Development Level

Tbio 827 | 10,625
Tchem 340 | 1,890
Tclin 149 | 602
Tdark 101 | 7,003

Collection

Eligible Kinase Proteins 11 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 83 | 633
embryonic lethality prior to o... 30 | 148
embryonic lethality prior to t... 28 | 187
abnormal behavior 26 | 226
preweaning lethality, incomple... 22 | 260
decreased total body fat amoun... 20 | 186
decreased body weight 18 | 174
decreased bone mineral content 17 | 157
abnormal lens morphology 16 | 73
decreased bone mineral density 15 | 126
decreased lean body mass 15 | 195
hypoactivity 14 | 89
increased circulating alkaline... 14 | 119
increased grip strength 14 | 83
abnormal bone structure 11 | 131
abnormal embryo size 11 | 112
abnormal retina morphology 11 | 100
decreased circulating HDL chol... 11 | 77
decreased circulating triglyce... 11 | 83
increased lean body mass 10 | 107
decreased circulating glucose ... 9 | 121
increased circulating potassiu... 9 | 31
increased circulating sodium l... 9 | 71
abnormal seminal vesicle morph... 8 | 47
decreased circulating choleste... 8 | 85
decreased erythrocyte cell num... 8 | 43
decreased grip strength 8 | 123
decreased mean corpuscular vol... 8 | 50
enlarged heart 8 | 111
increased fasted circulating g... 8 | 68
increased mean corpuscular hem... 8 | 93
prenatal lethality prior to he... 8 | 64
abnormal bone mineralization 7 | 55
decreased body length 7 | 108
decreased circulating serum al... 7 | 79
decreased hemoglobin content 7 | 53
decreased leukocyte cell numbe... 7 | 54
decreased mean platelet volume 7 | 12
impaired glucose tolerance 7 | 52
improved glucose tolerance 7 | 56
increased body weight 7 | 42
short tibia 7 | 82
thrombocytopenia 7 | 46
abnormal retinal pigmentation 6 | 61
decreased circulating alanine ... 6 | 53
decreased circulating alkaline... 6 | 41
decreased circulating insulin ... 6 | 75
decreased startle reflex 6 | 48
hyperactivity 6 | 108
increased blood urea nitrogen ... 6 | 44
increased bone mineral content 6 | 92
increased mean corpuscular vol... 6 | 91
abnormal epididymis morphology 5 | 31
cardiovascular system phenotyp... 5 | 35
decreased caudal vertebrae num... 5 | 49
decreased circulating calcium ... 5 | 33
decreased circulating chloride... 5 | 32
decreased circulating glycerol... 5 | 19
female infertility 5 | 34
increased T cell number 5 | 15
increased total body fat amoun... 5 | 57
abnormal behavioral response t... 4 | 52
abnormal kidney morphology 4 | 30
abnormal neural tube closure 4 | 37
abnormal retinal vasculature m... 4 | 15
decreased circulating LDL chol... 4 | 37
decreased circulating creatini... 4 | 31
decreased circulating total pr... 4 | 41
decreased eosinophil cell numb... 4 | 41
decreased heart weight 4 | 44
decreased prepulse inhibition 4 | 52
embryonic growth retardation 4 | 28
enlarged epididymis 4 | 27
increased B cell number 4 | 23
increased circulating calcium ... 4 | 32
increased circulating chloride... 4 | 43
increased exploration in new e... 4 | 56
increased startle reflex 4 | 38
persistence of hyaloid vascula... 4 | 22
abnormal coat appearance 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal cranium morphology 3 | 32
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
abnormal skin coloration 3 | 18
abnormal tooth morphology 3 | 24
decreased T cell number 3 | 31
decreased effector memory CD8-... 3 | 24
decreased fasted circulating g... 3 | 49
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased neutrophil cell numb... 3 | 37
increased CD4-positive, CD25-p... 3 | 18
increased bone mineral density 3 | 52
increased circulating bilirubi... 3 | 16
increased circulating choleste... 3 | 53
increased circulating serum al... 3 | 25
increased heart weight 3 | 37
increased or absent threshold ... 3 | 128
increased rib number 3 | 41

