Development Level

Tbio 14 | 10,625
Tchem 3 | 1,890

IMPC Term

abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
decreased circulating insulin ... 1 | 75
decreased heart rate 1 | 10
decreased mean platelet volume 1 | 12
decreased total body fat amoun... 1 | 186
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
persistence of hyaloid vascula... 1 | 22
shortened QRS complex duration 1 | 1

Disease

Cholestasis 7 | 93
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
psoriasis 7 | 6,685
lung cancer 6 | 4,466
pilocytic astrocytoma 6 | 3,086
malignant mesothelioma 5 | 3,162
ovarian cancer 5 | 8,484
Intrahepatic cholestasis 4 | 19
glioblastoma 4 | 5,572
osteosarcoma 4 | 7,933
pediatric high grade glioma 4 | 2,712
Atopic dermatitis 3 | 944
Cerebrotendinous xanthomatosis 3 | 12
Congenital bile acid synthesis defect 3 | 13
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 918
astrocytoma 3 | 1,493
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung carcinoma 3 | 2,844
medulloblastoma, large-cell 3 | 6,234
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
Adrenoleukodystrophy 2 | 31
Atherosclerosis 2 | 275
Breast cancer 2 | 3,094
Carcinoma 2 | 2,147
Chondrodysplasia punctata 2 | 41
Down syndrome 2 | 548
Fatty liver disease 2 | 84
Liver diseases 2 | 66
Multiple myeloma 2 | 1,327
Peroxisomal acyl-CoA oxidase deficiency 2 | 4
Prostatic Neoplasms 2 | 471
Refsum disease 2 | 21
Zellweger Syndrome 2 | 38
adrenocortical carcinoma 2 | 1,427
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
chronic rhinosinusitis 2 | 512
ependymoma 2 | 2,514
hereditary spastic paraplegia 2 | 313
interstitial cystitis 2 | 2,299
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,713
non-small cell lung cancer 2 | 2,798
oligodendroglioma 2 | 2,849
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 789
primitive neuroectodermal tumor 2 | 3,031
tuberculosis 2 | 1,557
Acquired immunodeficiency syndrome 1 | 164
Adenocarcinoma 1 | 115
Adenoma 1 | 165
Allergic hypersensitivity disease 1 | 123
Alzheimer's disease 1 | 644
Bipolar Disorder 1 | 266
Cancer 1 | 2,346
Cardiovascular system disease 1 | 194
Cataract 1 | 104
Cholera 1 | 33
Colorectal Neoplasms 1 | 217
Coronary artery disease 1 | 240
Coronary heart disease 1 | 59
Drug-Induced Liver Injury 1 | 118
Dystonia 1 | 77
Fatty Liver 1 | 48
Hypercholesterolemia 1 | 27
IGA Glomerulonephritis 1 | 454
Infantile refsum disease 1 | 19
Lassa fever 1 | 10
Leber congenital amaurosis 1 | 72
Leukoencephalopathies 1 | 7
Lipid metabolism disorder 1 | 102
Liver Cirrhosis 1 | 101
Liver Cirrhosis, Experimental 1 | 108
Liver disease 1 | 219
Major Depressive Disorder 1 | 106
Metabolic Bone Disorder 1 | 11
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 257
Paraplegia 1 | 71
Peripheral Neuropathy 1 | 303
Polycystic Ovary Syndrome 1 | 332
Polyneuropathy 1 | 30
Premature ovarian failure 1 | 64
Prostate cancer 1 | 172
Renal Cell Carcinoma 1 | 199
Schizoaffective disorder 1 | 33
Sensorineural hearing loss 1 | 107
West Syndrome 1 | 23
active ulcerative colitis 1 | 477
breast carcinoma 1 | 1,614
cystic fibrosis 1 | 1,665
non-inflammatory breast cancer 1 | 208
non-small cell lung carcinoma 1 | 413
progressive supranuclear palsy 1 | 674
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 17 | 17,995
Cardiovascular System 17 | 17,958
Digestive Tract 17 | 18,473
Endocrine System 17 | 18,512
Female tissues 17 | 18,647
Liver and Pancreas 17 | 18,136
Male tissues 17 | 17,969
Nervous System 17 | 18,561
Respiratory system 17 | 17,484
Skin and soft tissues 17 | 18,115
Urinary Tract 17 | 18,444

Target Family

Enzyme 14 | 4,146
Non-IDG 2 | 11,971
Transporter 1 | 473

PathwayCommons: smpdb Pathway

Cerebrotendinous Xanthomatosis... 17 | 17
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.79404 68.6 142
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.43962 31.1 33
Lysosomal acid lipase/cholesteryl ester hydrolase LIPA Tchem Enzyme -2.73800 567.4 132
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.59796 38.3 100
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.44034 296.1 443
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.19630 166.6 135
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.79562 66.0 151
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.65657 466.5 87