Development Level

Tbio 68 | 10,625
Tchem 24 | 1,890
Tclin 9 | 602
Tdark 3 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 633
vertebral fusion 3 | 23
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
increased mean corpuscular hem... 2 | 93
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal hair growth 1 | 8
abnormal lens morphology 1 | 73
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased total body fat amoun... 1 | 186
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased kidney weight 1 | 4
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
small adrenal glands 1 | 15
vertebral transformation 1 | 12

Disease

ovarian cancer 68 | 8,491
psoriasis 48 | 6,685
osteosarcoma 44 | 7,933
lung cancer 40 | 4,473
glioblastoma 31 | 5,572
Multiple myeloma 30 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
Colorectal Neoplasms 25 | 217
Carcinoma 24 | 2,147
medulloblastoma, large-cell 24 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
malignant mesothelioma 21 | 3,163
Breast cancer 19 | 3,098
atypical teratoid / rhabdoid tumor 18 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
Cancer 17 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
lung carcinoma 17 | 2,844
invasive ductal carcinoma 16 | 2,950
HIV Infections 15 | 99
lung adenocarcinoma 15 | 2,714
Pick disease 13 | 1,893
pediatric high grade glioma 13 | 2,712
Waldenstrons macroglobulinemia 12 | 764
dermatomyositis 12 | 966
diabetes mellitus 12 | 1,663
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
interstitial cystitis 11 | 2,299
pilocytic astrocytoma 11 | 3,086
ulcerative colitis 11 | 2,087
Peripheral Neuropathy 10 | 303
astrocytoma 10 | 1,493
ependymoma 10 | 2,514
Rheumatoid Arthritis 9 | 1,170
non primary Sjogren syndrome sicca 9 | 840
oligodendroglioma 9 | 2,849
ductal carcinoma in situ 8 | 1,745
juvenile dermatomyositis 8 | 1,189
primitive neuroectodermal tumor 8 | 3,031
progressive supranuclear palsy 8 | 674
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 1,563
Alzheimer's disease 7 | 644
Disease Progression 7 | 125
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
cystic fibrosis 7 | 1,670
non-small cell lung carcinoma 7 | 413
posterior fossa group A ependymoma 7 | 1,511
sonic hedgehog group medulloblastoma 7 | 1,482
Cholestasis 6 | 93
active Crohn's disease 6 | 918
gastric cancer 6 | 436
group 3 medulloblastoma 6 | 2,254
posterior fossa group B ependymoma 6 | 1,530
primary pancreatic ductal adenocarcinoma 6 | 1,271
IGA Glomerulonephritis 5 | 454
Mantle cell lymphoma 5 | 20
Neurodegenerative disease 5 | 383
acute myeloid leukemia 5 | 785
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
atypical teratoid/rhabdoid tumor 5 | 1,095
breast carcinoma 5 | 1,614
colon cancer 5 | 1,475
cutaneous lupus erythematosus 5 | 1,056
group 4 medulloblastoma 5 | 1,875
medulloblastoma 5 | 1,524
primary Sjogren syndrome 5 | 788
Adverse reaction to drug 4 | 54
Atherosclerosis 4 | 275
Atopic dermatitis 4 | 944
Down syndrome 4 | 548
Dubin-Johnson syndrome 4 | 6
Endometriosis 4 | 535
Epilepsy 4 | 346
Lipid metabolism disorder 4 | 102
Peroxisomal disease 4 | 20
Pseudoxanthoma elasticum 4 | 19
Tangier disease 4 | 8
aldosterone-producing adenoma 4 | 664
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
hepatocellular carcinoma 4 | 550
pituitary cancer 4 | 1,972
Adrenoleukodystrophy 3 | 31
Amyotrophic Lateral Sclerosis 3 | 432
Cholecystolithiasis 3 | 8
Coronary artery disease 3 | 240
Crohn's disease 3 | 304
Diabetes Mellitus, Non-Insulin-Dependent 3 | 161
Duchenne muscular dystrophy 3 | 602
Liver carcinoma 3 | 217
Prostatic Neoplasms 3 | 471
Vascular disease 3 | 281
mucosa-associated lymphoid tissue lymphoma 3 | 480
non diabetic and post-ischemic heart failure 3 | 200
pancreatic carcinoma 3 | 567
periodontitis 3 | 269

Tissue

Blood and immune system 104 | 17,994
Digestive Tract 104 | 18,472
Endocrine System 104 | 18,511
Female tissues 104 | 18,646
Liver and Pancreas 104 | 18,135
Male tissues 104 | 17,968
Nervous System 104 | 18,560
Urinary Tract 104 | 18,443
Cardiovascular System 103 | 17,957
Respiratory system 103 | 17,483
Skin and soft tissues 103 | 18,114

Target Family

Enzyme 41 | 4,146
Transporter 37 | 473
Non-IDG 23 | 11,969
Ion Channel 2 | 341
Kinase 1 | 634

Reactome Pathway

ABC-family proteins mediated t... 104 | 104
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Erlin-2 ERLIN2 Tbio Non-IDG -1.24133 18.7 148
ATP-binding cassette sub-family A member 8 ABCA8 Tbio Transporter -0.79847 6.34 80
ATP-binding cassette sub-family F member 1 ABCF1 Tbio Transporter -1.12928 13.7 196
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tchem Non-IDG -2.80914 642.9 498
ATP-binding cassette sub-family C member 9 ABCC9 Tclin Transporter -1.57000 37.9 132
Erlin-1 ERLIN1 Tbio Non-IDG -0.93999 8.67 117
ATP-binding cassette sub-family G member 8 ABCG8 Tbio Transporter -2.21122 264.0 185
ATP-binding cassette sub-family G member 5 ABCG5 Tbio Transporter -2.25587 163.6 136