Development Level

Tchem 11 | 1,890
Tbio 8 | 10,625
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
abnormal body wall morphology 1 | 7
abnormal coat/ hair morphology 1 | 18
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal inner nuclear... 1 | 5
decreased circulating triglyce... 1 | 83
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased circulating chloride... 1 | 43
increased rib number 1 | 41
microphthalmia 1 | 15
small epididymis 1 | 3
small seminal vesicle 1 | 6
small testis 1 | 37

Disease

ovarian cancer 14 | 8,492
osteosarcoma 11 | 7,933
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
psoriasis 10 | 6,685
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,163
active Crohn's disease 8 | 918
medulloblastoma, large-cell 8 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Pick disease 7 | 1,893
lung cancer 7 | 4,473
Antley-Bixler syndrome 6 | 15
ductal carcinoma in situ 6 | 1,745
Breast cancer 5 | 3,099
Smith-Lemli-Opitz syndrome 5 | 9
interstitial cystitis 5 | 2,299
pancreatic cancer 5 | 2,300
subependymal giant cell astrocytoma 5 | 2,287
Cancer 4 | 2,346
Cataract 4 | 104
Chondrodysplasia punctata 4 | 41
Congenital ichthyosiform erythroderma 4 | 27
atypical teratoid / rhabdoid tumor 4 | 4,369
breast carcinoma 4 | 1,614
glioblastoma 4 | 5,572
group 4 medulloblastoma 4 | 1,875
invasive ductal carcinoma 4 | 2,950
pituitary cancer 4 | 1,972
Chagas disease 3 | 34
Disseminated superficial actinic porokeratosis 3 | 4
Liver carcinoma 3 | 217
Mevalonic aciduria 3 | 12
Multiple myeloma 3 | 1,328
Porokeratosis, Disseminated Superficial Actinic 3 | 4
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 477
adrenocortical carcinoma 3 | 1,427
astrocytic glioma 3 | 2,241
astrocytoma 3 | 1,493
chronic rhinosinusitis 3 | 512
ependymoma 3 | 2,514
group 3 medulloblastoma 3 | 2,254
lung adenocarcinoma 3 | 2,714
oligodendroglioma 3 | 2,849
pediatric high grade glioma 3 | 2,712
primitive neuroectodermal tumor 3 | 3,031
tuberculosis 3 | 1,563
Atherosclerosis 2 | 275
Atopic dermatitis 2 | 944
Cardiovascular system disease 2 | 194
Coronary artery disease 2 | 240
Hydrolethalus syndrome 2 | 128
Intellectual disability 2 | 573
Onychomycosis due to dermatophyte 2 | 2
Osteoporosis 2 | 259
Pityriasis versicolor 2 | 18
Porokeratosis of Mibelli 2 | 2
Tinea corporis 2 | 25
Tinea cruris 2 | 12
Tinea pedis 2 | 30
X-linked chondrodysplasia punctata 2 | 3
adult high grade glioma 2 | 2,148
diabetes mellitus 2 | 1,663
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 436
hepatocellular carcinoma 2 | 550
pilocytic astrocytoma 2 | 3,086
posterior fossa group B ependymoma 2 | 1,530
primary pancreatic ductal adenocarcinoma 2 | 1,271
progressive supranuclear palsy 2 | 674
spina bifida 2 | 1,064
Anxiety 1 | 24
Aphthous stomatitis 1 | 3
Aspergillosis 1 | 23
Brucellosis 1 | 24
Candidiasis 1 | 48
Carcinoma of female breast 1 | 20
Familial Mediterranean fever 1 | 12
Hypertriglyceridemia 1 | 18
Infiltrating duct carcinoma of breast 1 | 4
Keratosis 1 | 34
Kidney Failure, Chronic 1 | 45
Lipoidosis 1 | 19
Liver Neoplasms, Experimental 1 | 48
Muckle-Wells syndrome 1 | 11
Myocardial Infarction Prevention 1 | 7
Niemann-Pick disease, type C 1 | 5
Ovulation induction 1 | 4
Pharyngitis 1 | 17
Porokeratosis 7, multiple types 1 | 1
Prevention of Breast Carcinoma 1 | 5
Primary Prevention of Coronary Heart Disease 1 | 4
Prinzmetal angina 1 | 6
Pyloric stenosis 1 | 9
Pyoderma gangrenosum 1 | 9
Sertoli cell-only syndrome 1 | 36
Sleeping sickness 1 | 37
Urethral stricture 1 | 7
Waterhouse-Friderichsen syndrome 1 | 11

Tissue

Blood and immune system 21 | 17,995
Cardiovascular System 21 | 17,958
Digestive Tract 21 | 18,473
Endocrine System 21 | 18,512
Female tissues 21 | 18,647
Liver and Pancreas 21 | 18,136
Male tissues 21 | 17,969
Nervous System 21 | 18,561
Respiratory system 21 | 17,484
Skin and soft tissues 21 | 18,115
Urinary Tract 21 | 18,444

Target Family

Enzyme 20 | 4,146
Kinase 1 | 634

PathwayCommons: smpdb Pathway

Pravastatin Action Pathway 21 | 21
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.04287 104.2 131
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.90663 819.0 231
Geranylgeranyl pyrophosphate synthase GGPS1 Tchem Enzyme -2.27421 178.1 250
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.09712 12.4 80
Squalene synthase FDFT1 Tchem Enzyme -2.53973 343.3 251
Lysosomal acid lipase/cholesteryl ester hydrolase LIPA Tchem Enzyme -2.76410 567.4 132
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tbio Enzyme -1.59059 37.3 107
Acetyl-CoA acetyltransferase, cytosolic ACAT2 Tbio Enzyme -1.75917 52.8 236
Sterol O-acyltransferase 1 SOAT1 Tchem Enzyme -2.12303 133.2 107
Lanosterol synthase LSS Tchem Enzyme -2.16455 132.2 73