Development Level

Tchem 10 | 1,388
Tbio 9 | 11,651
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 3 | 220
abnormal behavior 2 | 298
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
microphthalmia 2 | 26
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
anophthalmia 1 | 33
cataract 1 | 92
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased total body fat amoun... 1 | 134
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 14 | 8,520
osteosarcoma 11 | 7,950
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
psoriasis 10 | 6,694
Carcinoma 9 | 11,493
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
active Crohn's disease 8 | 922
medulloblastoma, large-cell 8 | 6,241
Pick disease 7 | 1,894
lung cancer 7 | 4,740
Antley-Bixler syndrome 6 | 16
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
ductal carcinoma in situ 6 | 1,745
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Cataract 5 | 297
Failure to gain weight 5 | 365
Pediatric failure to thrive 5 | 365
Smith-Lemli-Opitz syndrome 5 | 9
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
Cancer 4 | 2,499
Chondrodysplasia punctata 4 | 41
Congenital ichthyosiform erythroderma 4 | 28
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Mevalonic aciduria 4 | 16
Muscle hypotonia 4 | 571
Porokeratosis of Mibelli 4 | 4
Seizures 4 | 596
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
glioblastoma 4 | 5,792
invasive ductal carcinoma 4 | 2,951
pituitary cancer 4 | 1,972
Byzanthine arch palate 3 | 194
Carcinoma, Hepatocellular 3 | 228
Chagas disease 3 | 39
Congenital Epicanthus 3 | 177
Disseminated superficial actinic porokeratosis 3 | 4
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Hepatomegaly 3 | 285
Hyperkeratosis 3 | 50
Lens Opacities 3 | 231
Liver carcinoma 3 | 240
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Nystagmus 3 | 317
Poor school performance 3 | 645
Porokeratosis, Disseminated Superficial Actinic 3 | 4
Q fever 3 | 15
Small head 3 | 374
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
chronic rhinosinusitis 3 | 512
group 4 medulloblastoma 3 | 1,855
lung adenocarcinoma 3 | 2,716
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Acquired scoliosis 2 | 281
Anteverted nostril 2 | 191
Astrocytoma, Pilocytic 2 | 3,081
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Coronary artery disease 2 | 268
Curvature of spine 2 | 282
Diarrhea 2 | 253
Glaucoma 2 | 239
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hypercholesterolemia 2 | 44
Phenotypic variability 2 | 150
Posteriorly rotated ear 2 | 61
Short nose 2 | 132
Small nose 2 | 132
Strabismus 2 | 270
Tinea pedis 2 | 29
Vomiting 2 | 116
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Enzyme 20 | 4,145
Kinase 1 | 634

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 21 | 21
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tbio Enzyme -1.60998 38.3 124
Acetyl-CoA acetyltransferase, cytosolic ACAT2 Tbio Enzyme -1.75917 52.6 283
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.94323 876.8 272
Geranylgeranyl pyrophosphate synthase GGPS1 Tchem Enzyme -2.30083 190.0 301
Squalene synthase FDFT1 Tchem Enzyme -2.57966 374.3 291
Sterol O-acyltransferase 1 SOAT1 Tchem Enzyme -2.14394 138.3 129
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase EBP Tchem Enzyme -2.03266 104.2 137
Lanosterol 14-alpha demethylase CYP51A1 Tchem Enzyme -2.75707 588.4 158
Delta(24)-sterol reductase DHCR24 Tbio Enzyme -2.21293 167.3 181
Lanosterol synthase LSS Tchem Enzyme -2.22381 150.1 87