Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating creatine... 1 | 5
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24

Disease

Carcinoma 12 | 11,493
Cancer 10 | 2,499
lung cancer 9 | 4,740
ovarian cancer 9 | 8,520
psoriasis 9 | 6,694
osteosarcoma 8 | 7,950
Kidney cancer 6 | 2,613
glioblastoma 6 | 5,792
medulloblastoma, large-cell 6 | 6,241
astrocytoma 5 | 1,146
atypical teratoid / rhabdoid tumor 5 | 5,112
Breast Neoplasms 4 | 445
Cryptorchidism 4 | 296
Mammary Neoplasms 4 | 425
Multiple myeloma 4 | 1,332
Prostatic Neoplasms 4 | 495
acute quadriplegic myopathy 4 | 1,158
dermatomyositis 4 | 966
group 3 medulloblastoma 4 | 4,104
spina bifida 4 | 1,074
Abnormality of cardiovascular system morphology 3 | 23
Acquired scoliosis 3 | 281
Aplasia/Hypoplasia of the distal phalanx of the 5th finger 3 | 5
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Broad flat nasal bridge 3 | 236
Bushy eyebrows 3 | 49
Cerebellar hypoplasia and atrophy 3 | 41
Coarse facial features 3 | 108
Coffin-Siris syndrome 3 | 17
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Congenital deafness 3 | 185
Curvature of spine 3 | 282
Dandy-Walker Syndrome 3 | 39
Deafness 3 | 198
Dental abnormalities 3 | 60
Depressed nasal bridge 3 | 195
Depressed nasal ridge 3 | 51
Depressed nasal root/bridge 3 | 195
Dull intelligence 3 | 645
Epilepsy 3 | 792
Feeding difficulties in infancy 3 | 175
Fetal Growth Retardation 3 | 189
Full lower lip 3 | 64
Generalized hirsutism 3 | 36
Global developmental delay 3 | 608
Hearing Loss, Partial 3 | 185
Hypoplastic fifth fingernail 3 | 5
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Joint hyperflexibility 3 | 78
Long eyelashes 3 | 37
Low intelligence 3 | 645
Macrostomia 3 | 72
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Nasal bridge wide 3 | 236
Nystagmus 3 | 317
Patella aplasia-hypoplasia 3 | 12
Poor school performance 3 | 645
Prominent lower lip 3 | 64
Recurrent respiratory infections 3 | 141
Seizures 3 | 596
Short distal phalanges 3 | 50
Short stature 3 | 531
Slow-growing hair 3 | 19
Small head 3 | 374
Strabismus 3 | 270
Thickened facial skin with coarse facial features 3 | 108
Tooth Abnormalities 3 | 69
aldosterone-producing adenoma 3 | 665
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
hearing impairment 3 | 199
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
medulloblastoma 3 | 720
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Astrocytoma, Pilocytic 2 | 3,081
Crohn's disease 2 | 321
Duchenne muscular dystrophy 2 | 601
Endometriosis 2 | 540
Male infertility 2 | 206
Polycystic ovary syndrome 2 | 360
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
colon cancer 2 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Skin and soft tissues 15 | 17,230
Cardiovascular System 14 | 15,192
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Urinary Tract 14 | 16,678

Target Family

Non-IDG 6 | 12,091
Epigenetic 3 | 242
Nuclear Receptor 3 | 48
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

PathwayCommons: pid Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear receptor subfamily 0 group B member 1 NR0B1 Tbio Nuclear Receptor -2.73235 544.8 477
Zinc finger protein 14 ZNF14 Tdark Transcription Factor -0.18877 1.41 41
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 SMARCB1 Tbio Non-IDG -2.77635 619.8 379
Complement C3 C3 Tbio Non-IDG -3.55963 3446.1 1079
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
NEDD8-conjugating enzyme Ubc12 UBE2M Tbio Non-IDG -1.32249 16.4 115
Transcription activator BRG1 SMARCA4 Tchem Epigenetic -2.86389 713.1 332
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 SMARCE1 Tbio Transcription Factor -1.51153 35.7 270
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.36613 239.2 307