Development Level

Tbio 21 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
edema 1 | 59
hypoactivity 1 | 132
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 29
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
thin ventricular wall 1 | 24

Disease

pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Carcinoma 15 | 11,493
psoriasis 13 | 6,694
Autosomal recessive predisposition 11 | 1,442
pancreatic cancer 11 | 2,398
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
lung cancer 9 | 4,740
non-small cell lung cancer 9 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
medulloblastoma, large-cell 8 | 6,241
Epilepsy 7 | 792
Intellectual disability 7 | 1,016
Seizures 7 | 596
atypical teratoid / rhabdoid tumor 7 | 5,112
group 3 medulloblastoma 7 | 4,104
Breast cancer 6 | 3,578
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
pituitary cancer 6 | 1,972
Cancer 5 | 2,499
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
adrenocortical carcinoma 5 | 1,428
lung adenocarcinoma 5 | 2,716
malignant mesothelioma 5 | 3,232
Glycine encephalopathy 4 | 29
Liver Cirrhosis, Experimental 4 | 769
Schizophrenia 4 | 1,160
adult high grade glioma 4 | 3,801
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
pediatric high grade glioma 4 | 1,064
Adenocarcinoma of lung 3 | 142
Agenesis of corpus callosum 3 | 83
Alcohol dependence 3 | 107
Astrocytoma, Pilocytic 3 | 3,081
Carcinoma, Non-Small-Cell Lung 3 | 107
Cleft Palate 3 | 271
Disease Models, Animal 3 | 155
Encephalopathies 3 | 43
Fetal Growth Retardation 3 | 189
Hyperreflexia 3 | 209
Infant, Small for Gestational Age 3 | 176
Infantile onset 3 | 238
Intrauterine retardation 3 | 176
Kidney disease 3 | 430
Lethargy 3 | 77
Muscle Hypertonia 3 | 88
Muscle hypotonia 3 | 571
Myoclonus 3 | 74
Serine deficiency 3 | 9
Small head 3 | 374
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
nephrosclerosis 3 | 333
non-small cell lung carcinoma 3 | 317
pancreatic carcinoma 3 | 562
primary pancreatic ductal adenocarcinoma 3 | 1,109
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Atopic dermatitis 2 | 952
Bipolar Disorder 2 | 666
Curvature of spine 2 | 282
Delayed speech and language development 2 | 112
Down syndrome 2 | 499
Language Delay 2 | 112
Liver neoplasms 2 | 130
Neuropathy 2 | 261
Physical aggression 2 | 76
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Speech Delay 2 | 112
Speech impairment 2 | 112
astrocytoma 2 | 1,146
atypical teratoid/rhabdoid tumor 2 | 357
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
fibroadenoma 2 | 559
juvenile dermatomyositis 2 | 1,187
spina bifida 2 | 1,074
substance-related disorder 2 | 162

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Endocrine System 22 | 18,159
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Cardiovascular System 21 | 15,192

Target Family

Enzyme 22 | 4,145
Kinase 1 | 634

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 23 | 23
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sarcosine dehydrogenase, mitochondrial SARDH Tbio Enzyme -1.78290 56.5 35
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Glycine N-methyltransferase GNMT Tbio Enzyme -1.56517 40.8 216
Dimethylglycine dehydrogenase, mitochondrial DMGDH Tbio Enzyme -1.39556 25.3 115
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.34742 219.1 219
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.79392 65.7 131
Glycerate kinase GLYCTK Tbio Kinase -1.31760 20.4 192
Serine--pyruvate aminotransferase AGXT Tbio Enzyme -2.67998 477.5 182