Development Level

Tbio 13 | 10,625
Tchem 9 | 1,890

IMPC Phenotype

cardiovascular system phenotyp... 1 | 35
decreased body weight 1 | 174
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased total body fat amoun... 1 | 186
preweaning lethality, complete... 1 | 633

Disease

ovarian cancer 14 | 8,491
lung cancer 11 | 4,473
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
lung adenocarcinoma 8 | 2,714
psoriasis 8 | 6,685
Multiple myeloma 7 | 1,327
diabetes mellitus 7 | 1,663
pancreatic cancer 7 | 2,300
Cancer 6 | 2,346
Glycogen storage disease 6 | 37
non-small cell lung cancer 6 | 2,798
osteosarcoma 6 | 7,933
Breast cancer 5 | 3,098
Liver carcinoma 5 | 217
glioblastoma 5 | 5,572
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
malignant mesothelioma 5 | 3,163
medulloblastoma, large-cell 5 | 6,234
Congenital hemolytic anemia 4 | 31
Mammary Neoplasms 4 | 410
Mouth Neoplasms 4 | 44
Obesity 4 | 616
Osteoporosis 4 | 259
Squamous cell carcinoma 4 | 96
Waldenstrons macroglobulinemia 4 | 764
adrenocortical carcinoma 4 | 1,427
astrocytic glioma 4 | 2,241
breast carcinoma 4 | 1,614
ductal carcinoma in situ 4 | 1,745
invasive ductal carcinoma 4 | 2,950
lung carcinoma 4 | 2,844
nephrosclerosis 4 | 329
Animal Mammary Neoplasms 3 | 135
Hemolytic anemia 3 | 70
Hyperglycemia 3 | 120
Hypoglycemia 3 | 81
Lactic acidosis 3 | 43
Liver Cirrhosis, Experimental 3 | 108
Mammary Neoplasms, Experimental 3 | 149
Myocardial Ischemia 3 | 169
Pick disease 3 | 1,893
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
atypical teratoid/rhabdoid tumor 3 | 1,095
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
primary pancreatic ductal adenocarcinoma 3 | 1,271
Acute coronary syndrome 2 | 37
Adenocarcinoma 2 | 115
Adenocarcinoma of lung (disorder) 2 | 48
Alzheimer's disease 2 | 644
Anemia, Hemolytic 2 | 12
Atopic dermatitis 2 | 944
Degenerative polyarthritis 2 | 93
Diabetes Mellitus, Experimental 2 | 106
Duchenne muscular dystrophy 2 | 602
Esophageal Neoplasms 2 | 67
Glucose-6-phosphate transport defect 2 | 2
Hyperinsulinism 2 | 63
Metabolic syndrome X 2 | 155
Myoglobinuria 2 | 11
Neoplasm Invasiveness 2 | 127
acute quadriplegic myopathy 2 | 1,157
atypical teratoid / rhabdoid tumor 2 | 4,369
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cystic fibrosis 2 | 1,670
fructose-1,6-bisphosphatase deficiency 2 | 8
group 3 medulloblastoma 2 | 2,254
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
juvenile dermatomyositis 2 | 1,189
non-small cell lung carcinoma 2 | 413
oligodendroglioma 2 | 2,849
pediatric high grade glioma 2 | 2,712
posterior fossa group A ependymoma 2 | 1,511
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 3 months 2 | 327
ulcerative colitis 2 | 2,087
Acute contagious conjunctivitis 1 | 4
Asperger syndrome 1 | 35
Breast leiomyosarcoma 1 | 1
Burkitt Lymphoma 1 | 19
Candidiasis 1 | 48
Dental caries 1 | 67
Diabetes Mellitus, Insulin-Dependent 1 | 77
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Diarrhea 1 | 155
Fanconi syndrome 1 | 14
Fatty Liver 1 | 48
Fatty liver disease 1 | 86
Galactosemia 1 | 20
Giardiasis 1 | 10
Hyperuricemia 1 | 35
Myocardial Infarction 1 | 126
Oculogyric crisis 1 | 3
Pantothenate kinase-associated neurodegeneration 1 | 15
Polycythemia 1 | 19
Type 1 diabetes mellitus 1 | 104
maturity-onset diabetes of the young 1 | 30
non-inflammatory breast cancer 1 | 208

Tissue

Blood and immune system 22 | 17,994
Digestive Tract 22 | 18,472
Endocrine System 22 | 18,511
Female tissues 22 | 18,646
Liver and Pancreas 22 | 18,135
Nervous System 22 | 18,560
Urinary Tract 22 | 18,443
Cardiovascular System 21 | 17,957
Male tissues 21 | 17,968
Skin and soft tissues 21 | 18,114
Respiratory system 20 | 17,483

Target Family

Enzyme 15 | 4,146
Kinase 3 | 634
Transporter 3 | 473
Non-IDG 1 | 11,969

PathwayCommons: smpdb Pathway

Triosephosphate isomerase 22 | 22
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Tbio Transporter -1.36706 24.8 148
Hexokinase-2 HK2 Tchem Kinase -2.60415 391.1 373
Phosphoglycerate mutase 1 PGAM1 Tbio Enzyme -1.74935 55.3 185
Phosphoglucomutase-1 PGM1 Tbio Enzyme -2.68147 478.5 119
Glucose-6-phosphatase G6PC Tchem Enzyme -2.95061 870.2 71
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 Tbio Kinase -2.30499 191.2 424
Fructose-1,6-bisphosphatase 1 FBP1 Tchem Enzyme -2.05823 107.9 172
Pyruvate carboxylase, mitochondrial PC Tbio Enzyme -2.56120 349.9 207
Glucose-6-phosphate exchanger SLC37A4 SLC37A4 Tchem Transporter 0.00000 0