Development Level

Tbio 32 | 11,445
Tchem 13 | 1,598

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 2 | 239
increased circulating alkaline... 2 | 122
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal kidney morphology 1 | 65
absent testes 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased IgM level 1 | 1
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 36 | 11,493
ovarian cancer 29 | 8,520
osteosarcoma 23 | 7,950
Autosomal recessive predisposition 21 | 1,442
psoriasis 21 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
glioblastoma 18 | 5,792
lung cancer 18 | 4,740
Multiple myeloma 17 | 1,332
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Mental and motor retardation 15 | 608
medulloblastoma, large-cell 15 | 6,241
atypical teratoid / rhabdoid tumor 14 | 5,112
group 3 medulloblastoma 14 | 4,104
Cancer 13 | 2,499
pancreatic cancer 13 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung adenocarcinoma 12 | 2,716
Breast cancer 11 | 3,578
Cerebellar Ataxia 11 | 304
Dull intelligence 11 | 645
Intellectual disability 11 | 1,016
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
malignant mesothelioma 11 | 3,232
Acidosis, Lactic 10 | 97
Epilepsy 10 | 792
Seizures 10 | 596
Waldenstrons macroglobulinemia 10 | 765
ependymoma 10 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
non-small cell lung cancer 10 | 2,890
Carcinoma, Hepatocellular 9 | 228
Hypoglycemia 9 | 152
Lactic acidemia 9 | 95
Liver carcinoma 9 | 240
Muscle hypotonia 9 | 571
adult high grade glioma 9 | 3,801
breast carcinoma 9 | 1,638
invasive ductal carcinoma 9 | 2,951
primitive neuroectodermal tumor 9 | 3,035
Stomach Neoplasms 8 | 300
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Astrocytoma, Pilocytic 7 | 3,081
Failure to gain weight 7 | 365
Pediatric failure to thrive 7 | 365
Pick disease 7 | 1,894
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
diabetes mellitus 7 | 1,728
tuberculosis 7 | 2,010
Degenerative polyarthritis 6 | 115
Highly variable clinical phenotype 6 | 150
Highly variable phenotype and severity 6 | 150
Highly variable phenotype, even within families 6 | 150
Increased serum lactate 6 | 60
Infantile onset 6 | 238
Leigh disease 6 | 100
Obesity 6 | 678
Optic Atrophy 6 | 242
Osteoarthritis 6 | 184
Phenotypic variability 6 | 150
Von Hippel-Lindau disease 6 | 19
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
dermatomyositis 6 | 966
ductal carcinoma in situ 6 | 1,745
subependymal giant cell astrocytoma 6 | 2,287
Adenocarcinoma of lung 5 | 142
Chondroma 5 | 15
Disease Models, Animal 5 | 155
Gastrointestinal Hemorrhage 5 | 52
Impaired exercise tolerance 5 | 42
Kidney cancer 5 | 2,613
Lactic acidosis 5 | 51
Liver Cirrhosis, Experimental 5 | 769
Low Vision 5 | 174
Nystagmus 5 | 317
Osteoporosis 5 | 363
Paraganglioma 5 | 15
Persistent generalized lymphadenopathy 5 | 15
Phaeochromocytoma 5 | 20
Schizophrenia 5 | 1,160
Small head 5 | 374
Visual Impairment 5 | 174
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
ulcerative colitis 5 | 1,819
Cerebral atrophy 4 | 178
Down syndrome 4 | 499
Glycogen storage disease 4 | 39
Hepatomegaly 4 | 285
Neoplasm Invasiveness 4 | 161
aldosterone-producing adenoma 4 | 665
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Digestive Tract 45 | 17,369
Liver and Pancreas 45 | 16,750
Nervous System 45 | 16,725
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Blood and immune system 44 | 16,909
Endocrine System 44 | 18,159
Male tissues 44 | 17,142
Cardiovascular System 43 | 15,192
Female tissues 43 | 17,400
Respiratory system 43 | 16,393

Target Family

Enzyme 36 | 4,145
Kinase 5 | 634
Transporter 3 | 473
Non-IDG 1 | 12,091

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.56683 355.7 211
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Glutaminase liver isoform, mitochondrial GLS2 Tbio Enzyme -3.14287 1343.1 167
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.73791 419.9 129
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.46059 294.2 236
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.64656 428.3 291