Development Level

Tchem 7 | 1,598
Tbio 4 | 11,445
Tclin 2 | 613

IMPC Phenotype

decreased body weight 2 | 161
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased body length 1 | 101
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 10 | 2,499
Carcinoma 10 | 11,493
ovarian cancer 9 | 8,520
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
subependymal giant cell astrocytoma 7 | 2,287
Prostatic Neoplasms 6 | 495
glioblastoma 6 | 5,792
Kidney cancer 5 | 2,613
atypical teratoid / rhabdoid tumor 5 | 5,112
medulloblastoma, large-cell 5 | 6,241
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
lung cancer 4 | 4,740
Alzheimer's disease 3 | 658
Angiofibroma 3 | 7
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Epilepsy 3 | 792
Mammary Neoplasms 3 | 425
Seizures 3 | 596
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
oligodendroglioma 3 | 2,850
tuberculosis 3 | 2,010
Abdominal pain, episodic 2 | 9
Abnormalities, Multiple 2 | 13
Acromegaly 2 | 51
Adenoma 2 | 167
Adrenal cortical adenoma 2 | 19
Autosomal recessive predisposition 2 | 1,442
Bipolar affective disorder, current episode manic 2 | 13
Bipolar disorder in remission 2 | 19
Breast cancer 2 | 3,578
Colonic Neoplasms 2 | 142
Depressive disorder 2 | 409
Diarrhea 2 | 253
Dull intelligence 2 | 645
Esophagitis 2 | 35
Fever 2 | 138
Growth hormone excess 2 | 14
HIV Infections 2 | 102
Heart conduction disease 2 | 83
Hypercalcemia 2 | 59
Hyperinsulinaemic hypoglycaemia 2 | 16
Hyperinsulinemia, fasting 2 | 7
Hyperparathyroidism 2 | 48
Increased serum parathyroid hormone 2 | 14
Insulinoma 2 | 24
Intestinal Neoplasms 2 | 12
Juvenile rheumatoid arthritis 2 | 111
Kidney Neoplasm 2 | 29
Kidney Neoplasms 2 | 37
Low intelligence 2 | 645
Lung Neoplasms 2 | 232
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple Endocrine Neoplasia Type 1 2 | 29
Multiple myeloma 2 | 1,332
Multiple, subcutaneous nodules 2 | 53
Non-Functioning Pituitary Gland Neoplasm 2 | 6
Osteoarthritis 2 | 184
Pain 2 | 103
Pancreatic Neoplasm 2 | 85
Parathyroid Adenoma 2 | 19
Parathyroid hyperplasia 2 | 6
Parkinson's disease 2 | 392
Peptic Ulcer 2 | 27
Pituitary growth hormone cell adenoma 2 | 8
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Precancerous Conditions 2 | 80
Prolactinoma 2 | 11
Reperfusion Injury 2 | 86
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Stomach Neoplasms 2 | 300
Subcutaneous lipomas 2 | 9
Subcutaneous nodule 2 | 53
Thyroid Gland Follicular Adenoma 2 | 9
Toxic encephalopathy 2 | 141
Transient Ischemic Attack 2 | 10
Tuberous sclerosis 2 | 19
Vascular disease 2 | 319
Zollinger-Ellison syndrome 2 | 18
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
gastric cancer 2 | 459
intermittent abdominal pain 2 | 9
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung carcinoma 2 | 317
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 5 | 4,145
Kinase 5 | 634
Non-IDG 3 | 12,091

Reactome Pathway

AKT phosphorylates targets in ... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase makorin-1 MKRN1 Tbio Enzyme -0.96099 16.4 225
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Tuberin TSC2 Tbio Non-IDG -2.99381 1000.6 1632
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43737 3042.8 1509
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
RAC-beta serine/threonine-protein kinase AKT2 Tchem Kinase -2.60567 332.5 1173