Development Level

Tbio 25 | 11,445
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal kidney morphology 1 | 65
decreased IgM level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased lean body mass 1 | 135
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
long tibia 1 | 25

Disease

Carcinoma 22 | 11,493
ovarian cancer 21 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
osteosarcoma 13 | 7,950
Autosomal recessive predisposition 12 | 1,442
Multiple myeloma 11 | 1,332
psoriasis 11 | 6,694
Muscle hypotonia 10 | 571
medulloblastoma, large-cell 10 | 6,241
Acidosis, Lactic 9 | 97
Cerebellar Ataxia 9 | 304
Epilepsy 9 | 792
Intellectual disability 9 | 1,016
Dull intelligence 8 | 645
Lactic acidemia 8 | 95
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Seizures 8 | 596
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
group 3 medulloblastoma 8 | 4,104
lung cancer 8 | 4,740
Breast cancer 7 | 3,578
breast carcinoma 7 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
Chondroma 6 | 15
Hypoglycemia 6 | 152
Infantile onset 6 | 238
Leigh disease 6 | 100
Stomach Neoplasms 6 | 300
adult high grade glioma 6 | 3,801
primitive neuroectodermal tumor 6 | 3,035
Astrocytoma, Pilocytic 5 | 3,081
Cancer 5 | 2,499
D-2-hydroxyglutaric aciduria 5 | 9
Degenerative polyarthritis 5 | 115
Highly variable clinical phenotype 5 | 150
Highly variable phenotype and severity 5 | 150
Highly variable phenotype, even within families 5 | 150
Increased serum lactate 5 | 60
Kidney cancer 5 | 2,613
Lactic acidosis 5 | 51
Low Vision 5 | 174
Multiple, subcutaneous nodules 5 | 53
Nystagmus 5 | 317
Optic Atrophy 5 | 242
Osteoarthritis 5 | 184
Papilloma 5 | 44
Phenotypic variability 5 | 150
Small head 5 | 374
Subcutaneous nodule 5 | 53
Visual Impairment 5 | 174
Von Hippel-Lindau disease 5 | 19
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
Blepharoptosis 4 | 231
Cerebral atrophy 4 | 178
Deglutition Disorders 4 | 132
Dystonia 4 | 164
Dystonic disease 4 | 106
Failure to gain weight 4 | 365
Gastrointestinal Hemorrhage 4 | 52
Gastrointestinal Stromal Tumors 4 | 48
Gastrointestinal stromal tumor 4 | 62
Hemangioma 4 | 69
Hyperhidrosis disorder 4 | 81
Impaired cognition 4 | 96
Increased sweating 4 | 81
Intestinal Obstruction 4 | 31
Mental impairment 4 | 95
Obesity 4 | 678
Paraganglioma 4 | 15
Pediatric failure to thrive 4 | 365
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Pick disease 4 | 1,894
Pyruvate decarboxylase deficiency 4 | 16
Short stature 4 | 531
Sweating 4 | 81
ductal carcinoma in situ 4 | 1,745
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Adult onset 3 | 82
Constipation 3 | 181
Dyschezia 3 | 135
Liver Cirrhosis, Experimental 3 | 769
Macroglossia 3 | 65
Neonatal Hypotonia 3 | 64
Ophthalmoplegia 3 | 106
Tachycardia 3 | 43

Tissue

Blood and immune system 27 | 16,909
Cardiovascular System 27 | 15,192
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678

Target Family

Enzyme 26 | 4,145
Non-IDG 1 | 12,091

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 27 | 27
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 Tchem Enzyme -3.19944 1567.0 498
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1 Tbio Enzyme -2.31887 204.2 436
Fumarate hydratase, mitochondrial FH Tbio Enzyme -2.42296 251.7 363
Cytoplasmic aconitate hydratase ACO1 Tbio Enzyme -2.59601 396.5 350
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB Tbio Enzyme -2.68774 460.2 321
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Isocitrate dehydrogenase [NADP], mitochondrial IDH2 Tclin Enzyme -2.94039 813.3 296
Dihydrolipoyl dehydrogenase, mitochondrial DLD Tbio Enzyme -2.58834 373.1 282
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA Tbio Enzyme -2.26118 161.8 241
Citrate synthase, mitochondrial CS Tbio Enzyme -2.61735 325.4 239