Development Level

Tbio 50 | 11,651
Tclin 7 | 612
Tchem 3 | 1,388
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, complete... 6 | 979
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
increased circulating total pr... 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 45 | 8,520
Multiple myeloma 29 | 1,332
psoriasis 27 | 6,694
lung cancer 26 | 4,740
Carcinoma 23 | 11,493
osteosarcoma 23 | 7,950
glioblastoma 20 | 5,792
HIV Infections 15 | 102
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Waldenstrons macroglobulinemia 11 | 765
Breast cancer 10 | 3,578
dermatomyositis 10 | 966
ependymoma 10 | 4,679
medulloblastoma, large-cell 10 | 6,241
Cancer 9 | 2,499
astrocytoma 9 | 1,146
atypical teratoid / rhabdoid tumor 9 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
malignant mesothelioma 9 | 3,232
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
Pick disease 6 | 1,894
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
non primary Sjogren syndrome sicca 6 | 891
Astrocytoma, Pilocytic 5 | 3,081
Mantle cell lymphoma 5 | 23
adult high grade glioma 5 | 3,801
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Anemia 4 | 365
Autosomal recessive predisposition 4 | 1,442
Liver Cirrhosis, Experimental 4 | 769
Muscle Weakness 4 | 170
Osteoporosis 4 | 363
Rheumatoid arthritis 4 | 1,191
astrocytic glioma 4 | 2,597
juvenile dermatomyositis 4 | 1,187
primary Sjogren syndrome 4 | 735
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Diarrhea 3 | 253
Failure to gain weight 3 | 365
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Neurodegenerative disease 3 | 414
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Pediatric failure to thrive 3 | 365
Skeletal muscle atrophy 3 | 139
Stevens-Johnson syndrome 3 | 92
acute myeloid leukemia 3 | 783
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
esophageal adenocarcinoma 3 | 737
muscle degeneration 3 | 139
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Arthralgia 2 | 90
Arthrogryposis 2 | 54
Asthma 2 | 385
Babinski Reflex 2 | 100
Congenital pes cavus 2 | 88
Congestive heart failure 2 | 113
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Epilepsy 2 | 792
Esophageal Squamous Cell Carcinoma 2 | 77
Gait abnormality 2 | 135
Hepatomegaly 2 | 285
Hyperhidrosis disorder 2 | 81
Increased sweating 2 | 81
Loss of speech 2 | 16
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Myopathy 2 | 185
Neuropathy 2 | 261
Peripheral Neuropathy 2 | 134
Seizures 2 | 596
Spastic Paraplegia 2 | 42
Spastic gait 2 | 23
Squamous cell carcinoma of esophagus 2 | 77
Sweating 2 | 81
Vascular disease 2 | 319
active Crohn's disease 2 | 922
chronic kidney disease 2 | 90
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
medulloblastoma 2 | 720
periodontitis 2 | 293
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Endocrine System 62 | 18,159
Blood and immune system 61 | 16,909
Digestive Tract 61 | 17,369
Female tissues 61 | 17,400
Male tissues 61 | 17,142
Nervous System 61 | 16,725
Respiratory system 61 | 16,393
Urinary Tract 61 | 16,678
Liver and Pancreas 60 | 16,750
Skin and soft tissues 60 | 17,230
Cardiovascular System 59 | 15,192

Target Family

Enzyme 42 | 4,145
Non-IDG 19 | 12,091
Ion Channel 2 | 344

Reactome Pathway

ABC transporter disorders 63 | 63
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Erlin-2 ERLIN2 Tbio Non-IDG -1.30418 19.6 167
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Protein OS-9 OS9 Tbio Non-IDG -1.76074 57.1 170
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
26S proteasome regulatory subunit 8 PSMC5 Tbio Enzyme -1.70989 52.2 200
26S proteasome regulatory subunit 4 PSMC1 Tbio Enzyme -1.15617 13.5 118