Prostatic Neoplasms 14 | 471
Renal Cell Carcinoma 14 | 199
Stomach Neoplasms 14 | 282
tuberculosis and treatment for 6 months 14 | 686
Asthma 13 | 349
Myocardial Ischemia 13 | 169
Noonan Syndrome 13 | 33
Osteoporosis 13 | 259
hepatocellular carcinoma 13 | 550
sonic hedgehog group medulloblastoma 13 | 1,482
Anemia 12 | 252
Animal Mammary Neoplasms 12 | 135
Down syndrome 12 | 548
Hirschsprung's disease 12 | 44
Mammary Neoplasms, Experimental 12 | 149
Melanoma 12 | 261
Vascular disease 12 | 281
fibroadenoma 12 | 557
primary Sjogren syndrome 12 | 788
Atopic dermatitis 11 | 944
Cleft palate 11 | 125
Heart disease 11 | 279
Multiple Sclerosis 11 | 498
Thrombocytopenia 11 | 105
Toxic encephalopathy 11 | 131
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
inflammatory breast cancer 11 | 404
pancreatic carcinoma 11 | 567
Crohn's disease 10 | 304
Obesity 10 | 616
gastric cancer 10 | 436

Tissue

Endocrine System 240 | 18,511
Female tissues 240 | 18,646
Nervous System 240 | 18,560
Digestive Tract 239 | 18,472
Urinary Tract 239 | 18,443
Liver and Pancreas 238 | 18,135
Blood and immune system 237 | 17,994
Skin and soft tissues 237 | 18,114
Cardiovascular System 236 | 17,957
Male tissues 235 | 17,968
Respiratory system 231 | 17,483

Target Family

Non-IDG 119 | 11,969
Enzyme 79 | 4,146
Kinase 37 | 634
Ion Channel 5 | 341

Reactome Pathway

ARMS-mediated activation 240 | 240
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46