Development Level

Tbio 68 | 10,625
Tchem 25 | 1,890
Tclin 9 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
vertebral fusion 3 | 23
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
increased mean corpuscular hem... 2 | 93
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal hair growth 1 | 8
abnormal lens morphology 1 | 73
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased total body fat amoun... 1 | 186
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased heart rate variabili... 1 | 4
increased hematocrit 1 | 36
increased kidney weight 1 | 4
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
small adrenal glands 1 | 15
vertebral transformation 1 | 12

Disease

ovarian cancer 69 | 8,492
psoriasis 48 | 6,685
osteosarcoma 44 | 7,933
lung cancer 40 | 4,473
Multiple myeloma 31 | 1,328
glioblastoma 31 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
Colorectal Neoplasms 25 | 217
Carcinoma 24 | 2,147
medulloblastoma, large-cell 24 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
malignant mesothelioma 21 | 3,163
Breast cancer 20 | 3,099
atypical teratoid / rhabdoid tumor 18 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
Cancer 17 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
lung carcinoma 17 | 2,844
HIV Infections 16 | 100
invasive ductal carcinoma 16 | 2,950
lung adenocarcinoma 15 | 2,714
Pick disease 13 | 1,893
Waldenstrons macroglobulinemia 13 | 765
dermatomyositis 13 | 967
pediatric high grade glioma 13 | 2,712
diabetes mellitus 12 | 1,663
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
interstitial cystitis 11 | 2,299
pilocytic astrocytoma 11 | 3,086
ulcerative colitis 11 | 2,087
Peripheral Neuropathy 10 | 303
Rheumatoid Arthritis 10 | 1,171
astrocytoma 10 | 1,493
ependymoma 10 | 2,514
non primary Sjogren syndrome sicca 9 | 840
oligodendroglioma 9 | 2,849
ductal carcinoma in situ 8 | 1,745
juvenile dermatomyositis 8 | 1,189
primitive neuroectodermal tumor 8 | 3,031
progressive supranuclear palsy 8 | 674
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 1,563
Alzheimer's disease 7 | 644
Disease Progression 7 | 125
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
cystic fibrosis 7 | 1,670
non-small cell lung carcinoma 7 | 413
posterior fossa group A ependymoma 7 | 1,511
sonic hedgehog group medulloblastoma 7 | 1,482
Cholestasis 6 | 93
active Crohn's disease 6 | 918
gastric cancer 6 | 436
group 3 medulloblastoma 6 | 2,254
posterior fossa group B ependymoma 6 | 1,530
primary Sjogren syndrome 6 | 789
primary pancreatic ductal adenocarcinoma 6 | 1,271
IGA Glomerulonephritis 5 | 454
Mantle cell lymphoma 5 | 20
Neurodegenerative disease 5 | 383
acute myeloid leukemia 5 | 785
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
atypical teratoid/rhabdoid tumor 5 | 1,095
breast carcinoma 5 | 1,614
colon cancer 5 | 1,475
cutaneous lupus erythematosus 5 | 1,056
group 4 medulloblastoma 5 | 1,875
medulloblastoma 5 | 1,524
Adverse reaction to drug 4 | 54
Atherosclerosis 4 | 275
Atopic dermatitis 4 | 944
Down syndrome 4 | 548
Dubin-Johnson syndrome 4 | 6
Endometriosis 4 | 535
Epilepsy 4 | 346
Lipid metabolism disorder 4 | 102
Peroxisomal disease 4 | 20
Pseudoxanthoma elasticum 4 | 19
Tangier disease 4 | 8
aldosterone-producing adenoma 4 | 664
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
hepatocellular carcinoma 4 | 550
pituitary cancer 4 | 1,972
Amyotrophic Lateral Sclerosis 3 | 432
Cholecystolithiasis 3 | 8
Coronary artery disease 3 | 240
Crohn's disease 3 | 304
Diabetes Mellitus, Non-Insulin-Dependent 3 | 161
Duchenne muscular dystrophy 3 | 602
Liver carcinoma 3 | 217
Polycystic Ovary Syndrome 3 | 335
Prostatic Neoplasms 3 | 471
Vascular disease 3 | 281
mucosa-associated lymphoid tissue lymphoma 3 | 480
non diabetic and post-ischemic heart failure 3 | 200
pancreatic carcinoma 3 | 567
periodontitis 3 | 269

Tissue

Blood and immune system 105 | 17,995
Digestive Tract 105 | 18,473
Endocrine System 105 | 18,512
Female tissues 105 | 18,647
Liver and Pancreas 105 | 18,136
Male tissues 105 | 17,969
Nervous System 105 | 18,561
Urinary Tract 105 | 18,444
Cardiovascular System 104 | 17,958
Respiratory system 104 | 17,484
Skin and soft tissues 104 | 18,115

Target Family

Enzyme 42 | 4,146
Transporter 37 | 473
Non-IDG 23 | 11,969
Ion Channel 2 | 341
Kinase 1 | 634

Reactome Pathway

ABC-family proteins mediated t... 105 | 105
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
ATP-binding cassette sub-family A member 3 ABCA3 Tbio Transporter -2.22245 177.7 29
ATP-binding cassette sub-family A member 12 ABCA12 Tbio Transporter -2.02521 199.6 62
Protein OS-9 OS9 Tbio Non-IDG -1.76209 57.4 143
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.86105 71.4 158
26S protease regulatory subunit 6A PSMC3 Tbio Enzyme -1.26468 18.5 271
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.44048 25.4 280
ATP-binding cassette sub-family A member 10 ABCA10 Tdark Transporter -0.21577 2.10 22