Development Level

Tchem 14 | 1,890
Tbio 10 | 10,625
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased total body fat amoun... 2 | 57
decreased blood urea nitrogen ... 1 | 31
decreased circulating insulin ... 1 | 75
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
preweaning lethality, complete... 1 | 633

Disease

Cancer 18 | 2,346
ovarian cancer 14 | 8,484
Prostatic Neoplasms 12 | 471
psoriasis 12 | 6,685
osteosarcoma 11 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
glioblastoma 10 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
medulloblastoma, large-cell 10 | 6,234
lung cancer 9 | 4,466
Adverse reaction to drug 8 | 54
Breast cancer 8 | 3,094
active Crohn's disease 8 | 918
diabetes mellitus 8 | 1,663
Colorectal Neoplasms 7 | 217
atypical teratoid / rhabdoid tumor 7 | 4,369
malignant mesothelioma 7 | 3,162
non-small cell lung cancer 7 | 2,798
pediatric high grade glioma 7 | 2,712
pilocytic astrocytoma 7 | 3,086
tuberculosis 7 | 1,557
Drug-Induced Liver Injury 6 | 118
Liver disease 6 | 219
Mammary Neoplasms 6 | 410
Peripheral Neuropathy 6 | 303
Rheumatoid Arthritis 6 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
Liver carcinoma 5 | 217
Lung Neoplasms 5 | 171
Multiple myeloma 5 | 1,327
lung adenocarcinoma 5 | 2,713
lung carcinoma 5 | 2,844
ulcerative colitis 5 | 2,087
Acute kidney injury 4 | 65
Bilirubin metabolic disorder 4 | 39
Carcinoma 4 | 2,147
Disease Progression 4 | 125
Liver Cirrhosis, Experimental 4 | 108
Neutropenia 4 | 78
Parkinson Disease 4 | 102
Schizophrenia 4 | 501
astrocytoma 4 | 1,493
cutaneous lupus erythematosus 4 | 1,056
ependymoma 4 | 2,514
interstitial cystitis 4 | 2,299
non primary Sjogren syndrome sicca 4 | 840
primitive neuroectodermal tumor 4 | 3,031
sonic hedgehog group medulloblastoma 4 | 1,482
Amphetamine-Related Disorders 3 | 74
Cholestasis 3 | 93
Chromosome Aberrations 3 | 15
Contact Dermatitis 3 | 80
Diarrhea 3 | 155
Endometriosis 3 | 535
Hepatitis C 3 | 90
Kernicterus 3 | 12
Liver Neoplasms, Experimental 3 | 48
Neoplasm Metastasis 3 | 138
Obesity 3 | 616
Squamous cell carcinoma of esophagus 3 | 82
Squamous cell carcinoma of the head and neck 3 | 24
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
gastric carcinoma 3 | 832
group 3 medulloblastoma 3 | 2,254
invasive ductal carcinoma 3 | 2,950
non-small cell lung carcinoma 3 | 413
pancreatic cancer 3 | 2,300
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
Adenoma 2 | 165
Alzheimer's disease 2 | 644
Anemia 2 | 252
Atrial Fibrillation 2 | 110
Attention deficit hyperactivity disorder 2 | 156
Coronary artery disease 2 | 240
Dementia 2 | 129
Epilepsy 2 | 346
Hypertensive disease 2 | 193
Kidney Neoplasm 2 | 27
Kidney disease 2 | 396
Liver diseases 2 | 66
Myocardial Ischemia 2 | 169
Necrosis 2 | 51
Pain agnosia 2 | 99
Parkinson's disease 2 | 364
Pick disease 2 | 1,893
Renal Cell Carcinoma 2 | 199
Stomach Neoplasms 2 | 282
Substance-Related Disorders 2 | 114
Thalassemia 2 | 46
Toxic encephalopathy 2 | 131
active ulcerative colitis 2 | 477
adrenocortical adenoma 2 | 134
cystic fibrosis 2 | 1,665
dermatomyositis 2 | 933
juvenile dermatomyositis 2 | 1,189
nervous system disorder 2 | 53

Tissue

Digestive Tract 27 | 18,473
Liver and Pancreas 27 | 18,136
Urinary Tract 27 | 18,444
Blood and immune system 26 | 17,995
Female tissues 26 | 18,647
Male tissues 26 | 17,969
Cardiovascular System 25 | 17,958
Endocrine System 25 | 18,512
Nervous System 25 | 18,561
Respiratory system 25 | 17,484
Skin and soft tissues 25 | 18,115

Target Family

Enzyme 15 | 4,146
Non-IDG 7 | 11,971
Transporter 5 | 473

PathwayCommons: smpdb Pathway

Acetaminophen Metabolism Pathw... 27 | 27
Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.28487 2003.3 918
Protein disulfide-isomerase A4 PDIA4 Tbio Enzyme -1.63645 41.6 248
Multidrug resistance-associated protein 4 ABCC4 Tbio Transporter -2.50986 316.0 288
Multidrug resistance-associated protein 5 ABCC5 Tchem Transporter -2.06962 117.0 229
Peptidyl-prolyl cis-trans isomerase B PPIB Tchem Enzyme -2.21802 177.2 242
Estrogen sulfotransferase SULT1E1 Tchem Enzyme -2.91745 866.8 134
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.76635 60.2 66
Sulfotransferase 1A1 SULT1A1 Tchem Enzyme -2.49044 330.9 248
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.35754 2531.5 239
Stromal cell-derived factor 2-like protein 1 SDF2L1 Tdark Non-IDG -0.60865 4.07 54