Development Level

Tbio 7 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal coat appearance 1 | 25
decreased body weight 1 | 174
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased leukocyte cell numbe... 1 | 54
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased exploration in new e... 1 | 56
increased or absent threshold ... 1 | 128

Disease

psoriasis 6 | 6,685
Rheumatoid Arthritis 5 | 1,160
adrenocortical carcinoma 5 | 1,427
glioblastoma 5 | 5,572
non-small cell lung cancer 5 | 2,798
osteosarcoma 5 | 7,933
ovarian cancer 5 | 8,484
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Colorectal Neoplasms 4 | 217
atypical teratoid/rhabdoid tumor 4 | 1,095
lung cancer 4 | 4,466
medulloblastoma, large-cell 4 | 6,234
ulcerative colitis 4 | 2,087
Cancer 3 | 2,346
Cleft Lip 3 | 91
Cleft palate 3 | 125
Drug-Induced Liver Injury 3 | 118
Hyperhomocysteinemia 3 | 34
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
invasive ductal carcinoma 3 | 2,950
malignant mesothelioma 3 | 3,162
nephrosclerosis 3 | 329
posterior fossa group A ependymoma 3 | 1,511
primitive neuroectodermal tumor 3 | 3,031
Acute lymphoid leukemia 2 | 25
Adverse reaction to drug 2 | 54
Alzheimer's disease 2 | 644
Anemia 2 | 252
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Breast cancer 2 | 3,094
Burkitt's lymphoma 2 | 15
Carcinoma of female breast 2 | 20
Coronary heart disease 2 | 59
Endometriosis 2 | 535
Female infertility 2 | 28
Gestational trophoblastic neoplasia 2 | 14
Homocystinuria 2 | 23
Juvenile rheumatoid arthritis 2 | 104
Lymphoma, Non-Hodgkin 2 | 22
Malignant mesothelioma of pleura 2 | 7
Malignant tumor of head and/or neck 2 | 15
Malignant tumor of lung 2 | 5
Mammary Neoplasms 2 | 410
Meningeal Leukemia 2 | 7
Mycosis fungoides 2 | 28
Neoplasm Metastasis 2 | 138
Neural Tube Defects 2 | 27
Neural tube defect, folate-sensitive 2 | 4
Non-Hodgkin's lymphoma 2 | 22
Osteosarcoma of bone 2 | 6
Pancytopenia 2 | 9
Polycystic Ovary Syndrome 2 | 332
active Crohn's disease 2 | 918
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
diabetes mellitus 2 | 1,663
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,713
nasopharyngeal carcinoma 2 | 1,056
nervous system disorder 2 | 53
pituitary cancer 2 | 1,972
spina bifida 2 | 1,064
tuberculosis 2 | 1,557
Arsenic Poisoning 1 | 59
Blood Coagulation Disorders, Inherited 1 | 1
Blood pressure finding 1 | 56
Cervical Intraepithelial Neoplasia 1 | 2
Coronary Restenosis 1 | 8
Dermatologic disorders 1 | 65
Gastrointestinal Stromal Tumors 1 | 8
HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY 1 | 1
Inflammatory disease of mucous membrane 1 | 8
Leukoencephalopathies 1 | 7
Leukopenia 1 | 42
Liver diseases 1 | 66
Lung Neoplasms 1 | 171
Lymphoma 1 | 56
Lymphoma, Follicular 1 | 20
Malnutrition 1 | 3
Maxillofacial Abnormalities 1 | 1
Meningomyelocele 1 | 4
Microsatellite Instability 1 | 12
Microvascular Angina 1 | 1
Necrosis 1 | 51
Neutropenia 1 | 78
Pulmonary Embolism 1 | 45
Sinus Thrombosis, Intracranial 1 | 2
Spinal Cord Diseases 1 | 3
Systemic arterial pressure 1 | 56
Thrombocytopenia 1 | 105
Thrombophilia 1 | 36
Thyrotoxicosis 1 | 38
Vascular Diseases 1 | 16
Venous Thrombosis 1 | 21

Tissue

Blood and immune system 12 | 17,995
Cardiovascular System 12 | 17,958
Digestive Tract 12 | 18,473
Endocrine System 12 | 18,512
Female tissues 12 | 18,647
Liver and Pancreas 12 | 18,136
Male tissues 12 | 17,969
Nervous System 12 | 18,561
Respiratory system 12 | 17,484
Skin and soft tissues 12 | 18,115
Urinary Tract 12 | 18,444

Target Family

Enzyme 11 | 4,146
Transporter 1 | 473

PathwayCommons: smpdb Pathway

Folate malabsorption, heredita... 12 | 12
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.31042 21.3 114
5-formyltetrahydrofolate cyclo-ligase MTHFS Tbio Enzyme -1.10551 12.8 142
Dihydrofolate reductase DHFR Tclin Enzyme -2.97865 960.4 158
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.18544 160.5 238
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.64329 42.3 94
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.17780 163.1 71
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.65857 4846.8 245
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.92199 82.5 84
Gamma-glutamyl hydrolase GGH Tchem Enzyme -2.40280 256.1 190
Cytosolic 10-formyltetrahydrofolate dehydrogenase ALDH1L1 Tbio Enzyme -1.67818 54.1 206