Development Level

Tbio 14 | 10,625
Tchem 4 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
abnormal bone mineralization 1 | 55
abnormal response to tactile s... 1 | 16
abnormal startle reflex 1 | 14
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating total pr... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased total body fat amoun... 1 | 186

Disease

ovarian cancer 12 | 8,492
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
glioblastoma 9 | 5,572
lung cancer 9 | 4,473
medulloblastoma, large-cell 9 | 6,234
osteosarcoma 9 | 7,933
ductal carcinoma in situ 8 | 1,745
psoriasis 8 | 6,685
Multiple myeloma 7 | 1,328
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
invasive ductal carcinoma 7 | 2,950
adult high grade glioma 6 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
primitive neuroectodermal tumor 6 | 3,031
ulcerative colitis 6 | 2,087
Lactic acidosis 5 | 43
astrocytic glioma 5 | 2,241
atypical teratoid / rhabdoid tumor 5 | 4,369
breast carcinoma 5 | 1,614
diabetes mellitus 5 | 1,663
fibroadenoma 5 | 557
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
Cancer 4 | 2,346
Pick disease 4 | 1,893
Pyruvate decarboxylase deficiency 4 | 15
colon cancer 4 | 1,475
lung adenocarcinoma 4 | 2,714
malignant mesothelioma 4 | 3,163
medulloblastoma 4 | 1,524
Leigh disease 3 | 81
Liver Cirrhosis, Experimental 3 | 108
Liver carcinoma 3 | 217
Obesity 3 | 616
adrenocortical carcinoma 3 | 1,427
lung carcinoma 3 | 2,844
non-small cell lung cancer 3 | 2,798
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
Atopic dermatitis 2 | 944
Biotin deficiency 2 | 9
Breast cancer 2 | 3,099
Carcinoma 2 | 2,147
Complications of Diabetes Mellitus 2 | 5
Diabetes Mellitus, Experimental 2 | 106
Diabetic neuropathy 2 | 8
Fatty liver disease 2 | 86
Gaucher's disease 2 | 25
Hyperglycemia 2 | 120
Kidney disease 2 | 397
Myocardial Ischemia 2 | 169
Prostatic Neoplasms 2 | 471
Pyruvate Dehydrogenase Complex Deficiency Disease 2 | 2
Squamous cell carcinoma of esophagus 2 | 82
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,157
ependymoma 2 | 2,514
gastric carcinoma 2 | 832
group 4 medulloblastoma 2 | 1,875
nephrosclerosis 2 | 329
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
Alcohol dependence 1 | 107
Alcoholic Intoxication, Chronic 1 | 41
Alcoholism 1 | 14
Amyloidosis 1 | 68
Anxiety Disorders 1 | 37
Biotinidase deficiency 1 | 11
Burkitt Lymphoma 1 | 19
Celiac disease 1 | 112
Cholangitis 1 | 20
Coffin-Lowry syndrome 1 | 10
Diabetic Retinopathy 1 | 53
Dowling-Degos disease 1 | 6
Drug-Induced Liver Injury 1 | 118
Dystonia 1 | 77
Echinococcosis 1 | 28
Esophageal Neoplasms 1 | 67
Esophageal cancer 1 | 30
Galactosemia 1 | 20
Hepatitis 1 | 61
Heroin dependence 1 | 30
Holocarboxylase synthetase deficiency 1 | 7
Hypoglycemia 1 | 81
Intracranial aneurysm 1 | 20
Kidney Failure, Chronic 1 | 45
Kidney failure 1 | 41
Liver Cirrhosis 1 | 101
Liver disease 1 | 219
Malignant neoplasm of esophagus 1 | 18
Melanoma 1 | 261
Myocardial Infarction 1 | 126
Pericarditis 1 | 14
Precancerous Conditions 1 | 69
Pyruvate Dehydrogenase E2 Deficiency 1 | 2
Renal Cell Carcinoma 1 | 199
Renal tubular acidosis 1 | 14
Substance abuse 1 | 55
Succinic semialdehyde dehydrogenase deficiency 1 | 16
Vascular Diseases 1 | 16
Weight Gain 1 | 87

Tissue

Blood and immune system 21 | 17,995
Cardiovascular System 21 | 17,958
Digestive Tract 21 | 18,473
Endocrine System 21 | 18,512
Female tissues 21 | 18,647
Liver and Pancreas 21 | 18,136
Male tissues 21 | 17,969
Nervous System 21 | 18,561
Respiratory system 21 | 17,484
Urinary Tract 21 | 18,444
Skin and soft tissues 20 | 18,115

Target Family

Enzyme 18 | 4,146
Kinase 2 | 634
Non-IDG 1 | 11,969

PathwayCommons: smpdb Pathway

Pyruvate kinase deficiency 21 | 21
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aldose reductase AKR1B1 Tclin Enzyme -3.25679 1851.0 302
Pyruvate kinase PKLR PKLR Tbio Kinase -2.35902 217.3 337
Probable D-lactate dehydrogenase, mitochondrial LDHD Tbio Enzyme -1.37820 21.9 118
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.97310 90.3 172
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -3.00925 983.0 487
Acyl-coenzyme A thioesterase 12 ACOT12 Tbio Enzyme -0.98720 8.55 79
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.62886 409.6 244
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB Tbio Enzyme -1.68544 44.6 137
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 Tbio Kinase -2.30499 191.2 424
Pyruvate carboxylase, mitochondrial PC Tbio Enzyme -2.56120 349.9 207