Development Level

Tbio 12 | 10,625
Tchem 3 | 1,890

IMPC Term

enlarged heart atrium 1 | 2
preweaning lethality, complete... 1 | 633

Disease

osteosarcoma 9 | 7,933
ovarian cancer 9 | 8,484
psoriasis 8 | 6,685
Hereditary coproporphyria 7 | 9
Porphyria 7 | 9
lung cancer 7 | 4,466
Acute intermittent porphyria 6 | 14
Variegate Porphyria 6 | 9
malignant mesothelioma 6 | 3,162
Erythropoietic protoporphyria 5 | 15
Porphyria cutanea tarda 5 | 12
glioblastoma 4 | 5,572
group 3 medulloblastoma 4 | 2,254
medulloblastoma, large-cell 4 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Anemia 3 | 252
Cancer 3 | 2,346
Cutaneous porphyria 3 | 6
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,557
Bilirubin metabolic disorder 2 | 39
Fibrosis 2 | 40
Friedreich ataxia 2 | 23
Heart disease 2 | 279
Hepatoerythropoietic porphyria 2 | 5
Hypertensive disease 2 | 193
Hypertrichosis 2 | 23
Leigh disease 2 | 81
Liver disease 2 | 219
Liver diseases 2 | 66
Multiple myeloma 2 | 1,327
Myasthenic Syndrome due to Mutation in SCN4A 2 | 5
Neonatal jaundice 2 | 15
Pick disease 2 | 1,893
Toxic encephalopathy 2 | 131
Vascular disease 2 | 281
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
adrenocortical carcinoma 2 | 1,427
aldosterone-producing adenoma 2 | 664
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
atypical teratoid / rhabdoid tumor 2 | 4,369
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis 2 | 1,665
cytochrome-c oxidase deficiency disease 2 | 14
dermatomyositis 2 | 933
ependymoma 2 | 2,514
esophageal adenocarcinoma 2 | 737
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,713
lung carcinoma 2 | 2,844
non-small cell lung cancer 2 | 2,798
pediatric high grade glioma 2 | 2,712
ulcerative colitis 2 | 2,087
Age related macular degeneration 1 | 84
Angelman syndrome 1 | 38
Barrett's esophagus 1 | 183
Brain disease 1 | 83
Cardiomegaly 1 | 66
Carotid Artery Diseases 1 | 11
Cerebral Hemorrhage 1 | 27
Chronic Obstructive Airway Disease 1 | 47
Clubfoot 1 | 35
Diabetes Mellitus, Experimental 1 | 106
Fascioliasis 1 | 18
Growth Disorders 1 | 33
Head and Neck Neoplasms 1 | 23
Heart failure 1 | 80
Hepatitis 1 | 61
Hydrops Fetalis, Non-Immune 1 | 12
Hyperglycemia 1 | 120
Hyperinsulinism 1 | 63
Hypertrophic Cardiomyopathy 1 | 56
Hypospadias 1 | 65
Inverted follicular keratosis 1 | 3
Iron Metabolism Disorders 1 | 5
Ischemia 1 | 27
Kidney Failure, Chronic 1 | 45
Liver Cirrhosis, Experimental 1 | 108
Lung Injury 1 | 20
Mammary Neoplasms, Experimental 1 | 150
Meningioma 1 | 26
Neoplasm Invasiveness 1 | 127
Pantothenate kinase-associated neurodegeneration 1 | 15
Periodontal disease 1 | 37
Polyhydramnios 1 | 29
Prader-Willi syndrome 1 | 45
Pulmonary Fibrosis 1 | 66
Pulmonary emphysema 1 | 34
Renal Cell Carcinoma 1 | 199
Restless legs syndrome 1 | 28
Sideroblastic anemia 1 | 18
Silver-Russell syndrome 1 | 37
Spinal cord disease 1 | 22
Tyrosinemia 1 | 12
Ureteral disease 1 | 23
pre-eclampsia 1 | 67

Tissue

Blood and immune system 15 | 17,995
Digestive Tract 15 | 18,473
Endocrine System 15 | 18,512
Female tissues 15 | 18,647
Liver and Pancreas 15 | 18,136
Skin and soft tissues 15 | 18,115
Urinary Tract 15 | 18,444
Cardiovascular System 14 | 17,958
Male tissues 14 | 17,969
Nervous System 14 | 18,561
Respiratory system 13 | 17,484

Target Family

Enzyme 14 | 4,146
Non-IDG 1 | 11,971

PathwayCommons: smpdb Pathway

Acute Intermittent Porphyria 15 | 15
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.02257 108.1 75
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.45770 291.0 158
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.74695 57.8 136
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.28037 20.2 97
Protoheme IX farnesyltransferase, mitochondrial COX10 Tbio Enzyme -1.53844 36.7 127
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -2.97616 979.9 141
Heme oxygenase 1 HMOX1 Tbio Enzyme -3.69045 5707.9 664
Beta-glucuronidase GUSB Tchem Enzyme -3.10401 1119.9 240
UDP-glucuronosyltransferase 2B11 UGT2B11 Tbio Enzyme -0.24676 1.75 45
Porphobilinogen deaminase HMBS Tbio Enzyme -2.72357 543.7 180