Development Level

Tclin 28 | 602
Tbio 20 | 10,625
Tchem 13 | 1,890

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to t... 3 | 187
abnormal behavior 2 | 226
decreased fasted circulating g... 2 | 49
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal sensory capabilities/... 1 | 3
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating iron lev... 1 | 25
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
enlarged heart 1 | 111
increased bone mineral content 1 | 92
increased circulating magnesiu... 1 | 10
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
limb grasping 1 | 35
small epididymis 1 | 3

Disease

psoriasis 35 | 6,685
medulloblastoma, large-cell 29 | 6,234
ovarian cancer 28 | 8,484
glioblastoma 27 | 5,572
osteosarcoma 24 | 7,933
oligodendroglioma 22 | 2,849
primitive neuroectodermal tumor 22 | 3,031
Atrial Fibrillation 21 | 110
lung cancer 20 | 4,466
lung adenocarcinoma 19 | 2,713
Carcinoma 18 | 2,147
atypical teratoid / rhabdoid tumor 18 | 4,369
ependymoma 18 | 2,514
lung carcinoma 18 | 2,844
colon cancer 17 | 1,475
Breast cancer 16 | 3,094
Heart disease 16 | 279
astrocytic glioma 16 | 2,241
subependymal giant cell astrocytoma 15 | 2,287
Long QT syndrome 14 | 52
Pick disease 14 | 1,893
diabetes mellitus 14 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
invasive ductal carcinoma 14 | 2,950
non-small cell lung cancer 14 | 2,798
pediatric high grade glioma 14 | 2,712
pilocytic astrocytoma 14 | 3,086
adult high grade glioma 13 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
Epilepsy 12 | 346
atypical teratoid/rhabdoid tumor 12 | 1,095
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
malignant mesothelioma 12 | 3,162
pancreatic cancer 12 | 2,300
pituitary cancer 12 | 1,972
Chronic heart failure 11 | 46
ductal carcinoma in situ 11 | 1,745
Hypertension 10 | 287
acute quadriplegic myopathy 10 | 1,157
group 3 medulloblastoma 10 | 2,254
group 4 medulloblastoma 10 | 1,875
Congestive heart failure 9 | 30
adrenocortical carcinoma 9 | 1,427
cystic fibrosis 9 | 1,665
fibroadenoma 9 | 557
interstitial cystitis 9 | 2,299
posterior fossa group B ependymoma 9 | 1,530
Cardiomyopathy 8 | 110
Poisoning by digitalis glycoside 8 | 8
medulloblastoma 8 | 1,524
primary pancreatic ductal adenocarcinoma 8 | 1,271
Brugada syndrome 7 | 26
Congenital long QT syndrome 7 | 8
Dilated cardiomyopathy 7 | 50
Duchenne muscular dystrophy 7 | 602
Heart conduction disease 7 | 65
Hypertensive disease 7 | 193
Hypertensive disorder 7 | 58
Romano-Ward Syndrome 7 | 12
Schizophrenia 7 | 501
Short QT syndrome 7 | 12
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
sonic hedgehog group medulloblastoma 7 | 1,482
Atopic dermatitis 6 | 944
Cardiomyopathies 6 | 90
Cardiomyopathy, Dilated 6 | 47
Cerebrovascular disease 6 | 231
Coronary artery disease 6 | 240
Familial atrial fibrillation 6 | 16
Hypertrophic Cardiomyopathy 6 | 56
Myocardial Ischemia 6 | 169
Parkinson's disease 6 | 364
Timothy syndrome 6 | 12
pancreatic carcinoma 6 | 567
posterior fossa group A ependymoma 6 | 1,511
ulcerative colitis 6 | 2,087
Brugada Syndrome (disorder) 5 | 15
Cancer 5 | 2,346
Cardiomyopathy, Hypertrophic, Familial 5 | 21
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
Heart failure 5 | 80
Hypokalemia 5 | 40
Sudden infant death syndrome 5 | 33
Tachycardia, Ventricular 5 | 10
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
tuberculosis 5 | 1,557
Adenoma 4 | 165
Down syndrome 4 | 548
Endometriosis 4 | 535
Multiple Sclerosis 4 | 498
Status Epilepticus 4 | 85
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 918
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 532
juvenile dermatomyositis 4 | 1,189
spina bifida 4 | 1,064

Tissue

Blood and immune system 61 | 17,995
Cardiovascular System 61 | 17,958
Digestive Tract 61 | 18,473
Endocrine System 61 | 18,512
Female tissues 61 | 18,647
Liver and Pancreas 61 | 18,136
Male tissues 61 | 17,969
Nervous System 61 | 18,561
Respiratory system 61 | 17,484
Skin and soft tissues 61 | 18,115
Urinary Tract 61 | 18,444

Target Family

Ion Channel 23 | 341
Non-IDG 17 | 11,971
Transporter 11 | 473
Enzyme 5 | 4,146
GPCR 3 | 406
Kinase 2 | 634

PathwayCommons: smpdb Pathway

Lidocaine (Antiarrhythmic) Act... 61 | 61
Phenytoin (Antiarrhythmic) Act... 79 | 79
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.02258 8.71 102
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2 Tclin Transporter -2.04732 117.9 108
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3 Tclin Transporter -2.09703 131.9 103
G protein-activated inward rectifier potassium channel 4 KCNJ5 Tchem Ion Channel -2.24687 186.6 114
G protein-activated inward rectifier potassium channel 1 KCNJ3 Tchem Ion Channel -2.31340 205.5 237
Troponin T, slow skeletal muscle TNNT1 Tbio Non-IDG -3.42398 2740.6 124
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.63112 407.4 169
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -1.96950 86.9 104