Development Level

Tbio 6 | 11,445

IMPC Phenotype

hemorrhage 1 | 23
preweaning lethality, incomple... 1 | 499

Disease

Cancer 6 | 2,499
Carcinoma 4 | 11,493
Severe combined immunodeficiency 4 | 51
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Waldenstrons macroglobulinemia 3 | 765
atypical teratoid / rhabdoid tumor 3 | 5,112
group 3 medulloblastoma 3 | 4,104
Acute blood cancer 2 | 6
Acute leukemia 2 | 15
Adenocarcinoma of lung 2 | 142
Biparietal narrowing 2 | 28
Bird-like facies 2 | 4
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Broad flat nasal bridge 2 | 236
Chromosome Breakage 2 | 36
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Cryptorchidism 2 | 296
DNA ligase IV deficiency 2 | 7
Decreased width of the skull 2 | 28
Disease Models, Animal 2 | 155
Dull intelligence 2 | 645
Erythema 2 | 58
Fetal Growth Retardation 2 | 189
Flushing 2 | 60
Global developmental delay 2 | 608
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hypoplastic mandible condyle 2 | 275
Increased chromosomal breakage 2 | 27
Infant, Small for Gestational Age 2 | 176
Insulin Resistance 2 | 72
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Kidney cancer 2 | 2,613
LIG4 Syndrome 2 | 2
Large beaked nose 2 | 5
Low anterior hairline 2 | 30
Low intelligence 2 | 645
Lymphoma 2 | 81
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Micrognathism 2 | 275
Multiple myeloma 2 | 1,332
Nasal bridge wide 2 | 236
Pancytopenia 2 | 45
Photosensitivity of skin 2 | 51
Poor growth 2 | 114
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Short stature 2 | 531
Sloping forehead 2 | 46
Small head 2 | 374
Systemic lupus erythematosus 2 | 194
Telecanthus 2 | 62
Thin lips 2 | 49
Upward slant of palpebral fissure 2 | 75
Very poor growth 2 | 114
Werner syndrome 2 | 29
Wide skull shape 2 | 88
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
ependymoma 2 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
malignant mesothelioma 2 | 3,232
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
psoriasis 2 | 6,694
Acquired immunodeficiency syndrome 1 | 197
Broad nasal tip 1 | 28
Broad thumbs 1 | 28
Broad-based gait 1 | 19
Cortical gyral simplification 1 | 19
Dry skin 1 | 75
Enophthalmos 1 | 75
Eosinophilia 1 | 28
Hypoplastic feet 1 | 66
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Lymphadenopathy 1 | 62
Metabolic syndrome X 1 | 52
Nijmegen breakage syndrome 1 | 24
Recurrent infections 1 | 48
Seckel syndrome 1 | 34
Sunken eyes 1 | 63
Xerosis 1 | 75

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Non-IDG 3 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

2-LTR circle formation 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA ligase 4 LIG4 Tbio Enzyme -2.14909 140.9 204
PC4 and SFRS1-interacting protein PSIP1 Tbio Epigenetic -2.56190 391.2 150
DNA repair protein XRCC4 XRCC4 Tbio Non-IDG -2.38352 232.9 322
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
X-ray repair cross-complementing protein 6 XRCC6 Tbio Non-IDG -2.86424 688.3 865
High mobility group protein HMG-I/HMG-Y HMGA1 Tbio Transcription Factor -2.59141 433.8 253