Development Level

Tbio 20 | 10,625
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71

Disease

ovarian cancer 16 | 8,484
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Multiple myeloma 10 | 1,327
psoriasis 10 | 6,685
osteosarcoma 8 | 7,933
medulloblastoma, large-cell 7 | 6,234
Lactic acidosis 5 | 42
Leigh disease 5 | 81
Neoplastic Syndromes, Hereditary 5 | 48
glioblastoma 5 | 5,572
lung adenocarcinoma 5 | 2,713
lung cancer 5 | 4,466
Breast cancer 4 | 3,094
Gastrointestinal stromal tumor 4 | 61
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Pick disease 4 | 1,893
Pyruvate decarboxylase deficiency 4 | 15
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
malignant mesothelioma 4 | 3,162
primitive neuroectodermal tumor 4 | 3,031
ulcerative colitis 4 | 2,087
Carney Triad 3 | 3
Degenerative polyarthritis 3 | 93
Disease Progression 3 | 125
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Hemangioma 3 | 35
Mitochondrial complex II deficiency 3 | 5
Neurofibromatosis 3 | 37
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Stomach Neoplasms 3 | 282
Waldenstrons macroglobulinemia 3 | 765
atypical teratoid / rhabdoid tumor 3 | 4,369
extra-adrenal pheochromocytoma 3 | 7
invasive ductal carcinoma 3 | 2,950
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung cancer 3 | 2,798
pilocytic astrocytoma 3 | 3,086
COWDEN-LIKE SYNDROME (disorder) 2 | 2
Cancer 2 | 2,346
Chondroma 2 | 12
Cowden disease 2 | 16
Hereditary Paraganglioma-Pheochromocytoma Syndrome 2 | 3
Methylmalonic acidemia 2 | 39
Myocardial Ischemia 2 | 169
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Pheochromocytoma 2 | 22
Pyruvate Dehydrogenase Complex Deficiency Disease 2 | 2
Renal Cell Carcinoma 2 | 199
Sideroblastic anemia with spinocerebellar ataxia 2 | 6
Thyroid cancer 2 | 25
adrenocortical carcinoma 2 | 1,427
aldosterone-producing adenoma 2 | 664
atypical teratoid/rhabdoid tumor 2 | 1,095
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 2,514
hereditary spastic paraplegia 2 | 313
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
Burkitt Lymphoma 1 | 19
Cardiomyopathies 1 | 90
Cardiomyopathy 1 | 110
Carnitine palmitoyltransferase II deficiency 1 | 16
Cellulitis 1 | 13
Charcot-Marie-Tooth disease 1 | 74
Cholangitis 1 | 20
Cholera 1 | 33
Coffin-Lowry syndrome 1 | 10
Drug-Induced Liver Injury 1 | 118
Dystonia 1 | 77
Echinococcosis 1 | 28
Heart failure 1 | 80
Hypoglycemia 1 | 81
Kabuki syndrome 1 | 27
Leiomyoma 1 | 25
Leprosy 1 | 77
Liver Cirrhosis 1 | 101
Liver Cirrhosis, Experimental 1 | 108
MITOCHONDRIAL PYRUVATE CARRIER DEFICIENCY 1 | 1
Melanoma 1 | 261
Myeloma 1 | 3
Pharyngitis 1 | 17
Renal tubular acidosis 1 | 14
Respiratory failure 1 | 30
Spotted fever 1 | 7
Uterine fibroid 1 | 29
Vasomotor rhinitis 1 | 15
Von Hippel-Lindau disease 1 | 11

Tissue

Blood and immune system 21 | 17,995
Cardiovascular System 21 | 17,958
Digestive Tract 21 | 18,473
Endocrine System 21 | 18,512
Female tissues 21 | 18,647
Liver and Pancreas 21 | 18,136
Male tissues 21 | 17,969
Nervous System 21 | 18,561
Respiratory system 21 | 17,484
Skin and soft tissues 21 | 18,115
Urinary Tract 21 | 18,444

Target Family

Enzyme 20 | 4,146
Non-IDG 1 | 11,971

PathwayCommons: smpdb Pathway

Congenital lactic acidosis 21 | 21
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

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