Disease

ovarian cancer 716 | 8,484
osteosarcoma 590 | 7,933
psoriasis 585 | 6,685
medulloblastoma, large-cell 480 | 6,234
lung cancer 435 | 4,466
glioblastoma 434 | 5,572
atypical teratoid / rhabdoid tumor 340 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 315 | 3,289
pancreatic ductal adenocarcinoma liver metastasis 310 | 1,795
malignant mesothelioma 299 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 279 | 2,956
Breast cancer 271 | 3,094
invasive ductal carcinoma 263 | 2,950
non-small cell lung cancer 258 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 256 | 2,988
lung carcinoma 252 | 2,844
ulcerative colitis 240 | 2,087
pilocytic astrocytoma 239 | 3,086
lung adenocarcinoma 237 | 2,713
primitive neuroectodermal tumor 231 | 3,031
oligodendroglioma 221 | 2,849
pancreatic cancer 219 | 2,300
interstitial cystitis 215 | 2,299
pediatric high grade glioma 212 | 2,712
ependymoma 199 | 2,514
Cancer 193 | 2,346
astrocytic glioma 191 | 2,241
subependymal giant cell astrocytoma 184 | 2,287
Multiple myeloma 183 | 1,327
ductal carcinoma in situ 173 | 1,745
pituitary cancer 172 | 1,972
tuberculosis 171 | 1,557
adult high grade glioma 158 | 2,148
group 4 medulloblastoma 157 | 1,875
colon cancer 151 | 1,475
cystic fibrosis 149 | 1,665
group 3 medulloblastoma 148 | 2,254
Pick disease 146 | 1,893
astrocytoma 144 | 1,493
adrenocortical carcinoma 139 | 1,427
diabetes mellitus 138 | 1,663
breast carcinoma 126 | 1,614
medulloblastoma 125 | 1,524
active Crohn's disease 124 | 918
posterior fossa group A ependymoma 121 | 1,511
posterior fossa group B ependymoma 117 | 1,530
primary pancreatic ductal adenocarcinoma 109 | 1,271
Carcinoma 106 | 2,147
Waldenstrons macroglobulinemia 102 | 765
atypical teratoid/rhabdoid tumor 99 | 1,095
Obesity 98 | 616
sonic hedgehog group medulloblastoma 97 | 1,482
cutaneous lupus erythematosus 94 | 1,056
gastric carcinoma 93 | 832
Atopic dermatitis 90 | 944
acute quadriplegic myopathy 89 | 1,157
nasopharyngeal carcinoma 87 | 1,056
Rheumatoid Arthritis 82 | 1,160
non primary Sjogren syndrome sicca 80 | 840
Prostatic Neoplasms 75 | 471
esophageal adenocarcinoma 75 | 737
juvenile dermatomyositis 73 | 1,189
dermatomyositis 72 | 933
spina bifida 71 | 1,064
aldosterone-producing adenoma 69 | 664
nephrosclerosis 68 | 329
Intellectual disability 67 | 573
Schizophrenia 67 | 501
primary Sjogren syndrome 66 | 789
active ulcerative colitis 63 | 477
acute myeloid leukemia 62 | 780
fibroadenoma 60 | 557
Alzheimer's disease 59 | 644
Epilepsy 55 | 346
Endometriosis 51 | 535
pancreatic carcinoma 50 | 567
Down syndrome 49 | 548
Diabetes mellitus type 2 48 | 69
Liver carcinoma 47 | 217
Parkinson's disease 47 | 364
hepatocellular carcinoma 47 | 532
chronic rhinosinusitis 46 | 512
IGA Glomerulonephritis 45 | 454
Mammary Neoplasms 45 | 410
tuberculosis and treatment for 6 months 45 | 686
Hypertension 43 | 287
Neurodegenerative disease 42 | 383
progressive supranuclear palsy 42 | 674
Duchenne muscular dystrophy 41 | 602
Peripheral Neuropathy 41 | 303
Atherosclerosis 40 | 275
Kidney disease 40 | 396
Autistic Disorder 39 | 320
Treatment Refractory Type 2 Diabetes Mellitus 39 | 53
mucosa-associated lymphoid tissue lymphoma 39 | 480
Anemia 38 | 252
non-small cell lung carcinoma 38 | 413
Colorectal Neoplasms 37 | 217
Polycystic Ovary Syndrome 37 | 332
Stomach Neoplasms 36 | 282

Tissue

Digestive Tract 1,411 | 18,473
Female tissues 1,410 | 18,647
Nervous System 1,409 | 18,561
Urinary Tract 1,408 | 18,444
Endocrine System 1,407 | 18,512
Liver and Pancreas 1,406 | 18,136
Skin and soft tissues 1,403 | 18,115
Blood and immune system 1,399 | 17,995
Cardiovascular System 1,393 | 17,958
Male tissues 1,391 | 17,969
Respiratory system 1,371 | 17,484

Target Family

Enzyme 1,017 | 4,146
Transporter 196 | 473
Non-IDG 107 | 11,971
Kinase 84 | 634
Epigenetic 9 | 242
TF/Epigenetic 2 | 38
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

PathwayCommons: recon Pathway

Thiele2013 - Human metabolism ... 1,417 | 1,417

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.52686 33.5 80
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A MGAT5 Tchem Enzyme -2.07315 133.7 104