Development Level

Tbio 14 | 10,625
Tchem 11 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
decreased total body fat amoun... 2 | 186
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal retina morphology 1 | 100
decreased body weight 1 | 174
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased leukocyte cell numbe... 1 | 54
decreased prepulse inhibition 1 | 52
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
immune system phenotype 1 | 17
increased exploration in new e... 1 | 56
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128

Disease

ovarian cancer 16 | 8,484
psoriasis 15 | 6,685
medulloblastoma, large-cell 11 | 6,234
osteosarcoma 11 | 7,933
adrenocortical carcinoma 9 | 1,427
Cancer 8 | 2,346
invasive ductal carcinoma 8 | 2,950
malignant mesothelioma 8 | 3,162
non-small cell lung cancer 8 | 2,798
Homocystinuria 7 | 23
Hyperhomocysteinemia 7 | 34
lung adenocarcinoma 7 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
atypical teratoid / rhabdoid tumor 6 | 4,369
ductal carcinoma in situ 6 | 1,745
glioblastoma 6 | 5,572
group 3 medulloblastoma 6 | 2,254
lung cancer 6 | 4,466
ulcerative colitis 6 | 2,087
Rheumatoid Arthritis 5 | 1,160
breast carcinoma 5 | 1,614
dermatomyositis 5 | 933
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
nephrosclerosis 5 | 329
pancreatic cancer 5 | 2,300
primitive neuroectodermal tumor 5 | 3,031
tuberculosis 5 | 1,557
Cleft Lip 4 | 91
Cleft palate 4 | 125
Colorectal Neoplasms 4 | 217
Lymphoma, Non-Hodgkin 4 | 22
Mammary Neoplasms 4 | 410
Multiple myeloma 4 | 1,327
astrocytic glioma 4 | 2,241
atypical teratoid/rhabdoid tumor 4 | 1,095
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
posterior fossa group A ependymoma 4 | 1,511
primary pancreatic ductal adenocarcinoma 4 | 1,271
spina bifida 4 | 1,064
Adverse reaction to drug 3 | 54
Alzheimer's disease 3 | 644
Breast cancer 3 | 3,094
Dementia 3 | 129
Down syndrome 3 | 548
Drug-Induced Liver Injury 3 | 118
Hypermethioninemia 3 | 12
Neural Tube Defects 3 | 27
Polycystic Ovary Syndrome 3 | 332
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 501
Sleeping sickness 3 | 37
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 918
adult high grade glioma 3 | 2,148
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
nervous system disorder 3 | 53
oligodendroglioma 3 | 2,849
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
Anemia 2 | 252
Atherosclerosis 2 | 275
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Cardiovascular system disease 2 | 194
Chronic Lymphocytic Leukemia 2 | 242
Colonic Neoplasms 2 | 126
Coronary artery disease 2 | 240
Coronary heart disease 2 | 59
Endometriosis 2 | 535
Female infertility 2 | 28
Gestational trophoblastic neoplasia 2 | 14
Heart disease 2 | 279
Hypertension 2 | 287
MYELODYSPLASTIC SYNDROME 2 | 36
Malignant tumor of head and/or neck 2 | 15
Methylmalonic acidemia 2 | 39
Neoplasm Metastasis 2 | 138
Neural tube defect, folate-sensitive 2 | 4
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Pick disease 2 | 1,893
Stomach Neoplasms 2 | 282
acute quadriplegic myopathy 2 | 1,157
astrocytoma 2 | 1,493
colon cancer 2 | 1,475
diabetes mellitus 2 | 1,663
ependymoma 2 | 2,514
esophageal adenocarcinoma 2 | 737
hearing impairment 2 | 40
inflammatory breast cancer 2 | 404
nasopharyngeal carcinoma 2 | 1,056
pediatric high grade glioma 2 | 2,712
progressive supranuclear palsy 2 | 674
sonic hedgehog group medulloblastoma 2 | 1,482

Tissue

Blood and immune system 27 | 17,995
Cardiovascular System 27 | 17,958
Digestive Tract 27 | 18,473
Endocrine System 27 | 18,512
Female tissues 27 | 18,647
Liver and Pancreas 27 | 18,136
Male tissues 27 | 17,969
Nervous System 27 | 18,561
Respiratory system 27 | 17,484
Skin and soft tissues 27 | 18,115
Urinary Tract 27 | 18,444

Target Family

Enzyme 26 | 4,146
Transporter 1 | 473

PathwayCommons: smpdb Pathway

Methylenetetrahydrofolate Redu... 27 | 27
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Choline dehydrogenase, mitochondrial CHDH Tbio Enzyme -1.38953 24.8 68
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.31042 21.3 114
5-formyltetrahydrofolate cyclo-ligase MTHFS Tbio Enzyme -1.10551 12.8 142
Dihydrofolate reductase DHFR Tclin Enzyme -2.97865 960.4 158
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.72795 575.2 40
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.18544 160.5 238
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.64329 42.3 94
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.17780 163.1 71
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.17437 1499.1 118
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.13310 1415.1 1015