Development Level

Tclin 27 | 602
Tbio 20 | 10,625
Tchem 12 | 1,890

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102

IMPC Phenotype

preweaning lethality, complete... 5 | 633
embryonic lethality prior to t... 3 | 187
abnormal behavior 2 | 226
decreased fasted circulating g... 2 | 49
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal sensory capabilities-... 1 | 3
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating iron lev... 1 | 25
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
enlarged heart 1 | 111
increased bone mineral content 1 | 92
increased circulating magnesiu... 1 | 10
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
limb grasping 1 | 35
small epididymis 1 | 3

Disease

psoriasis 33 | 6,685
glioblastoma 27 | 5,572
medulloblastoma, large-cell 27 | 6,234
ovarian cancer 27 | 8,491
osteosarcoma 22 | 7,933
primitive neuroectodermal tumor 22 | 3,031
Atrial Fibrillation 21 | 110
oligodendroglioma 21 | 2,849
lung cancer 20 | 4,473
lung adenocarcinoma 19 | 2,714
Carcinoma 18 | 2,147
atypical teratoid / rhabdoid tumor 18 | 4,369
lung carcinoma 18 | 2,844
colon cancer 17 | 1,475
ependymoma 17 | 2,514
Breast cancer 16 | 3,098
Heart disease 16 | 279
astrocytic glioma 15 | 2,241
subependymal giant cell astrocytoma 15 | 2,287
Long QT syndrome 14 | 53
Pick disease 14 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
invasive ductal carcinoma 14 | 2,950
non-small cell lung cancer 14 | 2,798
pediatric high grade glioma 14 | 2,712
pilocytic astrocytoma 14 | 3,086
adult high grade glioma 13 | 2,148
diabetes mellitus 13 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
atypical teratoid/rhabdoid tumor 12 | 1,095
malignant mesothelioma 12 | 3,163
pancreatic cancer 12 | 2,300
pituitary cancer 12 | 1,972
Chronic heart failure 11 | 46
Epilepsy 11 | 346
ductal carcinoma in situ 11 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
Hypertension 10 | 293
acute quadriplegic myopathy 10 | 1,157
group 3 medulloblastoma 10 | 2,254
group 4 medulloblastoma 10 | 1,875
Congestive heart failure 9 | 36
adrenocortical carcinoma 9 | 1,427
cystic fibrosis 9 | 1,670
fibroadenoma 9 | 557
interstitial cystitis 9 | 2,299
posterior fossa group B ependymoma 9 | 1,530
Cardiomyopathy 8 | 110
Poisoning by digitalis glycoside 8 | 8
medulloblastoma 8 | 1,524
primary pancreatic ductal adenocarcinoma 8 | 1,271
Brugada syndrome 7 | 26
Congenital long QT syndrome 7 | 8
Dilated cardiomyopathy 7 | 51
Duchenne muscular dystrophy 7 | 602
Familial isolated dilated cardiomyopathy 7 | 41
Heart conduction disease 7 | 65
Hypertensive disease 7 | 193
Hypertensive disorder 7 | 58
Romano-Ward Syndrome 7 | 12
Short QT syndrome 7 | 12
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
sonic hedgehog group medulloblastoma 7 | 1,482
Atopic dermatitis 6 | 944
Cardiac arrhythmia 6 | 26
Cardiomyopathies 6 | 90
Cardiomyopathy, Dilated 6 | 47
Cerebrovascular disease 6 | 231
Familial atrial fibrillation 6 | 16
Hypertrophic Cardiomyopathy 6 | 56
Long QT syndrome 1 6 | 12
Myocardial Ischemia 6 | 169
Parkinson's disease 6 | 364
Timothy syndrome 6 | 12
pancreatic carcinoma 6 | 567
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
posterior fossa group A ependymoma 6 | 1,511
ulcerative colitis 6 | 2,087
Brugada Syndrome (disorder) 5 | 15
Cardiomyopathy, Hypertrophic, Familial 5 | 21
Coronary artery disease 5 | 240
Heart failure 5 | 80
Hypokalemia 5 | 40
Schizophrenia 5 | 503
Sudden infant death syndrome 5 | 34
Tachycardia, Ventricular 5 | 10
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
Down syndrome 4 | 548
Endometriosis 4 | 535
Multiple Sclerosis 4 | 498
Waldenstrons macroglobulinemia 4 | 764
active Crohn's disease 4 | 918
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 550
juvenile dermatomyositis 4 | 1,189
spina bifida 4 | 1,064
tuberculosis 4 | 1,563

Tissue

Blood and immune system 59 | 17,994
Cardiovascular System 59 | 17,957
Digestive Tract 59 | 18,472
Endocrine System 59 | 18,511
Female tissues 59 | 18,646
Liver and Pancreas 59 | 18,135
Male tissues 59 | 17,968
Nervous System 59 | 18,560
Respiratory system 59 | 17,483
Skin and soft tissues 59 | 18,114
Urinary Tract 59 | 18,443

Target Family

Ion Channel 23 | 341
Non-IDG 16 | 11,969
Transporter 11 | 473
Enzyme 4 | 4,146
GPCR 3 | 408
Kinase 2 | 634

PathwayCommons: smpdb Pathway

Metoprolol Action Pathway 59 | 59
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Potassium voltage-gated channel subfamily H member 2 KCNH2 Tclin Ion Channel -3.19173 1625.2 221
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C Tclin Ion Channel -2.72211 489.2 316
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2 Tclin Transporter -1.33849 19.3 155
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.87621 876.7 339
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.04336 8.71 102
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.49899 328.4 157
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.83237 679.4 189
Tropomyosin beta chain TPM2 Tbio Non-IDG -2.34359 213.2 175