Development Level

Tbio 5 | 10,625
Tchem 5 | 1,890
Tclin 1 | 602

IMPC Phenotype

decreased bone mineral content 1 | 157
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased lean body mass 1 | 195
increased heart rate variabili... 1 | 4
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
preweaning lethality, incomple... 1 | 260

Disease

invasive ductal carcinoma 6 | 2,950
psoriasis 6 | 6,685
ductal carcinoma in situ 5 | 1,745
non-small cell lung cancer 5 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Atopic dermatitis 4 | 944
breast carcinoma 4 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
malignant mesothelioma 4 | 3,163
medulloblastoma, large-cell 4 | 6,234
osteosarcoma 4 | 7,933
ovarian cancer 4 | 8,491
Type 2 diabetes mellitus 3 | 192
Vascular disease 3 | 281
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
diabetes mellitus 3 | 1,663
glioblastoma 3 | 5,572
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
lung adenocarcinoma 3 | 2,714
ulcerative colitis 3 | 2,087
Atherosclerosis 2 | 275
Breast cancer 2 | 3,098
Cancer 2 | 2,346
Cardiovascular system disease 2 | 194
Coronary artery disease 2 | 240
Diabetes Mellitus, Experimental 2 | 106
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Diabetes Mellitus, Noninsulin-Dependent 2 | 31
Hypercholesterolemia, Familial 2 | 18
Hyperglycemia 2 | 120
Hyperlipidemia 2 | 25
Lipid metabolism disorder 2 | 102
Metabolic syndrome X 2 | 155
astrocytoma 2 | 1,493
atypical teratoid / rhabdoid tumor 2 | 4,369
cutaneous lupus erythematosus 2 | 1,056
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 557
group 4 medulloblastoma 2 | 1,875
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
primitive neuroectodermal tumor 2 | 3,031
Age related macular degeneration 1 | 84
Amyotrophic Lateral Sclerosis 1 | 432
Animal Mammary Neoplasms 1 | 135
Cardiomyopathies 1 | 90
Cardiovascular Diseases 1 | 50
Cataract 1 | 104
Colonic Neoplasms 1 | 126
Coronary heart disease 1 | 59
Diabetic Retinopathy 1 | 53
Diabetic neuropathy 1 | 8
Disease Progression 1 | 125
Down syndrome 1 | 548
Endometrial Neoplasms 1 | 50
Endometriosis 1 | 535
Galactosemia 1 | 20
Heart conduction disease 1 | 65
Hepatitis 1 | 61
Hepatitis B 1 | 103
Hepatitis C 1 | 90
Hypercholesterolemia 1 | 27
Hyperinsulinism 1 | 63
Hypertension 1 | 293
Hypertensive disease 1 | 193
Hypertriglyceridemia 1 | 18
Idiopathic Membranous Glomerulonephritis 1 | 18
Insulin Resistance 1 | 50
Kabuki syndrome 1 | 29
Kidney disease 1 | 397
Macular degeneration 1 | 44
Mammary Neoplasms, Experimental 1 | 149
Melanoma 1 | 261
Methylmalonic acidemia 1 | 39
Motion sickness 1 | 32
Necrosis 1 | 51
Neuropathy 1 | 210
Osteoporosis 1 | 259
Pancreatitis 1 | 97
Peripheral vascular disease 1 | 90
Status Epilepticus 1 | 85
Stomach Neoplasms 1 | 282
active ulcerative colitis 1 | 477
adult high grade glioma 1 | 2,148
aldosterone-producing adenoma 1 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
chronic kidney disease 1 | 90
chronic lymphosyte leukemia 1 | 232
colon cancer 1 | 1,475
cystic fibrosis 1 | 1,670
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
medulloblastoma 1 | 1,524
mucosa-associated lymphoid tissue lymphoma 1 | 480
pituitary cancer 1 | 1,972
tuberculosis 1 | 1,563
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 11 | 17,994
Cardiovascular System 11 | 17,957
Digestive Tract 11 | 18,472
Endocrine System 11 | 18,511
Female tissues 11 | 18,646
Liver and Pancreas 11 | 18,135
Male tissues 11 | 17,968
Nervous System 11 | 18,560
Respiratory system 11 | 17,483
Skin and soft tissues 11 | 18,114
Urinary Tract 11 | 18,443

Target Family

Enzyme 10 | 4,146
Kinase 1 | 634

PathwayCommons: smpdb Pathway

Familial lipoprotein lipase de... 11 | 11
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phospholipid phosphatase 2 PLPP2 Tbio Enzyme -1.33905 20.8 93
Phospholipid phosphatase 1 PLPP1 Tbio Enzyme -1.42492 26.3 109
Hepatic triacylglycerol lipase LIPC Tchem Enzyme -2.55639 388.4 241
Glycerate kinase GLYCTK Tbio Kinase -1.31760 19.4 162
Aldose reductase AKR1B1 Tclin Enzyme -3.25679 1851.0 302
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic GPD1 Tbio Enzyme -1.73230 53.1 201
Glycerol-3-phosphate dehydrogenase, mitochondrial GPD2 Tchem Enzyme -1.83747 66.9 165
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tchem Enzyme -1.86960 75.6 147
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha AGPAT1 Tbio Enzyme -1.01462 7.85 75
Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 Tchem Enzyme -2.11650 137.8 276