Development Level

Tchem 9 | 1,598
Tbio 4 | 11,445
Tclin 4 | 613

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
preweaning lethality, complete... 2 | 979
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased circulating choleste... 1 | 93
decreased erythrocyte cell num... 1 | 62
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Cancer 12 | 2,499
ovarian cancer 10 | 8,520
Carcinoma 9 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung cancer 7 | 4,740
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Colorectal Neoplasms 5 | 243
Prostatic Neoplasms 5 | 495
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
psoriasis 5 | 6,694
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Adverse reaction to drug 4 | 61
Bipolar Disorder 4 | 666
Carcinoma, squamous cell of head and neck 4 | 31
Drug-Related Side Effects and Adverse Reactions 4 | 62
Epilepsy 4 | 792
Gout 4 | 106
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Squamous cell carcinoma of the head and neck 4 | 29
active Crohn's disease 4 | 922
group 3 medulloblastoma 4 | 4,104
pancreatic cancer 4 | 2,398
Alcoholic Intoxication, Chronic 3 | 289
Arthritis, Rheumatoid 3 | 174
Chemical and Drug Induced Liver Injury 3 | 195
Diabetes mellitus type 2 3 | 69
Endometriosis 3 | 540
Heart Diseases 3 | 43
Hypertension 3 | 396
Hypertensive disease 3 | 292
Hyperuricemia 3 | 49
Leigh disease 3 | 100
Mitochondrial Complex 1 Deficiency 3 | 28
Mitochondrial complex I deficiency 3 | 46
Multiple myeloma 3 | 1,332
NADH:Q(1) Oxidoreductase deficiency 3 | 24
Neoplasms 3 | 63
Nervous System Diseases 3 | 53
Obesity 3 | 678
Seizures 3 | 596
Treatment Refractory Type 2 Diabetes Mellitus 3 | 53
Vomiting 3 | 116
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
interstitial cystitis 3 | 2,312
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
nervous system disorder 3 | 53
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Acidosis, Lactic 2 | 97
Atrophy of cerebellum 2 | 103
Babinski Reflex 2 | 100
Bladder Neoplasm 2 | 112
Blepharoptosis 2 | 231
Blind Vision 2 | 111
Blindness, Legal 2 | 110
Cerebellar degeneration 2 | 103
Decreased tendon reflex 2 | 122
Developmental regression 2 | 95
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperreflexia 2 | 209
Infratentorial atrophy 2 | 103
Lactic acidemia 2 | 95
Loss of developmental milestones 2 | 95
Mental deterioration in childhood 2 | 95
Neurodevelopmental regression 2 | 95
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Phenotypic variability 2 | 150
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Skeletal muscle atrophy 2 | 139
Urinary Bladder Neoplasms 2 | 114
muscle degeneration 2 | 139

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Nervous System 15 | 16,725
Cardiovascular System 14 | 15,192

Target Family

Enzyme 11 | 4,145
Transporter 5 | 473
Non-IDG 1 | 12,091

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 17 | 17
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Multidrug resistance-associated protein 1 ABCC1 Tchem Transporter -2.81072 662.2 328
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.41877 2731.1 246
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.12097 1326.4 550
RalA-binding protein 1 RALBP1 Tbio Non-IDG -1.99667 110.8 320
Multidrug resistance protein 1 ABCB1 Tchem Transporter -3.61827 4039.4 875
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 Tclin Enzyme -2.50595 294.5 172
Xanthine dehydrogenase/oxidase XDH Tclin Enzyme -2.69810 506.6 179
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 Tclin Enzyme -2.71218 475.2 197