Development Level

Tbio 21 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 3 | 220
embryonic growth retardation 3 | 106
anophthalmia 2 | 33
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
brachydactyly 1 | 19
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged lymph nodes 1 | 37
increased circulating alanine ... 1 | 13
increased circulating glucose ... 1 | 24
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
syndactyly 1 | 23

Disease

ovarian cancer 17 | 8,520
lung cancer 12 | 4,740
Carcinoma 11 | 11,493
glioblastoma 10 | 5,792
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
adrenocortical carcinoma 8 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Breast cancer 7 | 3,578
Cancer 7 | 2,499
atypical teratoid / rhabdoid tumor 7 | 5,112
group 3 medulloblastoma 7 | 4,104
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
ependymoma 6 | 4,679
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
Atopic dermatitis 5 | 952
Endometriosis 5 | 540
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
malignant mesothelioma 5 | 3,232
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
Cataract 3 | 297
Dull intelligence 3 | 645
Glaucoma 3 | 239
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Lens Opacities 3 | 231
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
Poor school performance 3 | 645
active Crohn's disease 3 | 922
esophageal adenocarcinoma 3 | 737
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Abnormality of vision 2 | 40
Abnormally small eyeball 2 | 97
Anemia 2 | 365
Anteverted nostril 2 | 191
Ascites 2 | 22
Autosomal recessive predisposition 2 | 1,442
Cleft Palate 2 | 271
Clouding of corneal stroma 2 | 50
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Congenital hypoplasia of penis 2 | 176
Corneal Opacity 2 | 53
Dandy-Walker Syndrome 2 | 39
Decreased size of eyeball 2 | 97
Esophageal Squamous Cell Carcinoma 2 | 77
Global developmental delay 2 | 608
Increased nuchal translucency 2 | 6
Kidney cancer 2 | 2,613
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2 | 5
Mental and motor retardation 2 | 608
Microphthalmos 2 | 100
Muscle biopsy shows dystrophic changes 2 | 39
Muscular dystrophy 2 | 75
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Nystagmus 2 | 317
Pick's disease 2 | 15
Polyhydramnios 2 | 108
Profound Mental Retardation 2 | 31
Profound intellectual disabilities 2 | 31
Short stature 2 | 531
Small head 2 | 374
Squamous cell carcinoma of esophagus 2 | 77
Triangular face 2 | 58
Uranostaphyloschisis 2 | 167
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung carcinoma 2 | 2,843
mosaic variegated aneuploidy syndrome 1 2 | 4
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 9 | 4,145
Kinase 2 | 634

Reactome Pathway

APC-Cdc20 mediated degradation... 24 | 24
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Anaphase-promoting complex subunit 10 ANAPC10 Tbio Enzyme -1.23751 18.1 156
Anaphase-promoting complex subunit 11 ANAPC11 Tbio Enzyme -1.27406 17.9 239
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 27