Development Level

Tbio 24 | 10,625
Tchem 2 | 1,890
Tclin 2 | 602

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal lens morphology 1 | 73
abnormal response to tactile s... 1 | 16
abnormal startle reflex 1 | 14
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating total pr... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lumbar vertebrae num... 1 | 62
embryonic lethality prior to t... 1 | 187
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased fasted circulating g... 1 | 68
prenatal lethality prior to he... 1 | 64

Disease

pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
ovarian cancer 17 | 8,491
glioblastoma 12 | 5,572
lung cancer 12 | 4,473
atypical teratoid / rhabdoid tumor 11 | 4,369
interstitial cystitis 11 | 2,299
osteosarcoma 11 | 7,933
psoriasis 11 | 6,685
ulcerative colitis 11 | 2,087
Maple syrup urine disease 10 | 25
medulloblastoma, large-cell 10 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
lung carcinoma 8 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
invasive ductal carcinoma 7 | 2,950
lung adenocarcinoma 7 | 2,714
3-Methylcrotonyl-CoA carboxylase deficiency 6 | 11
Breast cancer 6 | 3,098
Pick disease 6 | 1,893
Propionic acidemia 6 | 20
beta-ketothiolase deficiency 6 | 13
colon cancer 6 | 1,475
ependymoma 6 | 2,514
malignant mesothelioma 6 | 3,163
non-small cell lung cancer 6 | 2,798
pancreatic cancer 6 | 2,300
Isovaleric acidemia 5 | 14
Methylmalonic acidemia 5 | 39
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
cystic fibrosis 5 | 1,670
gastric carcinoma 5 | 832
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
medulloblastoma 5 | 1,524
oligodendroglioma 5 | 2,849
pediatric high grade glioma 5 | 2,712
pilocytic astrocytoma 5 | 3,086
primitive neuroectodermal tumor 5 | 3,031
3-methylglutaconic aciduria 4 | 29
Multiple acyl-CoA dehydrogenase deficiency 4 | 26
Multiple myeloma 4 | 1,327
Waldenstrons macroglobulinemia 4 | 764
breast carcinoma 4 | 1,614
ductal carcinoma in situ 4 | 1,745
nephrosclerosis 4 | 329
tuberculosis 4 | 1,563
Classic Maple Syrup Urine Disease 3 | 3
Hypoglycemia 3 | 81
Intermediate Maple Syrup Urine Disease 3 | 4
Intermittent Maple Syrup Urine Disease 3 | 3
Lactic acidosis 3 | 43
Leigh disease 3 | 81
Obesity 3 | 616
Succinic semialdehyde dehydrogenase deficiency 3 | 16
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
chronic lymphosyte leukemia 3 | 232
fibroadenoma 3 | 557
pituitary cancer 3 | 1,972
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency 2 | 2
3-methylcrotonyl CoA carboxylase 1 deficiency 2 | 2
Argininosuccinic aciduria 2 | 17
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Biotinidase deficiency 2 | 11
Coronary artery disease 2 | 240
Crohn's disease 2 | 304
Degenerative polyarthritis 2 | 93
Hyperargininemia 2 | 7
Metabolic acidosis 2 | 49
Myocardial Ischemia 2 | 169
Necrotizing Enterocolitis 2 | 17
Organic acidemia 2 | 3
Propionic acidemia, type II 2 | 2
Pyruvate decarboxylase deficiency 2 | 15
Reye syndrome 2 | 11
Seizures 2 | 95
Stomach Neoplasms 2 | 282
Systemic primary carnitine deficiency disease 2 | 16
Weight Gain 2 | 87
astrocytoma 2 | 1,493
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
posterior fossa group B ependymoma 2 | 1,530
primary pancreatic ductal adenocarcinoma 2 | 1,271
Acute cystitis 1 | 37
Adenocarcinoma of lung (disorder) 1 | 48
Alcoholism 1 | 14
Arthropathy 1 | 34
Diverticulitis 1 | 8
Esophageal cancer 1 | 30
Kidney Failure, Chronic 1 | 45
Leigh syndrome 1 | 34
Ornithine carbamoyltransferase deficiency 1 | 13
Psychomotor Disorders 1 | 7
Refractive error 1 | 43
Schistosomiasis 1 | 38
Scimitar syndrome 1 | 6
Synovitis 1 | 72

Tissue

Blood and immune system 28 | 17,994
Cardiovascular System 28 | 17,957
Digestive Tract 28 | 18,472
Endocrine System 28 | 18,511
Female tissues 28 | 18,646
Liver and Pancreas 28 | 18,135
Male tissues 28 | 17,968
Nervous System 28 | 18,560
Respiratory system 28 | 17,483
Skin and soft tissues 28 | 18,114
Urinary Tract 28 | 18,443

Target Family

Enzyme 28 | 4,146

PathwayCommons: smpdb Pathway

Propionic Acidemia 28 | 28
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
Isovaleryl-CoA dehydrogenase, mitochondrial IVD Tbio Enzyme -3.09487 1224.3 81
Methylglutaconyl-CoA hydratase, mitochondrial AUH Tbio Enzyme -1.98321 93.8 85
Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA Tbio Enzyme -2.06244 109.0 91
Propionyl-CoA carboxylase beta chain, mitochondrial PCCB Tbio Enzyme -1.75342 56.7 120
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -1.98724 94.7 165
Aldehyde oxidase AOX1 Tbio Enzyme -2.63655 413.2 143
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH Tchem Enzyme -1.21513 15.9 137
Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Tbio Enzyme -1.84444 67.4 341