Development Level

Tclin 5 | 613
Tbio 3 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal male genitalia morpho... 1 | 3
abnormal vocalization 1 | 21
absent external male genitalia 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased total body fat amoun... 1 | 134
oligodactyly 1 | 1
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
small kidney 1 | 16

Disease

Carcinoma 8 | 11,493
Congenital adrenal hyperplasia 8 | 73
Cushing's syndrome 7 | 48
Autosomal recessive predisposition 6 | 1,442
Hyperaldosteronism 6 | 35
Hypertensive disease 6 | 292
Polycystic ovary syndrome 6 | 360
Adrenal hyperplasia 5 | 13
Hyperandrogenism 5 | 34
Hypertension 5 | 396
Hypoaldosteronism 5 | 12
Increase in blood pressure 5 | 119
Mineralocorticoid insufficiency 5 | 12
Renal salt wasting 5 | 18
adrenocortical carcinoma 5 | 1,428
psoriasis 5 | 6,694
Adenoma 4 | 167
Adrenal cortical adenoma 4 | 19
Adrenocorticotropic hormone excess 4 | 5
Adrenogenital Syndrome 4 | 6
Conn's syndrome 4 | 22
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
Gynecomastia 4 | 64
Hypercortisolism 4 | 8
Hyperkalemia 4 | 17
Hypokalemia 4 | 52
Hypospadias 4 | 53
Increased circulating ACTH level 4 | 8
Low to undetectable plasma cortisol 4 | 12
Osteoporosis 4 | 363
Pediatric failure to thrive 4 | 365
Prostatic Neoplasms 4 | 495
Small testicle 4 | 75
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Absence of secondary sex characteristics 3 | 22
Adrenal Hyperplasia, Congenital 3 | 9
Blastomycosis 3 | 12
Candidiasis of mouth 3 | 5
Candidiasis of skin 3 | 6
Chromoblastomycosis 3 | 10
Coccidioidomycosis 3 | 8
Cryptorchidism 3 | 296
Decreased fertility in females 3 | 20
Decreased male fertility 3 | 7
Decreased plasma renin activity 3 | 9
Dehydration 3 | 40
Delayed Puberty 3 | 97
Disseminated candidiasis 3 | 4
Elevated follicle stimulating hormone 3 | 15
Elevated luteinizing hormone 3 | 14
Elevated plasma renin 3 | 9
Enlarged polycystic ovaries 3 | 10
Generalized hyperpigmentation 3 | 22
Histoplasmosis 3 | 13
Hyponatremia 3 | 25
Hypotension 3 | 82
Infertility 3 | 188
Male Pseudohermaphroditism 3 | 19
Neonatal onset 3 | 21
Paracoccidioidomycosis 3 | 12
Penile hypospadias 3 | 106
Pityriasis simplex 3 | 6
Pityriasis versicolor 3 | 19
Pseudohermaphroditism 3 | 16
Seborrheic dermatitis 3 | 31
Short stature 3 | 531
Tinea corporis 3 | 25
Tinea cruris 3 | 12
Tinea pedis 3 | 29
Urogenital sinus anomaly 3 | 15
Vomiting 3 | 116
Abnormal circulating renin 2 | 4
Abnormality of the menstrual cycle 2 | 4
Addison's disease 2 | 31
Advanced bone age 2 | 35
Anovulation 2 | 21
Antley-Bixler syndrome 2 | 16
Aortic root dilatation 2 | 11
Carcinoma, Hepatocellular 2 | 228
Diagnostic Test for Secondary Adrenocortical Insufficiency 2 | 4
Electrocardiogram abnormal 2 | 81
Female external genitalia in males 2 | 13
Hyperpigmentation 2 | 37
Hyperpigmented genitalia 2 | 3
Hypertrophy of clitoris 2 | 40
Hypoplasia of vagina 2 | 14
Infantile uterus 2 | 23
Insulin Resistance 2 | 72
Kidney disease 2 | 430
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Neonatal hypoglycemia 2 | 17
Paranoia 2 | 20
Paranoid Disorders 2 | 8
Penile melanosis 2 | 3
Premature adrenarche 2 | 3
Premature ovarian failure 2 | 65
Rudimentary vagina 2 | 14
menstrual abnormality 2 | 4

Tissue

Endocrine System 11 | 18,159
Digestive Tract 10 | 17,369
Male tissues 10 | 17,142
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Skin and soft tissues 9 | 17,230
Urinary Tract 8 | 16,678
Blood and immune system 7 | 16,909
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Cardiovascular System 3 | 15,192

Target Family

Enzyme 10 | 4,145
Non-IDG 1 | 12,091

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 11 | 11
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
Cytochrome P450 11B1, mitochondrial CYP11B1 Tclin Enzyme -2.66308 432.9 136
Cytochrome P450 11B2, mitochondrial CYP11B2 Tchem Non-IDG -2.82678 695.9 162
Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 Tchem Enzyme -3.04846 1171.6 189
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1 Tclin Enzyme -3.09734 1226.2 369
Steroid 21-hydroxylase CYP21A2 Tbio Enzyme 0.00000 214
Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 Tclin Enzyme -2.90022 890.0 302
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.87479 75.7 171
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 HSD3B2 Tclin Enzyme -2.06512 109.2 126
Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 Tclin Enzyme -2.93656 785.3 296