Development Level

Tbio 85 | 11,651
Tclin 8 | 612
Tchem 6 | 1,388
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating total pr... 3 | 49
vertebral fusion 3 | 23
abnormal behavioral response t... 2 | 66
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
impaired glucose tolerance 2 | 75
increased mean corpuscular hem... 2 | 96
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating fructosa... 1 | 30
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased kidney weight 1 | 6
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
limb grasping 1 | 41
male infertility 1 | 123
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small adrenal glands 1 | 16

Disease

ovarian cancer 67 | 8,520
Carcinoma 58 | 11,493
psoriasis 47 | 6,694
osteosarcoma 43 | 7,950
lung cancer 40 | 4,740
Multiple myeloma 30 | 1,332
glioblastoma 30 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Kidney cancer 24 | 2,613
Breast cancer 23 | 3,578
Colorectal Neoplasms 22 | 243
malignant mesothelioma 22 | 3,232
medulloblastoma, large-cell 22 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
atypical teratoid / rhabdoid tumor 19 | 5,112
Cancer 18 | 2,499
ependymoma 17 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
HIV Infections 16 | 102
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
invasive ductal carcinoma 16 | 2,951
lung carcinoma 16 | 2,843
lung adenocarcinoma 14 | 2,716
non-small cell lung cancer 14 | 2,890
Waldenstrons macroglobulinemia 13 | 765
dermatomyositis 13 | 966
pancreatic cancer 13 | 2,398
Astrocytoma, Pilocytic 12 | 3,081
Autosomal recessive predisposition 12 | 1,442
Pick disease 12 | 1,894
adult high grade glioma 12 | 3,801
group 3 medulloblastoma 11 | 4,104
interstitial cystitis 11 | 2,312
Liver Cirrhosis, Experimental 10 | 769
Rheumatoid arthritis 10 | 1,191
Skin cancer 10 | 469
astrocytoma 10 | 1,146
diabetes mellitus 10 | 1,728
non primary Sjogren syndrome sicca 9 | 891
tuberculosis 9 | 2,010
Cholestasis 8 | 155
Hepatomegaly 8 | 285
ductal carcinoma in situ 8 | 1,745
oligodendroglioma 8 | 2,850
progressive supranuclear palsy 8 | 676
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 1,819
Disease Progression 7 | 136
Epilepsy 7 | 792
Failure to gain weight 7 | 365
Melanoma 7 | 711
Pediatric failure to thrive 7 | 365
astrocytic glioma 7 | 2,597
juvenile dermatomyositis 7 | 1,187
primitive neuroectodermal tumor 7 | 3,035
Alzheimer's disease 6 | 658
Anemia 6 | 365
Liver cancer 6 | 604
Seizures 6 | 596
Tangier disease 6 | 10
active Crohn's disease 6 | 922
acute quadriplegic myopathy 6 | 1,158
cystic fibrosis 6 | 1,696
primary Sjogren syndrome 6 | 735
Anteverted nostril 5 | 191
Arthritis, Rheumatoid 5 | 174
Chemical and Drug Induced Liver Injury 5 | 195
Diarrhea 5 | 253
Icterus 5 | 82
Intellectual disability 5 | 1,016
Liver disease 5 | 237
Mantle cell lymphoma 5 | 23
Neurodegenerative disease 5 | 414
Osteoporosis 5 | 363
Peripheral Neuropathy 5 | 134
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
gastric cancer 5 | 459
medulloblastoma 5 | 720
non-small cell lung carcinoma 5 | 317
pediatric high grade glioma 5 | 1,064
Atherosclerosis 4 | 291
Atopic dermatitis 4 | 952
Broad flat nasal bridge 4 | 236
Down syndrome 4 | 499
Hepatic enzyme increased 4 | 81
Lipid metabolism disorder 4 | 114
Liver Dysfunction 4 | 99
Liver enzymes abnormal 4 | 81
Liver function test increased 4 | 81
Liver function tests abnormal finding 4 | 81
Nasal bridge wide 4 | 236
Subclinical abnormal liver function tests 4 | 81
Transaminases increased 4 | 81
aldosterone-producing adenoma 4 | 665
esophageal adenocarcinoma 4 | 737

Tissue

Endocrine System 102 | 18,159
Digestive Tract 101 | 17,369
Female tissues 101 | 17,400
Nervous System 101 | 16,725
Male tissues 100 | 17,142
Urinary Tract 100 | 16,678
Blood and immune system 99 | 16,909
Liver and Pancreas 99 | 16,750
Skin and soft tissues 99 | 17,230
Respiratory system 97 | 16,393
Cardiovascular System 93 | 15,192

Target Family

Enzyme 42 | 4,145
Transporter 34 | 473
Non-IDG 25 | 12,091
Ion Channel 2 | 344

Reactome Pathway

ABC-family proteins mediated t... 103 | 103
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Erlin-2 ERLIN2 Tbio Non-IDG -1.30418 19.6 167
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Protein OS-9 OS9 Tbio Non-IDG -1.76074 57.1 170
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
26S proteasome regulatory subunit 8 PSMC5 Tbio Enzyme -1.70989 52.2 200