Development Level

Tchem 8 | 1,890
Tbio 7 | 10,625
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal lens morphology 1 | 73
abnormal response to tactile s... 1 | 16
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating alkaline... 1 | 119
increased erythrocyte cell num... 1 | 26
increased red blood cell distr... 1 | 21

Disease

psoriasis 12 | 6,685
invasive ductal carcinoma 8 | 2,950
ovarian cancer 8 | 8,491
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
lung cancer 7 | 4,473
lung carcinoma 7 | 2,844
ulcerative colitis 7 | 2,087
cutaneous lupus erythematosus 6 | 1,056
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,299
osteosarcoma 6 | 7,933
pituitary cancer 6 | 1,972
breast carcinoma 5 | 1,614
glioblastoma 5 | 5,572
non-small cell lung cancer 5 | 2,798
Cancer 4 | 2,346
Pellagra 4 | 25
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
lung adenocarcinoma 4 | 2,714
medulloblastoma, large-cell 4 | 6,234
primary Sjogren syndrome 4 | 788
Autistic Disorder 3 | 320
Mammary Neoplasms 3 | 410
Parkinson's disease 3 | 364
Schizophrenia 3 | 503
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
malignant mesothelioma 3 | 3,163
tuberculosis 3 | 1,563
Alcohol dependence 2 | 107
Asthma 2 | 349
Atopic dermatitis 2 | 944
Autoimmune polyendocrine syndrome 2 | 6
Breast cancer 2 | 3,098
Chordoid glioma 2 | 4
Dermatitis, Allergic Contact 2 | 66
Diabetes Mellitus, Experimental 2 | 106
Endometriosis 2 | 535
Huntington's disease 2 | 72
Hypertensive disease 2 | 193
Inflammation 2 | 109
Kidney disease 2 | 397
Major Depressive Disorder 2 | 106
Male infertility 2 | 170
Neurodegenerative Disorders 2 | 37
Obesity 2 | 616
Precancerous Conditions 2 | 69
Waldenstrons macroglobulinemia 2 | 764
aldosterone-producing adenoma 2 | 664
cystic fibrosis 2 | 1,670
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 557
gastric carcinoma 2 | 832
group 3 medulloblastoma 2 | 2,254
head and neck cancer 2 | 270
inflammatory breast cancer 2 | 404
juvenile dermatomyositis 2 | 1,189
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329
oligodendroglioma 2 | 2,849
pancreatic cancer 2 | 2,300
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
primitive neuroectodermal tumor 2 | 3,031
sarcoidosis 2 | 368
substance-related disorder 2 | 104
tuberculosis and treatment for 3 months 2 | 327
Alcoholic Intoxication, Chronic 1 | 41
Alcoholism 1 | 14
Amyotrophic neuralgia 1 | 13
Arthritis, Experimental 1 | 39
Cardiomegaly 1 | 66
Cholera 1 | 33
Chronic Obstructive Airway Disease 1 | 47
Constipation 1 | 43
Diarrhea 1 | 155
Diffuse large B-cell lymphoma 1 | 42
Edema 1 | 38
Gastrointestinal system disease 1 | 50
Gilles de la Tourette syndrome 1 | 47
Hyperglycemia 1 | 120
Hypotension 1 | 53
Idiopathic scoliosis 1 | 29
Intracranial aneurysm 1 | 20
Keratosis 1 | 34
Kidney Calculi 1 | 7
Lymphoid leukemia 1 | 69
MYELODYSPLASTIC SYNDROME 1 | 39
Myocardial Infarction 1 | 126
Neoplasm Invasiveness 1 | 127
Neoplastic Cell Transformation 1 | 81
Pheochromocytoma 1 | 22
Postencephalitic parkinsonism 1 | 12
Pulmonary hypertension 1 | 52
Sudden infant death syndrome 1 | 34

Tissue

Blood and immune system 18 | 17,994
Cardiovascular System 18 | 17,957
Digestive Tract 18 | 18,472
Endocrine System 18 | 18,511
Female tissues 18 | 18,646
Liver and Pancreas 18 | 18,135
Male tissues 18 | 17,968
Nervous System 18 | 18,560
Respiratory system 18 | 17,483
Skin and soft tissues 18 | 18,114
Urinary Tract 18 | 18,443

Target Family

Enzyme 17 | 4,146
Non-IDG 1 | 11,969

PathwayCommons: smpdb Pathway

Tryptophan Metabolism 18 | 18
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial AADAT Tchem Enzyme -2.20717 145.6 178
Catalase CAT Tchem Enzyme -3.60189 3190.7 575
Tryptophan 2,3-dioxygenase TDO2 Tchem Enzyme -2.88628 106.2 130
Kynurenine formamidase AFMID Tbio Enzyme -1.65079 42.7 56
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.71095 974.3 154
Indoleamine 2,3-dioxygenase 1 IDO1 Tchem Enzyme -2.52029 330.1 543
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.08451 104.9 101
Acetylserotonin O-methyltransferase ASMT Tbio Enzyme -2.38905 249.9 102
Aldehyde dehydrogenase, mitochondrial ALDH2 Tclin Enzyme -2.94988 942.0 411