Development Level

Tbio 17 | 11,445
Tchem 7 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 2 | 239
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal joint morphology 1 | 23
brachydactyly 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased leukocyte cell numbe... 1 | 73
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased heart rate variabili... 1 | 7
increased prepulse inhibition 1 | 32
syndactyly 1 | 23

Disease

ovarian cancer 13 | 8,520
Carcinoma 12 | 11,493
osteosarcoma 11 | 7,950
psoriasis 11 | 6,694
invasive ductal carcinoma 8 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
medulloblastoma, large-cell 7 | 6,241
ductal carcinoma in situ 6 | 1,745
group 4 medulloblastoma 6 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
Pick disease 4 | 1,894
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
non-small cell lung cancer 4 | 2,890
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Rheumatoid arthritis 3 | 1,191
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,312
lung adenocarcinoma 3 | 2,716
non primary Sjogren syndrome sicca 3 | 891
oligodendroglioma 3 | 2,850
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Amnestic disorder 2 | 35
Amyotrophic lateral sclerosis 2 | 451
Cancer 2 | 2,499
Chemical and Drug Induced Liver Injury 2 | 195
Diabetes Mellitus, Experimental 2 | 108
Multiple myeloma 2 | 1,332
Schizophrenia 2 | 1,160
Sengers syndrome 2 | 18
Short stature 2 | 531
Spinal Dysraphism 2 | 12
Toxic encephalopathy 2 | 141
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
group 3 medulloblastoma 2 | 4,104
pancreatic cancer 2 | 2,398
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
Abnormal color vision 1 | 31
Amyotrophic lateral sclerosis type 1 1 | 23
Angle Closure Glaucoma 1 | 7
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Anteriorly placed anus 1 | 7
Apneic episodes precipitated by illness, fatigue, stress 1 | 3
Bone Diseases, Metabolic 1 | 14
Centronuclear myopathy 1 | 27
Choanal Atresia 1 | 42
Choanal stenosis 1 | 11
Cholera 1 | 34
Color vision defect 1 | 33
Color vision defect, severe 1 | 31
Cone/cone-rod dystrophy 1 | 20
Congenital Myasthenic Syndromes, Presynaptic 1 | 8
Congenital myasthenic syndrome with episodic apnea 1 | 1
Cutis marmorata 1 | 32
Decreased miniature endplate potentials (MEPP) 1 | 3
EMG: decrement at repetitive stimulation 1 | 4
EMG: decremental response of compound muscle action potential to repetitive nerve stimulation 1 | 4
Enamel erosion 1 | 19
Familial infantile myasthenia 1 | 1
Flexion contracture - elbow 1 | 32
Generalized hypotonia due to defect at the neuromuscular junction 1 | 2
Glaucoma, Angle-Closure 1 | 7
Hip joint varus deformity - observation 1 | 24
Hypophosphatasia 1 | 10
Lipodystrophy 1 | 40
Loss of peripheral vision 1 | 5
Malocclusion 1 | 57
Myasthenias 1 | 8
Ophthalmoparesis 1 | 11
Platyspondyly 1 | 56
Poor suck 1 | 17
Postnatal growth retardation 1 | 57
Relative macrocephaly 1 | 12
Respiratory insufficiency due to muscle weakness 1 | 37
Sleeping sickness 1 | 37
Sudden episodic apnea 1 | 2
Tunnel visual field constriction 1 | 5
Type 2 fiber atrophy 1 | 8
Weak cry 1 | 17
Wernicke-Korsakoff syndrome 1 | 10
cone-rod dystrophy 1 | 59

Tissue

Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678

Target Family

Enzyme 23 | 4,145
Kinase 2 | 634

PathwayCommons: smpdb Pathway

http://identifiers.org/smpdb/S... 25 | 25
http://identifiers.org/smpdb/S... 78 | 78
http://identifiers.org/smpdb/S... 60 | 60
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 59 | 59
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 58 | 58
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 47 | 47
http://identifiers.org/smpdb/S... 45 | 45
http://identifiers.org/smpdb/S... 38 | 38
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 37 | 37
http://identifiers.org/smpdb/S... 36 | 36
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 35 | 35
http://identifiers.org/smpdb/S... 34 | 34
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 33 | 33
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32
http://identifiers.org/smpdb/S... 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.87118 6.24 100
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 PTPMT1 Tbio Enzyme -1.36243 23.0 109
Choline-phosphate cytidylyltransferase A PCYT1A Tbio Enzyme -2.39713 242.7 191
Phosphatidylserine synthase 2 PTDSS2 Tbio Enzyme -0.81845 6.34 84
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 123
Phosphatidylserine synthase 1 PTDSS1 Tbio Enzyme -1.93971 87.1 109
Group XV phospholipase A2 PLA2G15 Tbio Enzyme -1.68759 48.7 88
Phosphatidylethanolamine N-methyltransferase PEMT Tbio Enzyme -1.90213 89.9 149