Development Level

Tbio 12 | 11,445
Tchem 6 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased leukocyte cell numbe... 2 | 73
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal lung morphology 1 | 26
abnormal vocalization 1 | 21
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 15 | 11,493
medulloblastoma, large-cell 12 | 6,241
Autosomal recessive predisposition 11 | 1,442
Dull intelligence 11 | 645
Intellectual disability 11 | 1,016
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
glioblastoma 9 | 5,792
group 3 medulloblastoma 9 | 4,104
osteosarcoma 9 | 7,950
ovarian cancer 9 | 8,520
psoriasis 9 | 6,694
Seizures 8 | 596
primitive neuroectodermal tumor 8 | 3,035
Epilepsy 7 | 792
Hyperammonemia 7 | 30
adult high grade glioma 7 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Argininosuccinic aciduria 6 | 17
Failure to gain weight 6 | 365
Liver Cirrhosis, Experimental 6 | 769
Pediatric failure to thrive 6 | 365
atypical teratoid / rhabdoid tumor 6 | 5,112
lung cancer 6 | 4,740
Breast cancer 5 | 3,578
Citrullinemia 5 | 14
Comatose 5 | 56
Irritation - emotion 5 | 68
Lethargy 5 | 77
Protein avoidance 5 | 5
Vomiting 5 | 116
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung adenocarcinoma 5 | 2,716
Alkalosis, Respiratory 4 | 5
Brain Edema 4 | 50
Cancer 4 | 2,499
Cerebellar Ataxia 4 | 304
Cerebral Edema 4 | 30
Episodic ammonia intoxication 4 | 4
Hyperargininemia 4 | 8
Kidney cancer 4 | 2,613
Orotic aciduria 4 | 18
Schizophrenia 4 | 1,160
interstitial cystitis 4 | 2,312
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
AGAT deficiency 3 | 6
Abnormal urinary amino-acid findings 3 | 38
Amino Acid Metabolism, Inborn Errors 3 | 13
Aminoaciduria 3 | 38
Arginine deficiency 3 | 3
Astrocytoma, Pilocytic 3 | 3,081
Duchenne muscular dystrophy 3 | 601
Electroencephalogram abnormal 3 | 101
Hepatomegaly 3 | 285
High plasma glutamine 3 | 3
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hypoargininemia 3 | 3
Kidney disease 3 | 430
Muscle hypotonia 3 | 571
Nerve Degeneration 3 | 121
Ornithine carbamoyltransferase deficiency 3 | 12
Ornithine translocase deficiency 3 | 7
Phenotypic variability 3 | 150
Precancerous Conditions 3 | 80
active ulcerative colitis 3 | 764
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
fibroadenoma 3 | 559
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
Atopic dermatitis 2 | 952
Bipolar Disorder 2 | 666
Cerebrovascular disease 2 | 238
Depressive disorder 2 | 409
Down syndrome 2 | 499
Language Delay 2 | 112
Pick disease 2 | 1,894
Primary hyperoxaluria 2 | 15
Speech impairment 2 | 112
Status Epilepticus 2 | 98
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
non-small cell lung cancer 2 | 2,890

Tissue

Blood and immune system 20 | 16,909
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Male tissues 18 | 17,142
Cardiovascular System 17 | 15,192

Target Family

Enzyme 18 | 4,145
Kinase 1 | 634
Transporter 1 | 473

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 20 | 20
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Argininosuccinate lyase ASL Tbio Enzyme -2.13476 130.8 199
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.34742 219.1 219
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 Tbio Enzyme -1.74725 52.8 197
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148
Carbamoyl-phosphate synthase [ammonia], mitochondrial CPS1 Tclin Enzyme -2.28267 188.9 238
Nitric oxide synthase, brain NOS1 Tchem Enzyme -3.27741 1885.8 661
Ornithine aminotransferase, mitochondrial OAT Tchem Enzyme -2.87569 729.0 148
Bifunctional glutamate/proline--tRNA ligase EPRS Tchem Enzyme -3.11686 1267.4 98
Mitochondrial ornithine transporter 1 SLC25A15 Tbio Transporter -2.21589 161.5 45
Creatine kinase B-type CKB Tbio Kinase -2.09121 122.4 465