Development Level

Tchem 23 | 1,598
Tbio 11 | 11,445
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal bone structure 3 | 187
increased circulating alkaline... 3 | 122
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased circulating sodium l... 2 | 22
decreased total body fat amoun... 2 | 207
increased bone mineral content 2 | 108
increased circulating free fat... 2 | 20
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
short tibia 1 | 97

Disease

Carcinoma 27 | 11,493
ovarian cancer 27 | 8,520
Cancer 25 | 2,499
glioblastoma 24 | 5,792
medulloblastoma, large-cell 23 | 6,241
atypical teratoid / rhabdoid tumor 22 | 5,112
osteosarcoma 21 | 7,950
psoriasis 19 | 6,694
adult high grade glioma 18 | 3,801
ependymoma 14 | 4,679
lung cancer 14 | 4,740
Astrocytoma, Pilocytic 12 | 3,081
Breast cancer 11 | 3,578
Kidney cancer 11 | 2,613
Schizophrenia 11 | 1,160
astrocytic glioma 11 | 2,597
group 3 medulloblastoma 11 | 4,104
tuberculosis 11 | 2,010
oligodendroglioma 10 | 2,850
primitive neuroectodermal tumor 10 | 3,035
subependymal giant cell astrocytoma 10 | 2,287
Asthma 9 | 385
Breast Neoplasms 9 | 445
Intellectual disability 9 | 1,016
Mammary Neoplasms 9 | 425
malignant mesothelioma 9 | 3,232
pancreatic cancer 9 | 2,398
Obesity 8 | 678
Parkinson's disease 8 | 392
Pick disease 8 | 1,894
diabetes mellitus 8 | 1,728
non-small cell lung cancer 8 | 2,890
Lung Neoplasms 7 | 232
Multiple myeloma 7 | 1,332
Vascular disease 7 | 319
astrocytoma 7 | 1,146
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
Arthritis 6 | 290
Byzanthine arch palate 6 | 194
Cognitive delay 6 | 608
Dull intelligence 6 | 645
Global developmental delay 6 | 608
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
Stomach Neoplasms 6 | 300
juvenile dermatomyositis 6 | 1,187
Acquired scoliosis 5 | 281
Adenoma 5 | 167
Big calvaria 5 | 147
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Carcinoma, Hepatocellular 5 | 228
Concave bridge of nose 5 | 195
Curvature of spine 5 | 282
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Depressive disorder 5 | 409
Downward slant of palpebral fissure 5 | 158
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Frontal bossing 5 | 157
Hemangioma, Cavernous 5 | 20
Hyperglycemia 5 | 137
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Inflammatory bowel disease 5 | 151
Liver cancer 5 | 604
Liver carcinoma 5 | 240
Muscle hypotonia 5 | 571
Orbital separation excessive 5 | 244
Pediatric failure to thrive 5 | 365
Rheumatoid arthritis 5 | 1,191
Short stature 5 | 531
Splenomegaly 5 | 190
Toxic encephalopathy 5 | 141
cystic fibrosis 5 | 1,696
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
Alzheimer's disease 4 | 658
Brain Ischemia 4 | 110
Congenital Epicanthus 4 | 177
Heart disease 4 | 306
Kidney disease 4 | 430
Lung disease 4 | 142
Pectus excavatum 4 | 100
Seizures 4 | 596
Strabismus 4 | 270
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074

Tissue

Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393

Target Family

Kinase 18 | 634
Non-IDG 9 | 12,091
Transcription Factor 6 | 1,400
Enzyme 4 | 4,145
GPCR 1 | 408

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060