Development Level

Tbio 43 | 10,625
Tchem 15 | 1,890
Tclin 8 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
vertebral fusion 2 | 23
abnormal bone structure 1 | 131
abnormal hair growth 1 | 8
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
impaired glucose tolerance 1 | 52
vertebral transformation 1 | 12

Disease

ovarian cancer 47 | 8,492
Multiple myeloma 29 | 1,328
lung cancer 29 | 4,473
psoriasis 29 | 6,685
osteosarcoma 25 | 7,933
glioblastoma 23 | 5,572
HIV Infections 15 | 100
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
Waldenstrons macroglobulinemia 11 | 765
atypical teratoid / rhabdoid tumor 11 | 4,369
dermatomyositis 11 | 967
medulloblastoma, large-cell 11 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Breast cancer 10 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
lung adenocarcinoma 10 | 2,714
malignant mesothelioma 10 | 3,163
non-small cell lung cancer 10 | 2,798
astrocytoma 9 | 1,493
lung carcinoma 9 | 2,844
Cancer 8 | 2,346
diabetes mellitus 8 | 1,663
pancreatic cancer 8 | 2,300
Pick disease 7 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
non primary Sjogren syndrome sicca 7 | 840
ependymoma 6 | 2,514
interstitial cystitis 6 | 2,299
oligodendroglioma 6 | 2,849
primary pancreatic ductal adenocarcinoma 6 | 1,271
ulcerative colitis 6 | 2,087
Mantle cell lymphoma 5 | 20
Rheumatoid Arthritis 5 | 1,171
invasive ductal carcinoma 5 | 2,950
pediatric high grade glioma 5 | 2,712
pilocytic astrocytoma 5 | 3,086
primitive neuroectodermal tumor 5 | 3,031
subependymal giant cell astrocytoma 5 | 2,287
Lung disease 4 | 136
astrocytic glioma 4 | 2,241
cutaneous lupus erythematosus 4 | 1,056
juvenile dermatomyositis 4 | 1,189
medulloblastoma 4 | 1,524
primary Sjogren syndrome 4 | 789
progressive supranuclear palsy 4 | 674
Alzheimer's disease 3 | 644
Diabetes Mellitus, Non-Insulin-Dependent 3 | 161
Diaphragmatic Hernia 3 | 40
IGA Glomerulonephritis 3 | 454
Idiopathic pulmonary fibrosis 3 | 21
Neurodegenerative disease 3 | 383
Pneumonia 3 | 133
Pulmonary Fibrosis, Idiopathic 3 | 12
Pulmonary alveolar proteinosis 3 | 13
Respiratory distress syndrome in premature infants 3 | 3
Respiratory failure 3 | 30
Stevens-Johnson syndrome 3 | 91
Type 1 diabetes mellitus 3 | 104
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
adult high grade glioma 3 | 2,148
cystic fibrosis 3 | 1,670
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
interstitial lung disease 3 | 292
maturity-onset diabetes of the young 3 | 30
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
tuberculosis 3 | 1,563
Anemia 2 | 252
Animal Mammary Neoplasms 2 | 136
Carcinoma 2 | 2,147
Chronic obstructive pulmonary disease 2 | 147
Colorectal Neoplasms 2 | 217
Diabetes Mellitus, Insulin-Dependent 2 | 77
Diabetes Mellitus, Noninsulin-Dependent 2 | 31
Diabetes mellitus type 2 2 | 69
Diarrhea 2 | 155
Epilepsy 2 | 346
Hypoglycemia 2 | 81
Lung Neoplasms 2 | 171
Mammary Neoplasms, Experimental 2 | 150
Myopathy 2 | 128
Osteoporosis 2 | 259
Pancreatic agenesis 2 | 14
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Polycystic Ovary Syndrome 2 | 335
Squamous cell carcinoma of esophagus 2 | 82
Transient neonatal diabetes mellitus 2 | 14
Treatment Refractory Type 2 Diabetes Mellitus 2 | 53
Vascular disease 2 | 281
chronic kidney disease 2 | 90
facioscapulohumeral dystrophy 2 | 286
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 550
hereditary spastic paraplegia 2 | 313
periodontitis 2 | 269
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 67 | 17,995
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Liver and Pancreas 67 | 18,136
Male tissues 67 | 17,969
Nervous System 67 | 18,561
Urinary Tract 67 | 18,444
Cardiovascular System 66 | 17,958
Respiratory system 66 | 17,484
Skin and soft tissues 66 | 18,115

Target Family

Enzyme 42 | 4,146
Non-IDG 22 | 11,969
Ion Channel 2 | 341
Transporter 1 | 473

Reactome Pathway

ABC transporter disorders 67 | 67
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein OS-9 OS9 Tbio Non-IDG -1.76209 57.4 143
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.86105 71.4 158
26S protease regulatory subunit 6A PSMC3 Tbio Enzyme -1.26468 18.5 271
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.44048 25.4 280
Derlin-1 DERL1 Tbio Non-IDG -1.80653 60.4 151
Derlin-3 DERL3 Tbio Non-IDG -1.39177 4.60 50
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.59489 39.3 30
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.12830 14.8 140