Development Level

Tchem 6 | 1,890
Tbio 3 | 10,625
Tclin 3 | 602

IMPC Phenotype

increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal lens morphology 1 | 73
abnormal motor coordination- b... 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 121
decreased circulating phosphat... 1 | 15
decreased exploration in new e... 1 | 9
decreased lean body mass 1 | 195
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased fasted circulating g... 1 | 68
increased total body fat amoun... 1 | 57
persistence of hyaloid vascula... 1 | 22
small kidney 1 | 10

Disease

Prostatic Neoplasms 9 | 471
psoriasis 8 | 6,685
Breast cancer 5 | 3,098
Prostate cancer 5 | 172
Endometriosis 4 | 535
Polycystic Ovary Syndrome 4 | 334
Pseudohermaphroditism 4 | 16
Alzheimer's disease 3 | 644
Amenorrhea 3 | 60
Congenital adrenal hyperplasia 3 | 74
Hyperandrogenism 3 | 32
Hypogonadism 3 | 70
Hypospadias 3 | 65
Infertility 3 | 163
Peripheral Neuropathy 3 | 303
Pick disease 3 | 1,893
adrenocortical carcinoma 3 | 1,427
lung cancer 3 | 4,473
Adenocarcinoma 2 | 115
Antley-Bixler syndrome 2 | 15
Cryptorchidism 2 | 67
Cushing's syndrome 2 | 47
Fatty Liver 2 | 48
Female infertility 2 | 28
Gynecomastia 2 | 13
Hypopituitarism 2 | 36
Intellectual disability 2 | 573
Liver Cirrhosis, Experimental 2 | 108
Male infertility 2 | 170
Mammary Neoplasms 2 | 410
Obesity 2 | 616
Parkinson's disease 2 | 364
Premature ovarian failure 2 | 64
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
cystic fibrosis 2 | 1,670
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
glioblastoma 2 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,714
malignant mesothelioma 2 | 3,163
medulloblastoma, large-cell 2 | 6,234
non-small cell lung cancer 2 | 2,798
oligodendroglioma 2 | 2,849
ovarian cancer 2 | 8,491
pancreatic cancer 2 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis 2 | 1,563
Acne vulgaris 1 | 16
Adrenal cortical adenoma 1 | 10
Adrenal rest tumor 1 | 5
Androgen insensitivity syndrome 1 | 11
Anovulation 1 | 20
Benign prostatic hyperplasia 1 | 7
Blastomycosis 1 | 12
Carcinoma of female breast 1 | 20
Carotid stenosis 1 | 5
Chandler syndrome 1 | 5
Coccidioidomycosis 1 | 7
Congenital bile acid synthesis defect 1 | 13
Congenital ichthyosiform erythroderma 1 | 27
Conn's syndrome 1 | 22
Diabetes Mellitus, Experimental 1 | 106
Disorders of Sex Development 1 | 5
Dystonia 1 | 77
Endometrial cancer 1 | 32
Esophageal Neoplasms 1 | 67
Fascioliasis 1 | 18
Fibrosis 1 | 40
Gestational Diabetes 1 | 17
Hemochromatosis 1 | 55
Histoplasmosis 1 | 22
Hormone receptor positive malignant neoplasm of breast 1 | 10
Hypokalemia 1 | 40
Ichthyosis vulgaris 1 | 15
Insulin Resistance 1 | 50
Intrahepatic cholestasis 1 | 19
Male pseudohermaphrodism with gynecomastia 1 | 1
Malignant tumor of prostate 1 | 26
Non-alcoholic Fatty Liver Disease 1 | 40
Ovarian Cysts 1 | 34
Ovarian dysfunction 1 | 19
Parkinson Disease 1 | 105
Pericarditis 1 | 14
Pityriasis versicolor 1 | 18
Prevention of Radiation-Induced Nausea and Vomiting 1 | 7
Primary pigmented nodular adrenocortical disease 1 | 13
Refractive error 1 | 43
Seborrheic dermatitis 1 | 19
Secondary malignant neoplasm of female breast 1 | 3
Systemic arterial pressure 1 | 56
Testicular Leydig cell tumor 1 | 2
Thiel-Behnke corneal dystrophy 1 | 6
Tinea cruris 1 | 12
Weight Gain 1 | 87
uncontrolled asthma 1 | 67

Tissue

Blood and immune system 12 | 17,994
Digestive Tract 12 | 18,472
Endocrine System 12 | 18,511
Female tissues 12 | 18,646
Liver and Pancreas 12 | 18,135
Skin and soft tissues 12 | 18,114
Urinary Tract 12 | 18,443
Cardiovascular System 11 | 17,957
Male tissues 11 | 17,968
Nervous System 11 | 18,560
Respiratory system 11 | 17,483

Target Family

Enzyme 12 | 4,146

PathwayCommons: smpdb Pathway

Aromatase deficiency 12 | 12
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aromatase CYP19A1 Tclin Enzyme -3.36046 2296.5 412
UDP-glucuronosyltransferase 2B11 UGT2B11 Tbio Enzyme -0.26858 1.75 45
Estrogen sulfotransferase SULT1E1 Tchem Enzyme -2.94205 866.8 134
UDP-glucuronosyltransferase 2B17 UGT2B17 Tbio Enzyme -1.88599 88.4 13
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.83291 68.6 142
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1 Tclin Enzyme -3.07458 1167.0 314
Sulfotransferase family cytosolic 2B member 1 SULT2B1 Tchem Enzyme -2.30274 169.2 163
3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 Tclin Enzyme -1.94833 82.0 120
Testosterone 17-beta-dehydrogenase 3 HSD17B3 Tchem Enzyme -1.98316 90.6 121
Steryl-sulfatase STS Tchem Enzyme -2.56574 353.7 188