Development Level

Tbio 21 | 10,625
Tclin 2 | 602

IMPC Term

decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating total pr... 2 | 41
preweaning lethality, complete... 2 | 633
thrombocytopenia 2 | 46
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal response to tactile s... 1 | 16
abnormal skin appearance 1 | 8
abnormal startle reflex 1 | 14
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating thyroxin... 1 | 5
decreased circulating triglyce... 1 | 83
decreased circulating unsatura... 1 | 1
decreased food intake 1 | 6
decreased grip strength 1 | 123
decreased leukocyte cell numbe... 1 | 54
decreased mean platelet volume 1 | 12
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
female infertility 1 | 34
herniated abdominal wall 1 | 4
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased body weight 1 | 42
increased circulating bilirubi... 1 | 16
increased heart rate variabili... 1 | 4
increased rib number 1 | 41
male infertility 1 | 62
microphthalmia 1 | 15
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15

Disease

pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
psoriasis 13 | 6,685
pancreatic cancer 11 | 2,300
osteosarcoma 10 | 7,933
ovarian cancer 10 | 8,484
lung cancer 9 | 4,466
non-small cell lung cancer 9 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
medulloblastoma, large-cell 8 | 6,234
Breast cancer 6 | 3,094
atypical teratoid / rhabdoid tumor 6 | 4,369
glioblastoma 6 | 5,572
pediatric high grade glioma 6 | 2,712
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,271
Multiple myeloma 5 | 1,327
adrenocortical carcinoma 5 | 1,427
lung adenocarcinoma 5 | 2,713
malignant mesothelioma 5 | 3,162
posterior fossa group B ependymoma 5 | 1,530
Cancer 4 | 2,346
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 2,254
group 4 medulloblastoma 4 | 1,875
interstitial cystitis 4 | 2,299
invasive ductal carcinoma 4 | 2,950
nasopharyngeal carcinoma 4 | 1,056
oligodendroglioma 4 | 2,849
Alcohol dependence 3 | 107
Glycine encephalopathy 3 | 28
Intellectual disability 3 | 573
Kidney disease 3 | 396
Schizophrenia 3 | 501
Serine deficiency 3 | 9
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
breast carcinoma 3 | 1,614
nephrosclerosis 3 | 329
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
pilocytic astrocytoma 3 | 3,086
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
AGAT deficiency 2 | 6
Amino Acid Metabolism, Inborn Errors 2 | 13
Atopic dermatitis 2 | 944
Creatine transporter deficiency 2 | 4
Crohn's disease 2 | 304
Down syndrome 2 | 548
Guanidinoacetate methyltransferase deficiency 2 | 4
Heroin dependence 2 | 30
Mammary Neoplasms 2 | 410
Microcephaly 2 | 149
Neu-Laxova syndrome 2 | 2
Nonketotic Hyperglycinemia 2 | 3
Polycystic Ovary Syndrome 2 | 332
Prostate cancer 2 | 172
Prostatic Neoplasms 2 | 471
Substance abuse 2 | 55
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis 2 | 1,665
dermatomyositis 2 | 933
fibroadenoma 2 | 557
hepatocellular carcinoma 2 | 532
juvenile dermatomyositis 2 | 1,189
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
primary Sjogren syndrome 2 | 789
primitive neuroectodermal tumor 2 | 3,031
sonic hedgehog group medulloblastoma 2 | 1,482
Alcoholic Intoxication, Chronic 1 | 41
Animal Mammary Neoplasms 1 | 136
Antisocial personality disorder 1 | 9
Charcot-Marie-Tooth disease 1 | 74
Erythropoietic protoporphyria 1 | 15
Esophageal Neoplasms 1 | 67
Exhibitionism 1 | 7
Heart failure 1 | 80
Hepatic encephalopathy 1 | 25
Intracranial aneurysm 1 | 20
Kabuki syndrome 1 | 27
Liver Cirrhosis, Experimental 1 | 108
Liver disease 1 | 219
MYELODYSPLASTIC SYNDROME 1 | 36
Malignant neoplasm of esophagus 1 | 18
Mammary Neoplasms, Experimental 1 | 150
Melancholia 1 | 12
Melanoma 1 | 261
Muscular atrophy 1 | 67
Sideroblastic anemia 1 | 18
Squamous cell carcinoma of esophagus 1 | 82
Succinic semialdehyde dehydrogenase deficiency 1 | 16
interstitial lung disease 1 | 291
sarcoidosis 1 | 358

Tissue

Blood and immune system 23 | 17,995
Cardiovascular System 23 | 17,958
Digestive Tract 23 | 18,473
Endocrine System 23 | 18,512
Female tissues 23 | 18,647
Liver and Pancreas 23 | 18,136
Male tissues 23 | 17,969
Nervous System 23 | 18,561
Respiratory system 23 | 17,484
Skin and soft tissues 23 | 18,115
Urinary Tract 23 | 18,444

Target Family

Enzyme 22 | 4,146
Kinase 1 | 634

PathwayCommons: smpdb Pathway

Dimethylglycine Dehydrogenase ... 23 | 23
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.31313 210.4 193
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.68278 53.7 117
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.33647 218.9 181
Glycerate kinase GLYCTK Tbio Kinase -1.27397 19.4 162
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.12793 1317.4 261
Phosphoserine aminotransferase PSAT1 Tbio Enzyme -2.22389 167.4 113
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.74695 57.8 136
Glycine--tRNA ligase GARS Tbio Enzyme -2.59112 388.4 129
Dimethylglycine dehydrogenase, mitochondrial DMGDH Tbio Enzyme -1.34540 23.0 99
Glycine N-methyltransferase GNMT Tbio Enzyme -1.54868 41.0 182