Development Level

Tbio 7 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
cataract 2 | 92
embryonic lethality prior to o... 2 | 239
abnormal allantois morphology 1 | 8
abnormal coat appearance 1 | 31
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 9 | 11,493
psoriasis 6 | 6,694
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Arthritis, Rheumatoid 4 | 174
Colorectal Neoplasms 4 | 243
Liver Cirrhosis, Experimental 4 | 769
group 3 medulloblastoma 4 | 4,104
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
Alcoholic Intoxication, Chronic 3 | 289
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Chemical and Drug Induced Liver Injury 3 | 195
Cleft Lip 3 | 141
Cleft Palate 3 | 271
Hyperhomocysteinemia 3 | 37
Kidney cancer 3 | 2,613
astrocytic glioma 3 | 2,597
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
neural tube defect 3 | 9
primitive neuroectodermal tumor 3 | 3,035
Acute lymphoid leukemia 2 | 25
Adverse reaction to drug 2 | 61
Alzheimer's disease 2 | 658
Anemia 2 | 365
Anemia, Megaloblastic 2 | 16
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Breast cancer 2 | 3,578
Burkitt's lymphoma 2 | 15
Carcinoma of female breast 2 | 20
Cognitive delay 2 | 608
Congenital heart disease 2 | 93
Drug-Related Side Effects and Adverse Reactions 2 | 62
Endometriosis 2 | 540
Female infertility 2 | 30
Gestational trophoblastic neoplasia 2 | 14
Global developmental delay 2 | 608
Homocystinuria 2 | 21
Infertility, Female 2 | 28
Juvenile rheumatoid arthritis 2 | 111
Lymphoma, Non-Hodgkin 2 | 24
Malignant mesothelioma of pleura 2 | 7
Malignant tumor of head and/or neck 2 | 15
Malignant tumor of lung 2 | 5
Mammary Neoplasms 2 | 425
Megaloblastic anemia 2 | 18
Meningeal Leukemia 2 | 7
Mental and motor retardation 2 | 608
Mycosis fungoides 2 | 29
Neoplasm Metastasis 2 | 168
Nervous System Diseases 2 | 53
Neural Tube Defects 2 | 31
Neural tube defect, folate-sensitive 2 | 4
Non-Hodgkin's lymphoma 2 | 22
Osteosarcoma of bone 2 | 6
Pancytopenia 2 | 45
Polycystic ovary syndrome 2 | 360
Precursor Cell Lymphoblastic Leukemia Lymphoma 2 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 | 49
Schizophrenia 2 | 1,160
Thrombocytopenia 2 | 197
Urinary Bladder Neoplasms 2 | 114
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
nasopharyngeal carcinoma 2 | 1,058
nervous system disorder 2 | 53
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Arsenic Poisoning 1 | 62
Cervical Intraepithelial Neoplasia 1 | 2
Depression, Postpartum 1 | 7
Inflammatory disease of mucous membrane 1 | 8
Microvascular Angina 1 | 1
Muscle Weakness 1 | 170
Vascular Diseases 1 | 16
Venous Thrombosis 1 | 47

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Respiratory system 11 | 16,393

Target Family

Enzyme 11 | 4,145
Transporter 1 | 473

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 12 | 12
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Methionyl-tRNA formyltransferase, mitochondrial MTFMT Tbio Enzyme -2.42792 264.8 69
Folylpolyglutamate synthase, mitochondrial FPGS Tchem Enzyme -1.90018 79.8 131
5-formyltetrahydrofolate cyclo-ligase MTHFS Tbio Enzyme -1.10094 12.8 167
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.43089 24.9 131
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.66972 40.2 102