Development Level

Tbio 21 | 11,445
Tchem 11 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

thrombocytopenia 3 | 56
decreased total body fat amoun... 2 | 207
increased mean corpuscular hem... 2 | 96
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
decreased circulating alanine ... 1 | 47
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 23 | 11,493
ovarian cancer 21 | 8,520
osteosarcoma 20 | 7,950
Cancer 19 | 2,499
lung carcinoma 19 | 2,843
glioblastoma 18 | 5,792
medulloblastoma, large-cell 16 | 6,241
psoriasis 16 | 6,694
lung cancer 15 | 4,740
Astrocytoma, Pilocytic 13 | 3,081
atypical teratoid / rhabdoid tumor 13 | 5,112
non-small cell lung cancer 12 | 2,890
Kidney cancer 11 | 2,613
adult high grade glioma 11 | 3,801
interstitial cystitis 11 | 2,312
ulcerative colitis 11 | 1,819
Breast cancer 10 | 3,578
ependymoma 10 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
primitive neuroectodermal tumor 10 | 3,035
subependymal giant cell astrocytoma 10 | 2,287
group 3 medulloblastoma 9 | 4,104
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
Liver Cirrhosis, Experimental 8 | 769
Pick disease 8 | 1,894
lung adenocarcinoma 8 | 2,716
tuberculosis 8 | 2,010
active ulcerative colitis 7 | 764
malignant mesothelioma 7 | 3,232
primary Sjogren syndrome 7 | 735
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
diabetes mellitus 6 | 1,728
Bipolar Disorder 5 | 666
Cardiomegaly 5 | 116
Depressive disorder 5 | 409
Intellectual disability 5 | 1,016
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
periodontitis 5 | 293
Asthma 4 | 385
Breast Neoplasms 4 | 445
Epilepsy 4 | 792
Heart disease 4 | 306
Kidney disease 4 | 430
Mammary Neoplasms 4 | 425
Melanoma 4 | 711
Multiple myeloma 4 | 1,332
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
esophageal adenocarcinoma 4 | 737
mucosa-associated lymphoid tissue lymphoma 4 | 484
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Anemia 3 | 365
Arthritis 3 | 290
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Coronary artery disease 3 | 268
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Hypertension 3 | 396
Inflammatory bowel disease 3 | 151
Liver cancer 3 | 604
Low intelligence 3 | 645
Lung disease 3 | 142
Major Depressive Disorder 3 | 301
Mental Depression 3 | 333
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Myocardial Ischemia 3 | 169
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Orbital separation excessive 3 | 244
Pectus excavatum 3 | 100
Poor school performance 3 | 645
Seizures 3 | 596
Skin cancer 3 | 469
Unipolar Depression 3 | 250
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
group 4 medulloblastoma 3 | 1,855
head and neck cancer 3 | 271
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
sarcoidosis 3 | 370

Tissue

Blood and immune system 35 | 16,909
Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Skin and soft tissues 35 | 17,230
Cardiovascular System 34 | 15,192
Respiratory system 34 | 16,393
Urinary Tract 34 | 16,678

Target Family

Enzyme 13 | 4,145
Non-IDG 12 | 12,091
Kinase 9 | 634
GPCR 1 | 408

PathwayCommons: pid Pathway

http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 137 | 137
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.89 89
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Protein kinase C gamma type PRKCG Tchem Kinase -2.04120 103.9 435
Dedicator of cytokinesis protein 2 DOCK2 Tbio Non-IDG -1.66165 51.5 140
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464