Development Level

Tbio 54 | 10,625
Tchem 23 | 1,890
Tclin 5 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 5 | 187
embryonic lethality prior to o... 4 | 148
abnormal embryo size 3 | 112
embryonic growth retardation 3 | 28
anophthalmia 2 | 20
increased mean corpuscular vol... 2 | 91
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal hindbrain morphology 1 | 2
abnormal kidney morphology 1 | 30
abnormal midbrain morphology 1 | 2
abnormal neural tube closure 1 | 37
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal skin coloration 1 | 18
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating glucose ... 1 | 121
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
edema 1 | 11
enlarged lymph nodes 1 | 27
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
microphthalmia 1 | 15
pallor 1 | 13
prenatal lethality 1 | 16
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 62 | 8,492
psoriasis 43 | 6,685
lung cancer 41 | 4,473
glioblastoma 38 | 5,572
osteosarcoma 37 | 7,933
Multiple myeloma 29 | 1,328
medulloblastoma, large-cell 29 | 6,234
Cancer 26 | 2,346
Breast cancer 22 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
malignant mesothelioma 21 | 3,163
non-small cell lung cancer 21 | 2,798
invasive ductal carcinoma 20 | 2,950
pediatric high grade glioma 20 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
adrenocortical carcinoma 17 | 1,427
atypical teratoid / rhabdoid tumor 17 | 4,369
lung adenocarcinoma 17 | 2,714
primitive neuroectodermal tumor 16 | 3,031
HIV Infections 15 | 100
colon cancer 14 | 1,475
pancreatic cancer 14 | 2,300
Endometriosis 13 | 535
Waldenstrons macroglobulinemia 13 | 765
posterior fossa group A ependymoma 13 | 1,511
Atopic dermatitis 12 | 944
breast carcinoma 12 | 1,614
dermatomyositis 12 | 967
group 3 medulloblastoma 12 | 2,254
ductal carcinoma in situ 11 | 1,745
primary Sjogren syndrome 11 | 789
IGA Glomerulonephritis 10 | 454
oligodendroglioma 10 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
astrocytoma 9 | 1,493
nasopharyngeal carcinoma 9 | 1,056
sonic hedgehog group medulloblastoma 9 | 1,482
astrocytic glioma 8 | 2,241
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 1,524
non primary Sjogren syndrome sicca 8 | 840
pilocytic astrocytoma 8 | 3,086
ulcerative colitis 8 | 2,087
Pick disease 7 | 1,893
atypical teratoid/rhabdoid tumor 7 | 1,095
diabetes mellitus 7 | 1,663
interstitial cystitis 7 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
active Crohn's disease 6 | 918
ependymoma 6 | 2,514
Mantle cell lymphoma 5 | 20
acute quadriplegic myopathy 5 | 1,157
cutaneous lupus erythematosus 5 | 1,056
lung carcinoma 5 | 2,844
primary pancreatic ductal adenocarcinoma 5 | 1,271
subependymal giant cell astrocytoma 5 | 2,287
Peripheral Neuropathy 4 | 303
Squamous cell carcinoma of esophagus 4 | 82
acute myeloid leukemia 4 | 785
juvenile dermatomyositis 4 | 1,189
pituitary cancer 4 | 1,972
tuberculosis 4 | 1,563
Mammary Neoplasms, Experimental 3 | 150
Osteoporosis 3 | 259
Polycystic Ovary Syndrome 3 | 335
Rheumatoid Arthritis 3 | 1,171
inflammatory breast cancer 3 | 404
posterior fossa group B ependymoma 3 | 1,530
progressive supranuclear palsy 3 | 674
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
Carcinoma of colon 2 | 32
Colorectal Neoplasms 2 | 217
Diffuse large B-cell lymphoma 2 | 42
Duchenne muscular dystrophy 2 | 602
Liver carcinoma 2 | 217
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2 | 4
Mammary Neoplasms 2 | 410
Melanoma 2 | 261
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Parkinson's disease 2 | 364
Pick's disease 2 | 14
Stevens-Johnson syndrome 2 | 91
adult high grade glioma 2 | 2,148
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,670
gastric cancer 2 | 436
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
mosaic variegated aneuploidy syndrome 1 2 | 4
sarcoidosis 2 | 368
tuberculosis and treatment for 6 months 2 | 686
Degenerative polyarthritis 1 | 93
Retinitis pigmentosa 1 | 156
Sjogren's syndrome 1 | 23
cystic fibrosis and chronic rhinosinusitis 1 | 213
limb girdle muscular dystrophy 2B 1 | 74
systemic lupus erythematosus 1 | 172

Tissue

Blood and immune system 85 | 17,995
Digestive Tract 85 | 18,473
Endocrine System 85 | 18,512
Female tissues 85 | 18,647
Liver and Pancreas 85 | 18,136
Male tissues 85 | 17,969
Nervous System 85 | 18,561
Urinary Tract 85 | 18,444
Cardiovascular System 84 | 17,958
Respiratory system 84 | 17,484
Skin and soft tissues 84 | 18,115

Target Family

Enzyme 52 | 4,146
Non-IDG 26 | 11,969
Kinase 7 | 634

Reactome Pathway

APC/C-mediated degradation of ... 85 | 85
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 20 homolog CDC20 Tbio Non-IDG -2.58287 383.9 269
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.06059 1176.3 707
Mitotic checkpoint protein BUB3 BUB3 Tbio Non-IDG -1.91281 73.2 222
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.86105 71.4 158
26S protease regulatory subunit 6A PSMC3 Tbio Enzyme -1.26468 18.5 271
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.44048 25.4 280
F-box only protein 5 FBXO5 Tbio Non-IDG -1.70254 55.4 110
Securin PTTG1 Tbio Non-IDG -2.39265 244.3 267