Development Level

Tbio 40 | 11,178
Tchem 15 | 1,885
Tclin 7 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 6 | 979
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
increased circulating total pr... 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 30 | 8,297
Carcinoma 19 | 11,192
lung cancer 18 | 4,607
osteosarcoma 18 | 7,766
Multiple myeloma 16 | 1,296
psoriasis 16 | 6,514
glioblastoma 13 | 5,635
HIV Infections 10 | 94
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,204
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,911
astrocytoma 7 | 1,113
atypical teratoid / rhabdoid tumor 7 | 4,971
medulloblastoma, large-cell 7 | 6,086
Breast cancer 6 | 3,469
ependymoma 6 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,902
malignant mesothelioma 6 | 3,135
non-small cell lung cancer 6 | 2,799
Cancer 5 | 2,388
dermatomyositis 5 | 941
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
lung adenocarcinoma 5 | 2,627
pancreatic cancer 5 | 2,322
Pick disease 4 | 1,856
interstitial cystitis 4 | 2,237
progressive supranuclear palsy 4 | 656
ulcerative colitis 4 | 1,765
Anemia 3 | 353
Autosomal recessive predisposition 3 | 1,407
Intellectual disability 3 | 998
Kidney cancer 3 | 2,548
Muscle Weakness 3 | 168
Neurodegenerative disease 3 | 402
Stevens-Johnson syndrome 3 | 92
Waldenstrons macroglobulinemia 3 | 742
group 3 medulloblastoma 3 | 4,002
invasive ductal carcinoma 3 | 2,867
primitive neuroectodermal tumor 3 | 2,957
subependymal giant cell astrocytoma 3 | 2,230
Asthma 2 | 370
Astrocytoma, Pilocytic 2 | 3,006
Babinski Reflex 2 | 98
Congenital pes cavus 2 | 86
Diabetes Mellitus, Non-Insulin-Dependent 2 | 140
Diabetes Mellitus, Type 2 2 | 136
Diarrhea 2 | 245
Epilepsy 2 | 775
Esophageal Squamous Cell Carcinoma 2 | 72
Failure to gain weight 2 | 359
Gait abnormality 2 | 129
Gait imbalance 2 | 17
Loss of speech 2 | 16
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Myopathy 2 | 185
Neurogenic Muscular Atrophy 2 | 136
Neurogenic muscle atrophy, especially in the lower limbs 2 | 136
Neuropathy 2 | 254
Osteoporosis 2 | 348
Pediatric failure to thrive 2 | 359
Pick's disease 2 | 15
Rheumatoid arthritis 2 | 1,156
Seizures 2 | 584
Skeletal muscle atrophy 2 | 136
Spastic Paraplegia 2 | 41
Spastic gait 2 | 22
Squamous cell carcinoma of esophagus 2 | 72
Vascular disease 2 | 294
acute myeloid leukemia 2 | 760
adult high grade glioma 2 | 3,701
astrocytic glioma 2 | 2,530
cutaneous lupus erythematosus 2 | 1,016
diabetes mellitus 2 | 1,683
hereditary spastic paraplegia 2 | 313
juvenile dermatomyositis 2 | 1,147
lung carcinoma 2 | 2,755
maturity-onset diabetes of the young 2 | 32
medulloblastoma 2 | 702
muscle degeneration 2 | 136
non primary Sjogren syndrome sicca 2 | 861
periodontitis 2 | 280
tuberculosis 2 | 1,963
Abnormality of fatty-acid metabolism 1 | 6
Chronic lung disease 1 | 6
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Transient Neonatal, 1 1 | 4
Diabetes Mellitus, Type 1 1 | 43
Distal intestinal obstruction syndrome 1 | 2
Fasciculation, Tongue 1 | 7
Fatty acids abnormal 1 | 6
Hyperinsulinaemic hypoglycaemia 1 | 16
Hypoketotic hypoglycemia 1 | 11
Islets of Langerhans hyperplasia 1 | 11
Limb contractures 1 | 6
Lower limb hyperreflexia 1 | 9
Photosensitive trichothiodystrophy 1 | 30
Primary immunodeficiency disease 1 | 54
Pseudobulbar behavioral symptoms 1 | 3
Recurrent bronchopulmonary infections 1 | 2
permanent neonatal diabetes mellitus 1 | 9

Tissue

Endocrine System 62 | 18,159
Blood and immune system 61 | 16,909
Digestive Tract 61 | 17,369
Female tissues 61 | 17,400
Male tissues 61 | 17,142
Nervous System 61 | 16,725
Respiratory system 61 | 16,393
Urinary Tract 61 | 16,678
Liver and Pancreas 60 | 16,750
Skin and soft tissues 60 | 17,230
Cardiovascular System 59 | 15,192

Target Family

Enzyme 42 | 4,145
Non-IDG 19 | 12,091
Ion Channel 2 | 344

Reactome Pathway

ABC transporter disorders 63 | 63
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome subunit beta type-11 PSMB11 Tchem Enzyme -1.40386 27.2 74
26S proteasome non-ATPase regulatory subunit 2 PSMD2 Tbio Enzyme -1.60281 36.3 389
Derlin-3 DERL3 Tbio Non-IDG -1.46252 25.1 60
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Proteasome subunit beta type-8 PSMB8 Tclin Enzyme -2.43601 278.6 295
Proteasome subunit beta type-6 PSMB6 Tbio Enzyme -1.08909 10.9 98
26S proteasome non-ATPase regulatory subunit 1 PSMD1 Tchem Enzyme -1.36924 21.2 105
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143